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公开(公告)号：US20180179562A1
公开(公告)日：2018-06-28
申请号：US15898369
申请日：2018-02-16
申请人： AJINOMOTO CO., INC. , EVOLVA SA
发明人： Markus Schwab , Maud Babau , David Fischer , Anaelle Hatsch , Sabina de Andrade Pereira Tavares , Curt Aime Friis Nielsen , Jens Klein , Corina Daniela Wirdnam
CPC分类号： C12P13/001 , C07C215/10 , C07F9/09 , C12N1/16 , C12N9/12 , C12N9/1205 , C12P1/02 , C12P7/6481 , C12Y207/01091 , C12Y207/11001
摘要： A method for producing an objective substance such as phytosphingosine and sphinganine using yeast is provided. An objective substance is produced by cultivating yeast having an ability to produce the objective substance and modified so that the expression and/or activities of proteins encoded by LCB4 and CKA2 genes are reduced in a culture medium, and collecting the objective substance from cells of the yeast and/or the culture medium.
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公开(公告)号：US11111511B2
公开(公告)日：2021-09-07
申请号：US15898369
申请日：2018-02-16
申请人： AJINOMOTO CO., INC. , EVOLVA SA
发明人： Markus Schwab , Maud Babau , David Fischer , Anaelle Hatsch , Sabina de Andrade Pereira Tavares , Curt Aime Friis Nielsen , Jens Klein , Corina Daniela Wirdnam
摘要： A method for producing an objective substance such as phytosphingosine and sphinganine using yeast is provided. An objective substance is produced by cultivating yeast having an ability to produce the objective substance and modified so that the expression and/or activities of proteins encoded by LCB4 and CKA2 genes are reduced in a culture medium, and collecting the objective substance from cells of the yeast and/or the culture medium.
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公开(公告)号：US11155841B2
公开(公告)日：2021-10-26
申请号：US15898358
申请日：2018-02-16
申请人： AJINOMOTO CO., INC. , EVOLVA SA
发明人： Markus Schwab , Corina Daniela Wirdnam , Thomas Oestergaard Tange , Maud Babau , Anaelle Hatsch , Fanny Delegrange , David Fischer , Sabina de Andrade Pereira Tavares
摘要： A method for producing an objective substance such as sphingoid bases and sphingolipids using yeast is provided. An objective substance is produced by cultivating yeast having an ability to produce the objective substance in a culture medium containing an additive that is able to associate with, bind to, solubilize, and/or capture the objective substance, and collecting the objective substance from cells of the yeast and/or the culture medium.
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公开(公告)号：US20230374559A1
公开(公告)日：2023-11-23
申请号：US18351225
申请日：2023-07-12
申请人： AJINOMOTO CO., INC. , EVOLVA SA
发明人： Vsevolod Aleksandrovich Serebrianyi , Olga Aleksandrovna Sofyanovich , Anna Mikhailovna Ozerova , Takashi Kakiyama , Nobuhiro Hiratsuka , Yasuhiro Tateyama , Corina Wirdnam , Sabina de Andrade Pereira TAVARES , Markus Schwab
CPC分类号： C12P13/02 , C12P13/001 , C12N15/81 , C12R2001/865
摘要： A method for producing an objective substance, such as phytosphingosine (PHS) and phytoceramide (PHC), comprising a desired alkyl chain using yeast is provided. The objective substance is produced by cultivating yeast having an ability to produce the objective substance in a culture medium containing a fatty acid.
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公开(公告)号：US20180179563A1
公开(公告)日：2018-06-28
申请号：US15898358
申请日：2018-02-16
申请人： AJINOMOTO CO., INC. , EVOLVA SA
发明人： Markus Schwab , Corina Daniela Wirdnam , Thomas Oestergaard Tange , Maud Babau , Anaelle Hatsch , Fanny Delegrange , David Fischer , Sabina de Andrade Pereira Tavares
CPC分类号： C12P13/02 , C12N2500/05 , C12N2500/30 , C12P13/001 , C12Y101/01102 , C12Y114/13169 , C12Y114/18 , C12Y203/01 , C12Y203/01024 , C12Y203/0105 , C12Y203/01199 , C12Y204/0108 , C12Y207/01091 , C12Y207/11001 , C12Y305/01023 , C12Y403/01017
摘要： A method for producing an objective substance such as sphingoid bases and sphingolipids using yeast is provided. An objective substance is produced by cultivating yeast having an ability to produce the objective substance in a culture medium containing an additive that is able to associate with, bind to, solubilize, and/or capture the objective substance, and collecting the objective substance from cells of the yeast and/or the culture medium.
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公开(公告)号：US09828617B2
公开(公告)日：2017-11-28
申请号：US14421872
申请日：2013-08-13
发明人： Michael Naesby , Christophe Folly , Curt Aimé Friis Nielsen , Anaelle Hatsch , Markus Schwab , Oskar Zelder , Stefan Haefner , Hartwig Schroeder , Birgit Hoff , Andrea Molt , Klaus Ditrich , Michael Breuer , Holger Hartmann , Karsten Koerber
IPC分类号： C12N15/53 , C12P17/12 , C12N9/02 , C12N9/90 , C12N15/52 , C12P17/10 , C12P17/18 , C07D209/90 , C07D487/06 , C07K16/40 , C12N9/10
CPC分类号： C12P17/12 , C07D209/90 , C07D487/06 , C07K16/40 , C12N9/0004 , C12N9/001 , C12N9/1007 , C12N9/1085 , C12N9/90 , C12N15/52 , C12P17/10 , C12P17/182 , C12Y205/01
摘要： Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.
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公开(公告)号：US20150211036A1
公开(公告)日：2015-07-30
申请号：US14421872
申请日：2013-08-13
发明人： Michael Naesby , Christophe Folly , Curt Aimé Friis Nielsen , Anaelle Hatsch , Markus Schwab , Oskar Zelder , Stefan Haefner , Hartwig Schroeder , Birgit Hoff , Andrea Molt , Klaus Ditrich , Michael Breuer , Holger Hartmann , Karsten Koerber
IPC分类号： C12P17/12 , C12N9/02 , C07D209/90 , C12P17/10 , C07K16/40 , C07D487/06 , C12N9/10 , C12N9/90
CPC分类号： C12P17/12 , C07D209/90 , C07D487/06 , C07K16/40 , C12N9/0004 , C12N9/001 , C12N9/1007 , C12N9/1085 , C12N9/90 , C12N15/52 , C12P17/10 , C12P17/182 , C12Y205/01
摘要： Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.
摘要翻译： 用于重组生产角鲨烯型生物碱如环圈子，festuclavine，agroclavine，chanoclavine和chanoclavine醛的微生物和方法，以及多肽，多核苷酸和包含这样的多核苷酸的载体，其可以用于制造棒状的方法 提供生物碱。
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