公开(公告)号：US20180179562A1

公开(公告)日：2018-06-28

申请号：US15898369

申请日：2018-02-16

Applicant: AJINOMOTO CO., INC. ,  EVOLVA SA

Inventor： Markus Schwab ,  Maud Babau ,  David Fischer ,  Anaelle Hatsch ,  Sabina de Andrade Pereira Tavares ,  Curt Aime Friis Nielsen ,  Jens Klein ,  Corina Daniela Wirdnam

IPC: C12P13/00 ,  C12P1/02 ,  C12N1/16 ,  C12N9/12 ,  C12P7/64

CPC classification number: C12P13/001 ,  C07C215/10 ,  C07F9/09 ,  C12N1/16 ,  C12N9/12 ,  C12N9/1205 ,  C12P1/02 ,  C12P7/6481 ,  C12Y207/01091 ,  C12Y207/11001

Abstract: A method for producing an objective substance such as phytosphingosine and sphinganine using yeast is provided. An objective substance is produced by cultivating yeast having an ability to produce the objective substance and modified so that the expression and/or activities of proteins encoded by LCB4 and CKA2 genes are reduced in a culture medium, and collecting the objective substance from cells of the yeast and/or the culture medium.

公开(公告)号：US11111511B2

公开(公告)日：2021-09-07

申请号：US15898369

申请日：2018-02-16

Applicant: AJINOMOTO CO., INC. ,  EVOLVA SA

Inventor： Markus Schwab ,  Maud Babau ,  David Fischer ,  Anaelle Hatsch ,  Sabina de Andrade Pereira Tavares ,  Curt Aime Friis Nielsen ,  Jens Klein ,  Corina Daniela Wirdnam

IPC: C12P13/00 ,  C12N9/12 ,  C12N1/16 ,  C12P1/02 ,  C12P7/64 ,  C07C215/10 ,  C07F9/09

Abstract: A method for producing an objective substance such as phytosphingosine and sphinganine using yeast is provided. An objective substance is produced by cultivating yeast having an ability to produce the objective substance and modified so that the expression and/or activities of proteins encoded by LCB4 and CKA2 genes are reduced in a culture medium, and collecting the objective substance from cells of the yeast and/or the culture medium.

公开(公告)号：US20180355001A1

公开(公告)日：2018-12-13

申请号：US15778804

申请日：2016-11-25

Applicant: Evolva SA

Inventor： Thomas Tange ,  Jens Klein ,  Federico Brianza

IPC: C07K14/435 ,  C12N15/62 ,  C12N9/88 ,  C12N15/81

CPC classification number: C07K14/435 ,  C12N9/88 ,  C12N15/62 ,  C12N15/81 ,  C12Y402/03009

Abstract: The invention relates to recombinant microorganisms and methods for producing terpene compounds, terpenoid compounds, and precursors thereof derived from (2Z,6E)-farnesyl diphosphate.