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公开(公告)号：US06015568A
公开(公告)日：2000-01-18
申请号：US627480
申请日：1996-04-04
申请人： Evelyne Segot , Jean-Pierre Laugier
发明人： Evelyne Segot , Jean-Pierre Laugier
IPC分类号： A61K8/30 , A61K8/00 , A61K8/02 , A61K8/34 , A61K8/37 , A61K8/39 , A61K8/67 , A61K9/00 , A61K9/107 , A61K31/07 , A61K47/10 , A61K47/14 , A61P17/00 , A61Q19/00 , A61Q19/08 , A61K7/00
CPC分类号： A61K9/0014 , A61K31/07 , A61K47/10 , A61K47/14 , A61K8/671 , A61Q19/00 , A61K2800/31 , A61K2800/52 , A61Q19/08 , Y10S514/844 , Y10S514/845 , Y10S514/969
摘要： Anhydrous, stable retinol-based cosmetic or pharmaceutical composition for the skin. This composition contains solubilized retinol in an organic solution which is liquid at ambient temperature and which is chosen from the group comprising:i) aliphatic fatty alcohols having a branched chain at C.sub.16 -C.sub.20,ii) saturated alcoxylated fatty alcohols having a straight or branched chain at C.sub.16 -C.sub.20,iii) the diesters of dicarboxylic esters at C.sub.6 -C.sub.14 and of isopropyl alcohol, and mixtures of these solvents.This composition is intended for the treatment of skin disorders, and of acne in particular.
摘要翻译： 用于皮肤的无水稳定的视黄醇基化妆品或药物组合物。 该组合物在有机溶液中含有溶解的视黄醇，其在环境温度下为液体，并且选自包含以下的组：i）在C16-C20具有支链的脂族脂肪醇，ii）具有直链或支链的饱和烷氧基化脂肪醇 在C16-C20中，iii）C 6 -C 14的二羧酸酯和异丙醇的二酯，以及这些溶剂的混合物。 该组合物特别用于治疗皮肤疾病和痤疮。
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2.发明授权Pharmaceutical composition for topical application containing dithranol and preparation process 失效含有二硫酚的局部应用药物组合物及其制备方法
公开(公告)号：US5358716A
公开(公告)日：1994-10-25
申请号：US945703
申请日：1992-09-16
申请人： Jean-Pierre Laugier , Evelyne Segot
发明人： Jean-Pierre Laugier , Evelyne Segot
CPC分类号： A61K8/062 , A61K31/05 , A61K8/14 , A61K8/347 , A61K9/1272 , A61Q19/00 , Y10S514/863
摘要： Pharmaceutical composition for topical application to the skin, comprising an oil-in-water emulsion containing dithranol. This composition contains, in order to prevent the oxidation of the dithranol, nonionic vesicles prepared from a lipid phase containing at least one nonionic amphiphilic lipid. These vesicles are dispersed in the aqueous phase of the emulsion.
摘要翻译： 用于局部施用于皮肤的药物组合物，其包含含有双硫酚的水包油乳液。 为了防止二硫酚的氧化，该组合物含有由含有至少一种非离子两亲性脂质的脂质相制备的非离子囊泡。 这些囊泡分散在乳液的水相中。
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3.发明授权Process for improving the therapeutic efficacy of fat-soluble corticosteroids and composition for carrying out this process 失效用于改善脂溶性角质酸的治疗效果的方法和用于实施本方法的组合物
公开(公告)号：US5190936A
公开(公告)日：1993-03-02
申请号：US536891
申请日：1990-06-13
申请人： Jean-Pierre Laugier , Evelyne Segot , Francois Ringenbach , Jean-Thierry Simonnet , Philippe M. Touzan
发明人： Jean-Pierre Laugier , Evelyne Segot , Francois Ringenbach , Jean-Thierry Simonnet , Philippe M. Touzan
CPC分类号： A61K31/57 , A61K9/1272
摘要： The process consists in dissolving a corticosteroid in the lipid phase of nonionic amphiphilic lipid vesicles consisting of one or more lipid lamellae.Composition for carrying out the above process, in which the vesicles are dispersed in an aqueous phase D, have an average diameter of between 10 and 5,000 nm and contain as corticosteroids 17- and/or 21-mono- or -diesters of hydrocortisone, cortisone, prednisone, prednisolone or 6-methylprednisolone, the corticosteroids representing 0.5 to 2.5% by weight of the total lipids of the lamellae.
摘要翻译： 该过程包括将皮质类固醇溶解在由一种或多种脂质薄片组成的非离子两亲性脂质囊泡的脂质相中。 用于进行上述过程的组合物，其中囊泡分散在水相D中，其平均直径为10至5,000nm，并且含有作为皮质类固醇17和/或21-氢化可的松，可的松 ，泼尼松，泼尼松龙或6-甲基强的松龙，皮质类固醇占薄片总脂质重量的0.5〜2.5％。
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4.发明授权
公开(公告)号：US5679374A
公开(公告)日：1997-10-21
申请号：US367422
申请日：1994-12-30
IPC分类号： A61K8/04 , A61K8/00 , A61K8/14 , A61K8/19 , A61K8/27 , A61K8/30 , A61K8/34 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/39 , A61K8/41 , A61K8/44 , A61K8/49 , A61K8/60 , A61K8/63 , A61K8/67 , A61K8/85 , A61K8/86 , A61K8/92 , A61K9/127 , A61K9/133 , A61K31/575 , A61K45/00 , A61P17/12 , A61P17/18 , A61P29/00 , A61P31/04 , A61Q17/00 , A61Q19/00 , A61K7/00
CPC分类号： A61K8/368 , A61K8/14 , A61K8/347 , A61K8/671 , A61K9/127 , A61Q19/00 , Y10S514/846 , Y10S514/859
摘要： Compositions which comprise a first dispersion of lipid vesicles which are capable of penetrating into the deep layers of the skin and which contain at least one active agent chosen from antimicrobial agents, antiseptic agents, antibiotics, anti-inflammatory agents, anti-seborrhoeic agents, retinol and the derivatives thereof, for treating these deep layers, and a second dispersion of lipid vesicles which are capable of penetrating into the surface layers of the skin and which contain at least one active agent chosen from keratolytic agents, protective agents, moisturizing agents and antioxidants, for treating these surface layers, are particularly effective for the treatment of acne.
摘要翻译： 组合物，其包含脂质囊泡的第一分散体，其能够渗入皮肤深层并且含有至少一种活性剂，其选自抗微生物剂，防腐剂，抗生素，抗炎剂，抗脂溢剂，视黄醇 以及其衍生物，用于处理这些深层，以及能够渗入皮肤表层的脂质囊泡的第二分散体，并且含有至少一种选自角质分解剂，保护剂，保湿剂和抗氧化剂的活性剂 用于处理这些表面层对治疗痤疮特别有效。
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5.发明授权Slimming composition for topical treatment, containing two types of liposomes, and use thereof 失效用于局部治疗的减肥组合物，含有两种类型的脂质体及其用途
公开(公告)号：US5843476A
公开(公告)日：1998-12-01
申请号：US803146
申请日：1997-02-19
IPC分类号： A61K9/127 , A61K8/00 , A61K8/14 , A61K8/19 , A61K8/25 , A61K8/30 , A61K8/31 , A61K8/33 , A61K8/34 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/39 , A61K8/40 , A61K8/44 , A61K8/49 , A61K8/63 , A61K8/64 , A61K8/66 , A61K8/68 , A61K8/72 , A61K8/73 , A61K8/81 , A61K8/92 , A61K8/96 , A61K8/97 , A61P3/04 , A61Q19/06 , A61Q90/00
CPC分类号： A61K8/14 , A61K8/368 , A61K8/4953 , A61K8/63 , A61Q19/06 , Y10S514/869 , Y10S514/909
摘要： Compositions containing a first dispersion of lipid vesicles which are capable of penetrating into the deep layers of the skin and which contain at least one active agent chosen from lipolytic agents, draining agents and firming agents, for treating these deep layers, and a second dispersion of lipid vesicles which are capable of penetrating into the surface layers of the skin and which contain at least one active agent chosen from cutaneous surface treatment agents, exfoliation agents, smoothing agents and softening agents for the skin, for treating these surface layers, are effective as slimming agents for combating plumpness.
摘要翻译： 含有脂质囊泡的第一分散体的组合物能够渗入皮肤的深层并且含有至少一种选自脂肪分解剂，排液剂和紧肤剂的活性剂，用于处理这些深层，以及第二分散体 能够渗透到皮肤表层中并且含有选自皮肤表面处理剂，脱皮剂，平滑剂和皮肤软化剂中的至少一种活性剂用于处理这些表面层的脂质囊泡是有效的 减肥剂，以抵抗丰满度。
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6.发明授权Slimming composition for topical treatment, containing two types of liposomes, and use thereof 失效用于局部治疗的减肥组合物，含有两种类型的脂质体及其用途
公开(公告)号：US5637316A
公开(公告)日：1997-06-10
申请号：US367421
申请日：1994-12-30
IPC分类号： A61K9/127 , A61K8/00 , A61K8/14 , A61K8/19 , A61K8/25 , A61K8/30 , A61K8/31 , A61K8/33 , A61K8/34 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/39 , A61K8/40 , A61K8/44 , A61K8/49 , A61K8/63 , A61K8/64 , A61K8/66 , A61K8/68 , A61K8/72 , A61K8/73 , A61K8/81 , A61K8/92 , A61K8/96 , A61K8/97 , A61P3/04 , A61Q19/06 , A61Q90/00
CPC分类号： A61K8/14 , A61K8/368 , A61K8/4953 , A61K8/63 , A61Q19/06 , Y10S514/869 , Y10S514/909
摘要： Compositions containing a first dispersion of lipid vesicles which are capable of penetrating into the deep layers of the skin and which contain at least one active agent chosen from lipolytic agents, draining agents and firming agents, for treating these deep layers, and a second dispersion of lipid vesicles which are capable of penetrating into the surface layers of the skin and which contain at least one active agent chosen from cutaneous surface treatment agents, exfoliation agents, smoothing agents and softening agents for the skin, for treating these surface layers, are effective as slimming agents for combating plumpness.
摘要翻译： 含有脂质囊泡的第一分散体的组合物能够渗入皮肤的深层并且含有至少一种选自脂肪分解剂，排液剂和紧肤剂的活性剂，用于处理这些深层，以及第二分散体 能够渗透到皮肤表层中并且含有选自皮肤表面处理剂，脱皮剂，平滑剂和皮肤软化剂中的至少一种活性剂用于处理这些表面层的脂质囊泡是有效的 减肥剂，以抵抗丰满度。
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7.发明授权
公开(公告)号：US5607692A
公开(公告)日：1997-03-04
申请号：US366739
申请日：1994-12-30
申请人： Alain Ribier , Jean-Thierry Simonnet , Chantal Fanchon , Laurence Arnaud-Sebillotte , Evelyne Segot
发明人： Alain Ribier , Jean-Thierry Simonnet , Chantal Fanchon , Laurence Arnaud-Sebillotte , Evelyne Segot
IPC分类号： A61K9/127 , A61K8/00 , A61K8/11 , A61K8/14 , A61K8/19 , A61K8/20 , A61K8/30 , A61K8/33 , A61K8/34 , A61K8/35 , A61K8/36 , A61K8/365 , A61K8/368 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/49 , A61K8/55 , A61K8/60 , A61K8/64 , A61K8/67 , A61K8/72 , A61K8/73 , A61K8/86 , A61K8/92 , A61K8/97 , A61K8/98 , A61K45/00 , A61P43/00 , A61Q1/02 , A61Q19/00 , A61Q19/02 , A61K7/00
CPC分类号： A61K8/347 , A61K8/14 , A61K8/34 , A61K8/365 , A61K8/368 , A61K8/37 , A61K8/42 , A61K8/44 , A61K8/4926 , A61K8/4973 , A61K8/60 , A61K8/671 , A61K8/676 , A61K8/732 , A61K8/735 , A61K8/97 , A61K8/987 , A61Q19/02 , A61K2800/782 , Y10S514/844
摘要： A composition comprising a first dispersion of lipid vesicles which are capable of penetrating into the deep layers of the skin and which contain at least one active agent selected from the group consisting of anti-pigmenting agents, depigmenting agents and tyrosinase inhibitors, for treating these deep layers, and a second dispersion of lipid vesicles which are capable of penetrating into the surface layers of the skin and which contain at least one active agent selected from the group consisting of keratolytic agents, moisturizing agents and protective agents, for treating these surface layers, is found effective for depigmenting skin.
摘要翻译： 一种组合物，其包含脂质囊泡的第一分散体，其能够渗透到皮肤的深层中并且含有至少一种选自抗着色剂，脱色剂和酪氨酸酶抑制剂的活性剂，用于治疗这些深层 层和脂质囊泡的第二分散体，其能够渗入皮肤的表层，并且含有至少一种活性剂，其选自角质分解剂，保湿剂和保护剂，用于处理这些表面层， 被发现有效脱色皮肤。
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