公开(公告)号：US20110306513A1

公开(公告)日：2011-12-15

申请号：US13139095

申请日：2009-12-03

申请人： Eun Young Song ,  Hee Gu Lee ,  Young II Yeom ,  Na Young Ji ,  Jung II Lee ,  Min A. Kang ,  Young Joo Kim ,  Yoon Hee Kang ,  Jae Wha Kim

发明人： Eun Young Song ,  Hee Gu Lee ,  Young II Yeom ,  Na Young Ji ,  Jung II Lee ,  Min A. Kang ,  Young Joo Kim ,  Yoon Hee Kang ,  Jae Wha Kim

IPC分类号： C40B30/04 ,  C40B40/10 ,  C12Q1/68 ,  C07K16/40 ,  G01N33/577 ,  C07H21/00 ,  C07K16/18 ,  C07K16/24 ,  C40B40/06 ,  G01N33/574

CPC分类号： G01N33/5023 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/57438

摘要： The present invention relates to the elucidation of a gene that can act as a novel marker for liver cancer diagnosis and to diagnostic and prognostic measurements of liver cancer using the same. More specifically, it relates to a diagnosis kit that enables diagnostic and prognostic measurement of a liver cancer using a preparation that measures expression levels of at least one gene selected from a group of liver cancer diagnosis markers consisting of S100P, NK4, CCL20, CSPG2, PLAU, MMP12, ESM-1, ABHD7, HCAPG, CXCL-3, Col5A2, MAGEA, GSN, CDC2, CST1, MELK, ATAD2, FAP and MSN and/or a method for diagnostic and prognostic measurement of liver cancer using the same. These have been discovered using normal liver tissues and liver cancer tissues collected from the same liver cancer patient of the present invention and represent the markers whose accuracy and reliability have been greatly improved as markers of liver cancer. The markers of the present invention can be used for the accurate diagnosis and prognosis of liver cancer.

摘要翻译： 本发明涉及可以作为肝癌诊断的新型标志物的基因的阐明，以及使用该基因的肝癌的诊断和预后测定。 更具体地说，本发明涉及能够使用测定从S100P，NK4，CCL20，CSPG2等组成的肝癌诊断标志物组中选出的至少一种基因的表达量的制剂的肝癌的诊断和预后测定的诊断试剂盒， PLAU，MMP12，ESM-1，ABHD7，HCAPG，CXCL-3，Col5A2，MAGEA，GSN，CDC2，CST1，MELK，ATAD2，FAP和MSN和/或使用其进行肝癌的诊断和预后测量的方法。 使用从本发明的同一肝癌患者收集的正常肝组织和肝癌组织已经发现了这些，并且其标志物的准确性和可靠性已经作为肝癌的标志物而大大改善。 本发明的标记物可用于肝癌的准确诊断和预后。

公开(公告)号：US20110201512A1

公开(公告)日：2011-08-18

申请号：US12822556

申请日：2010-06-24

申请人： Hee Gu Lee ,  Eun Young Song ,  Young II Yeom ,  Jae Wha Kim ,  Jong Tae Kim ,  Kyung Sook Chung ,  Mi Sun Won ,  Hyun Hyo Suh ,  Joo Woong Park ,  Min Ah Kang

发明人： Hee Gu Lee ,  Eun Young Song ,  Young II Yeom ,  Jae Wha Kim ,  Jong Tae Kim ,  Kyung Sook Chung ,  Mi Sun Won ,  Hyun Hyo Suh ,  Joo Woong Park ,  Min Ah Kang

IPC分类号： C40B30/04 ,  C12Q1/68 ,  G01N33/574

CPC分类号： G01N33/57419 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

摘要： The present invention relates to a method for detecting a colon cancer in a human, comprising the steps of: (a) providing a biological sample from the human; and (b) detecting the level of a ATAD2 nucleic acid or a ATAD2 protein in the biological sample, relative to the level of the ATAD2 nucleic acid or the ATAD2 protein in a control sample from a normal human, wherein an increased level of the ATAD2 nucleic acid or the ATAD2 protein in the biological sample compared to the control sample indicates that the human has the colon cancer. The biomarker of this invention was identified using normal colon tissue, colon cancer tissue and metastatic cancer tissue derived from a colon cancer patient. Therefore, the accuracy and reliability of the present biomarker for colon cancer and/or metastasis are much more significantly improved. In addition, the biomarker of this invention permits to identify and predict colon cancer or metastasis in an accurate manner.

摘要翻译： 本发明涉及一种检测人类结肠癌的方法，包括以下步骤：（a）从人体提供生物样品; 相对于来自正常人的对照样品中的ATAD2核酸或ATAD2蛋白的水平，检测生物样品中ATAD2核酸或ATAD2蛋白的水平，其中ATAD2的升高水平 与对照样品相比，生物样品中的核酸或ATAD2蛋白表明人类具有结肠癌。 使用来自结肠癌患者的正常结肠组织，结肠癌组织和转移性癌组织鉴定本发明的生物标志物。 因此，目前用于结肠癌和/或转移的生物标志物的准确性和可靠性大大提高。 此外，本发明的生物标志物允许以准确的方式鉴定和预测结肠癌或转移。

公开(公告)号：US20110251097A1

公开(公告)日：2011-10-13

申请号：US13126500

申请日：2009-04-20

申请人： Eun Young Song ,  Hee Gu Lee ,  Young Il Yeom ,  Jae Wha Kim ,  Na Young Ji ,  Kyung-Sook Chung ,  Misun Won ,  Seon-Young Kim ,  Joo Heon Kim ,  Young Ho Kim ,  Ho Kyung Chun

发明人： Eun Young Song ,  Hee Gu Lee ,  Young Il Yeom ,  Jae Wha Kim ,  Na Young Ji ,  Kyung-Sook Chung ,  Misun Won ,  Seon-Young Kim ,  Joo Heon Kim ,  Young Ho Kim ,  Ho Kyung Chun

IPC分类号： C40B30/04 ,  G01N33/53 ,  G01N33/566 ,  C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/158

摘要： The present invention relates to a composition for diagnosing colon cancer. The composition comprises at least one marker for measuring an mRNA or protein expression level of at least one gene specific for colon cancer. It can screen the genes which are overexpressed specifically only in colon cancer tissues or blood. The present invention can quantitatively analyze both the mRNA expression levels of the genes and the expression levels of the proteins encoded by the gene at the same time, thereby diagnosing colon caner of an early stage with a high level of reliability.

摘要翻译： 本发明涉及用于诊断结肠癌的组合物。 组合物包含至少一种用于测量至少一种对结肠癌特异性基因的mRNA或蛋白质表达水平的标记物。 它可以筛选出仅在结肠癌组织或血液中过度表达的基因。 本发明可以同时定量分析基因的mRNA表达水平和基因编码的蛋白质的表达水平，从而以高可靠性诊断早期的结肠癌。

公开(公告)号：US20100248244A1

公开(公告)日：2010-09-30

申请号：US12744223

申请日：2007-11-23

申请人： Eun Young Song ,  Mi Young Park ,  Hyang Sin Lee ,  Hee Gu Lee ,  Jae Wha Kim ,  In Seong Choe ,  Min A. Kang ,  Mi Sun Won ,  Kyung Sook Chung ,  Young Ho Kim ,  Ho Kyung Chun ,  Young Il Yeom ,  Seon-Young Kim

发明人： Eun Young Song ,  Mi Young Park ,  Hyang Sin Lee ,  Hee Gu Lee ,  Jae Wha Kim ,  In Seong Choe ,  Min A. Kang ,  Mi Sun Won ,  Kyung Sook Chung ,  Young Ho Kim ,  Ho Kyung Chun ,  Young Il Yeom ,  Seon-Young Kim

IPC分类号： C12Q1/68 ,  C07H21/00 ,  C07K16/18 ,  G01N33/48 ,  G01N33/53 ,  C07H21/02

CPC分类号： C12Q1/6886 ,  C12Q2600/158

摘要： Disclosed herein is a colorectal cancer marker for diagnosing colorectal cancer based on ESM-I overexpression in tissues, cells or body fluids of colorectal cancer patients. Disclosed also is the use of the colorectal cancer marker in the development of therapeutic agents for cancer and in the diagnosis and treatment of colorectal cancer.

摘要翻译： 本文公开了一种基于ESM-1在结肠直肠癌患者的组织，细胞或体液中过度表达的用于诊断结肠直肠癌的结肠直肠癌标志物。 还公开了结肠直肠癌标志物在癌症治疗剂的开发和结肠直肠癌的诊断和治疗中的应用。

公开(公告)号：US08283129B2

公开(公告)日：2012-10-09

申请号：US12744223

申请日：2007-11-23

申请人： Eun Young Song ,  Mi Young Park ,  Hyang Sin Lee ,  Hee Gu Lee ,  Jae Wha Kim ,  In Seong Choe ,  Min A Kang ,  Mi Sun Won ,  Kyung-Sook Chung ,  Young Ho Kim ,  Ho Kyung Chun ,  Young Il Yeom ,  Seon-Young Kim

发明人： Eun Young Song ,  Mi Young Park ,  Hyang Sin Lee ,  Hee Gu Lee ,  Jae Wha Kim ,  In Seong Choe ,  Min A Kang ,  Mi Sun Won ,  Kyung-Sook Chung ,  Young Ho Kim ,  Ho Kyung Chun ,  Young Il Yeom ,  Seon-Young Kim

IPC分类号： G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/158

摘要： Disclosed herein is a colorectal cancer marker for diagnosing colorectal cancer based on ESM-I overexpression in tissues, cells or body fluids of colorectal cancer patients. Disclosed also is the use of the colorectal cancer marker in the development of therapeutic agents for cancer and in the diagnosis and treatment of colorectal cancer.

摘要翻译： 本文公开了一种基于ESM-1在结肠直肠癌患者的组织，细胞或体液中过度表达的用于诊断结肠直肠癌的结肠直肠癌标志物。 还公开了结肠直肠癌标志物在癌症治疗剂的开发和结肠直肠癌的诊断和治疗中的应用。

公开(公告)号：US20090130694A1

公开(公告)日：2009-05-21

申请号：US12087224

申请日：2006-09-25

申请人： Hee Gu Lee ,  Yuk Pheel Park ,  Jae Wha Kim ,  Eun Young Song ,  Do Young Yoon ,  Young Il Yeom ,  Seung-Chul Choi

发明人： Hee Gu Lee ,  Yuk Pheel Park ,  Jae Wha Kim ,  Eun Young Song ,  Do Young Yoon ,  Young Il Yeom ,  Seung-Chul Choi

IPC分类号： G01N33/574

CPC分类号： G01N33/57446

摘要： Disclosed is a diagnostic kit for gastric cancer. It comprises an agent capable of detecting and quantitatively assaying the gastric cancer marker Mac-2BP (Mac-2 binding protein). Also, a method for detecting the gastric cancer marker using the kit is disclosed.

摘要翻译： 公开了一种胃癌诊断试剂盒。 它包括能够检测和定量测定胃癌标记物Mac-2BP（Mac-2结合蛋白）的试剂。 另外，公开了使用该试剂盒检测胃癌标记物的方法。

公开(公告)号：US09075066B2

公开(公告)日：2015-07-07

申请号：US12679879

申请日：2009-04-21

申请人： Hee Gu Lee ,  Eun Young Song ,  Min Ah Kang ,  Jong Tae Kim ,  Jae Wha Kim ,  Young Il Yeom ,  Seon Young Kim ,  Kyung Chan Park

发明人： Hee Gu Lee ,  Eun Young Song ,  Min Ah Kang ,  Jong Tae Kim ,  Jae Wha Kim ,  Young Il Yeom ,  Seon Young Kim ,  Kyung Chan Park

IPC分类号： G01N33/53 ,  G01N33/574 ,  C12Q1/68

CPC分类号： G01N33/57446 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2500/04

摘要： The present invention relates to a biomarker for gastric cancer, CST1 (cysteine proteinase inhibitor, type 2 family), DCC1 (Defective in sister chromatid cohesion homolog 1), IFITM1 (interferon induced transmembrane protein 1) or MELK (maternal embryonic leucine zipper kinase). More particularly, the present invention relates to a diagnostic composition for gastric cancer comprising an agent measuring the expression level of CST1, DCC1, IFITM1 or MELK, a kit comprising the composition, a method for detecting the marker, and a method for screening a therapeutic agent for gastric cancer using the marker.

摘要翻译： 本发明涉及胃癌生物标志物，CST1（半胱氨酸蛋白酶抑制剂，2型家族），DCC1（姐妹染色单体内聚同系物1缺陷），IFITM1（干扰素诱导的跨膜蛋白1）或MELK（母体白蛋白亮氨酸拉链激酶） 。 更具体地，本发明涉及用于胃癌的诊断组合物，其包含测量CST1，DCC1，IFITM1或MELK的表达水平的试剂，包含该组合物的试剂盒，用于检测标记物的方法和用于筛选治疗 使用标记的胃癌药物。

公开(公告)号：US20110152106A1

公开(公告)日：2011-06-23

申请号：US12679879

申请日：2009-04-21

申请人： Hee Gu Lee ,  Eun Young Song ,  Min Ah Kang ,  Jong Tae Kim ,  Eun Hwa Choi ,  Hyo Ran Yoon ,  Jae Wha Kim

发明人： Hee Gu Lee ,  Eun Young Song ,  Min Ah Kang ,  Jong Tae Kim ,  Eun Hwa Choi ,  Hyo Ran Yoon ,  Jae Wha Kim

IPC分类号： C40B30/00 ,  C07H21/00 ,  C07K16/00 ,  C12Q1/68 ,  C40B40/06 ,  C40B40/10 ,  G01N33/53

CPC分类号： G01N33/57446 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2500/04

摘要： The present invention relates to a biomarker for gastric cancer, CST1 (cysteine proteinase inhibitor, type 2 family), DCC1 (Defective in sister chromatid cohesion homolog 1), IFITM1 (interferon induced transmembrane protein 1) or MELK (maternal embryonic leucine zipper kinase). More particularly, the present invention relates to a diagnostic composition for gastric cancer comprising an agent measuring the expression level of CST1, DCC1, IFITM1 or MELK, a kit comprising the composition, a method for detecting the marker, and a method for screening a therapeutic agent for gastric cancer using the marker.

摘要翻译： 本发明涉及胃癌生物标志物，CST1（半胱氨酸蛋白酶抑制剂，2型家族），DCC1（姐妹染色单体内聚同系物1缺陷），IFITM1（干扰素诱导的跨膜蛋白1）或MELK（母体白蛋白亮氨酸拉链激酶） 。 更具体地，本发明涉及用于胃癌的诊断组合物，其包含测量CST1，DCC1，IFITM1或MELK的表达水平的试剂，包含该组合物的试剂盒，用于检测标记物的方法和用于筛选治疗 使用标记的胃癌药物。

公开(公告)号：US07718780B2

公开(公告)日：2010-05-18

申请号：US11393897

申请日：2006-03-31

申请人： Eun Young Song ,  Jae Wha Kim ,  Hee Gu Lee ,  Jong Seok Lim ,  Seung Chul Choi ,  Mi Young Cho ,  Kyoung Eun Baek ,  Jin Sook Kim ,  Jong Tae Kim ,  Do Young Yoon ,  Dur Han Kwon ,  Mi-Young Park ,  Young Il Yeom ,  Yong-Kyung Choe ,  Young-Jun Kim

发明人： Eun Young Song ,  Jae Wha Kim ,  Hee Gu Lee ,  Jong Seok Lim ,  Seung Chul Choi ,  Mi Young Cho ,  Kyoung Eun Baek ,  Jin Sook Kim ,  Jong Tae Kim ,  Do Young Yoon ,  Dur Han Kwon ,  Mi-Young Park ,  Young Il Yeom ,  Yong-Kyung Choe ,  Young-Jun Kim

IPC分类号： C12P21/08 ,  C07K16/00 ,  C12N5/06 ,  C12N5/16

CPC分类号： C07K16/18 ,  G01N33/574 ,  G01N33/6842 ,  G01N2500/00

摘要： The present invention relates to a monoclonal antibody specific for N-myc downstream regulated gene 2 (NDRG 2) protein, a cell line producing the monoclonal antibody, a method for measuring a quantity and quality of NDRG 2 protein, and a protein chip using the same. In the present invention, NDRG 2, a cancer-related factor is specifically expressed in dendritic cells differentiated from a monocyte of human peripheral blood. Accordingly, the monoclonal antibody specific for the NDRG 2 protein, the protein chip comprising the same and the method for measuring a quantity and quality of the NDRG 2 protein by using the same can be applied to elucidate characteristics of the dendritic cell and perform a research on the NDRG 2. Therefore, the present invention may help clinically to investigate and treat intractable diseases and cancers using the dendritic cell.

摘要翻译： 本发明涉及对N-myc下游调控基因2（NDRG 2）蛋白特异性的单克隆抗体，产生单克隆抗体的细胞系，测定NDRG2蛋白质的量和质量的方法，以及使用 相同。 在本发明中，癌细胞因子NDRG2特异性地表达于与人外周血单核细胞分化的树突状细胞中。 因此，可以应用对NDRG2蛋白质特异性的单克隆抗体，包含该NDRG2蛋白质的蛋白质芯片以及使用该方法来测定NDRG2蛋白质的量和质量的方法，以阐明树突状细胞的特征并进行研究 因此，本发明可以帮助临床上使用树突状细胞调查和治疗难治性疾病和癌症。

公开(公告)号：US08486905B2

公开(公告)日：2013-07-16

申请号：US12746722

申请日：2008-12-05

申请人： Misun Won ,  Kyung-Sook Chung ,  Young-Joo Kim ,  Shin-Jung Choi ,  Young Il Yeom ,  Seon-Young Kim ,  Kyung Bin Song ,  Hee Gu Lee ,  Eun Young Song ,  Young Ho Kim ,  Ho Kyung Chun ,  Chae-Ok Yun ,  Moon Hee Kim ,  Kyeong-Eun Jung ,  Sun-Jung Cho

发明人： Misun Won ,  Kyung-Sook Chung ,  Young-Joo Kim ,  Shin-Jung Choi ,  Young Il Yeom ,  Seon-Young Kim ,  Kyung Bin Song ,  Hee Gu Lee ,  Eun Young Song ,  Young Ho Kim ,  Ho Kyung Chun ,  Chae-Ok Yun ,  Moon Hee Kim ,  Kyeong-Eun Jung ,  Sun-Jung Cho

IPC分类号： C12N15/11 ,  C07H21/02

CPC分类号： G01N33/57484 ,  A61K31/7088 ,  A61K38/1709 ,  C12N15/1135 ,  C12N15/86 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2710/10343 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2500/00 ,  G01N2500/04

摘要： Provided are a composition for diagnosing cancer or screening an anticancer drug comprising an FLJ25416 gene or an antibody directed to a protein expressed from the FLJ25416 gene, a composition for treating cancer comprising an inhibitor of the gene or an inhibitor of the protein expressed from the gene and a pharmaceutically acceptable carrier, and a kit for diagnosing cancer comprising at least one of the FLJ25416 gene and the protein expressed from the FLJ25416 gene. The FLJ25416 gene is expressed at high level in specific cancer cells, and induces an increase in proliferation rate of normal cells. The expression of the gene is suppressed, which results in an inhibitory effect on cancer cell growth. Thus, the FLJ25416 gene can be used as a target gene for diagnosis or treatment of cancer.

摘要翻译： 提供了用于诊断癌症或筛选包含FLJ25416基因或针对从FLJ25416基因表达的蛋白质的抗体的抗癌药物的组合物，用于治疗癌症的组合物，其包含该基因的抑制剂或从该基因表达的蛋白质的抑制剂 和药学上可接受的载体，以及用于诊断癌症的试剂盒，其包含FLJ25416基因和从FLJ25416基因表达的蛋白质中的至少一种。 FLJ25416基因在特异性癌细胞中表达量高，诱导正常细胞增殖。 该基因的表达被抑制，这导致对癌细胞生长的抑制作用。 因此，FLJ25416基因可用作癌症诊断或治疗的靶基因。