公开(公告)号：US12031991B2

公开(公告)日：2024-07-09

申请号：US16977003

申请日：2019-02-28

申请人： EVONIK OPERATIONS GMBH

发明人： Monika Flügel ,  Stefan Pelzer ,  Frank Thiemann ,  Filip Van Immerseel ,  Richard Ducatelle ,  Evy Goossens ,  Bart Devreese ,  Griet Debyser

IPC分类号： G01N33/68 ,  G01N33/543

CPC分类号： G01N33/6893 ,  G01N33/543 ,  G01N33/54306 ,  G01N33/54388 ,  G01N2333/79 ,  G01N2800/06

摘要： The present invention pertains to an in vitro method for detecting intestinal barrier failure in an avian population, the method comprising the following steps: a) collecting a pooled fecal sample deriving from an avian population and b) determining the amount of at least one protein marker contained in said sample; wherein the at least one protein marker comprises or consists of an acute phase protein or a functional fragment thereof, and wherein an increased amount of said at least one protein marker contained in said sample versus a reference sample indicates intestinal barrier failure.

公开(公告)号：US11643696B2

公开(公告)日：2023-05-09

申请号：US16612398

申请日：2018-05-09

申请人： EVONIK OPERATIONS GMBH

发明人： Monika Flügel ,  Stefan Pelzer ,  Filip Van Immerseel ,  Richard Ducatelle ,  Evy Goossens ,  Sarah Hark ,  Frank Thiemann ,  Florian Böhl

IPC分类号： C12Q1/68 ,  C12Q1/689 ,  C12Q1/686

CPC分类号： C12Q1/689 ,  C12Q1/686

摘要： The present invention relates to a method for detecting C. perfringens induced diseases in animals, the method comprising: a) collecting sample material of a specific animal or of a specific group of animals at consecutive points in time; b) determining the amount of a first marker and a second marker contained in the sample material; and c) determining the ratio of the first marker to the second marker contained in the sample material; wherein the first marker comprises a polynucleotide sequence being specific for the C. perfringens sub-species inducing the targeted disease; and the second marker comprises a polynucleotide being specific for the species C. perfringens; and wherein an increase in the ratio of the first marker to the second marker in the analyzed sample material over time is an indication of the targeted disease.

公开(公告)号：US20220168363A1

公开(公告)日：2022-06-02

申请号：US17429905

申请日：2020-02-10

申请人： Evonik Operations GmbH

发明人： Lorena STANNEK-GÖBEL ,  Stefan Pelzer ,  Thomas Berngruber ,  Claudia Borgmeier ,  Stella Molck

IPC分类号： A61K35/742 ,  A23K10/18 ,  C12N1/20 ,  A23K50/30 ,  A23K50/75 ,  A23K50/80 ,  A23L33/135

摘要： Bacillaene producing bacteria and compositions containing bacillaene producing bacteria can be used as probiotic feed ingredients. Bacillaene or derivatives thereof can be used for treating bacterial diseases.

公开(公告)号：US11173184B2

公开(公告)日：2021-11-16

申请号：US15607534

申请日：2017-05-29

申请人： Evonik Operations GmbH

发明人： Daniel Petri ,  Stefan Pelzer ,  Jessica Kleinbölting ,  Stella Molck ,  Maike Kipker ,  Claudia Borgmeier ,  Sandra Herbold ,  Guido Meurer ,  Rose Whelan ,  Kiran Doranalli

IPC分类号： A61K35/742 ,  C12N1/20 ,  A61K35/00 ,  A01N63/00 ,  A01N63/22 ,  C12R1/125

摘要： The current invention concerns a new B. subtilis strain with strong inhibition of C. perfringens and its use as a probiotic.

公开(公告)号：US20220217998A1

公开(公告)日：2022-07-14

申请号：US17608274

申请日：2020-04-28

申请人： Evonik Operations GmbH

发明人： Ursula RIESEN ,  Frank Wilz ,  Lorena Stannek-Göbel ,  Adriana Barri ,  Stefan Pelzer ,  Ulrike Kottke ,  Christoph Kobler ,  Achim Fischer ,  Vincent Hess

IPC分类号： A23K10/18 ,  A23K20/105 ,  A23K20/22 ,  A23K40/10 ,  A23K50/75 ,  A61K35/742 ,  A61K35/744 ,  A61K9/00

摘要： Compositions, in particular compacted compositions, contain at least one betaine salt and at least one feed additive; and can be used for providing the feed additive, in particular probiotics, to drinking water or rearing water.