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公开(公告)号：US09688658B1
公开(公告)日：2017-06-27
申请号：US15501329
申请日：2016-02-23
Applicant: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
Inventor： Paolo Stabile , Diego Rasia , Nicola Faccin , Moreno Bertolazzi
IPC: C07D401/12
CPC classification number: C07D401/12 , C07B2200/07
Abstract: An efficient process for increasing the optical purity of the active pharmaceutical ingredient Esomeprazole, by means of a substantially quantitative and selective precipitation and removal of Omeprazole is provided.
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公开(公告)号：US08765962B1
公开(公告)日：2014-07-01
申请号：US13924094
申请日：2013-06-21
Applicant: F.I.S.—Fabbrica Italiana Sintetici S.p.A.
Inventor： Paolo Stabile , Marco Galvagni
IPC: C07D213/50
CPC classification number: C07D213/52 , C07D213/50
Abstract: The present invention relates to an efficient process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, an intermediate of the synthesis of Etoricoxib. Water is employed as reaction medium.
Abstract translation: 本发明涉及一种合成Etoricoxib的中间体1-（6-甲基吡啶-3-基）-2- [4-（甲基磺酰基）苯基]乙酮的有效方法。 水用作反应介质。
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公开(公告)号：US11267791B2
公开(公告)日：2022-03-08
申请号：US17263642
申请日：2019-07-25
Applicant: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
Inventor： Nicolas Tesson , Jordi De Mier Vinue , Paolo Stabile , Pierluigi Padovan , Matteo De Poli , Angelo Restelli
IPC: C07D231/46
Abstract: Object of the present invention is a highly stable crystalline form of Eltrombopag (ETP) monoethanolamine salt, named Form D1, having the highest thermodynamically stability with excellent non-hygroscopicity, and particularly well suitable for pharmaceutical purposes, with related process.
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Patent Agency Ranking
公开(公告)号：US11214547B2
公开(公告)日：2022-01-04
申请号：US17263636
申请日：2019-07-25
Applicant: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
Inventor： Nicolas Tesson , Jordi De Mier Vinue , Paolo Stabile , Pierluigi Padovan , Matteo De Poli , Angelo Restelli
IPC: C07D231/46
Abstract: Object of the present invention is a better crystalline form of Eltrombopag (ETP) monoethanolamine salt, named Form D, stable, suitable for pharmaceutical purposes, and with the highest solubility in water and excellent non-hygroscopicity, then the related process and intermediates thereof.
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5.发明申请公开(公告)号：US20140206882A1
公开(公告)日：2014-07-24
申请号：US13924094
申请日：2013-06-21
Applicant: F.I.S. -Fabbrica Italiana Sintetici S.p.A.
Inventor： Paolo Stabile , Marco Galvagni
IPC: C07D213/52
CPC classification number: C07D213/52 , C07D213/50
Abstract: The present invention relates to an efficient process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, an intermediate of the synthesis of Etoricoxib. Water is employed as reaction medium.
Abstract translation: 本发明涉及一种合成Etoricoxib的中间体1-（6-甲基吡啶-3-基）-2- [4-（甲基磺酰基）苯基]乙酮的有效方法。 水用作反应介质。
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公开(公告)号：US11434197B2
公开(公告)日：2022-09-06
申请号：US17059594
申请日：2019-06-07
Applicant: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
Inventor： Stefano Fogal , Paolo Stabile , Pierluigi Padovan , Matteo De Poli , Angelo Restelli
IPC: C07C227/20 , C12N9/04 , C07C227/18 , C07C271/22 , C07C269/06 , C12P13/04 , C07C229/36
Abstract: The present invention relates to a process for the preparation of Droxidopa by means of an improved enzymatic reduction of a compound of formula (II): (II), wherein R1, R2 is independent hydrogen, acetyl, R3 is hydrogen, a C1-C4 linear or branched alkyl group and R4 is hydrogen or an amine protecting group.
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7.发明授权公开(公告)号：US09428486B1
公开(公告)日：2016-08-30
申请号：US14745481
申请日：2015-06-22
Applicant: F.I.S. - Fabbrica Italiana Sintetici S.p.A.
Inventor： Paolo Stabile , Moreno Bertolazzi , Nicola Faccin , Diego Rasia
IPC: C07D401/00 , C07D401/12 , C07C37/00
CPC classification number: C07D401/12 , C07B2200/07 , C07C37/00
Abstract: Object of the present invention is an improved process for the preparation of Esomeprazole (S)-BINOL complex which is a key intermediate for the synthesis of Esomeprazole and salts thereof.
Abstract translation: 本发明的目的是制备用于合成艾美拉唑及其盐的关键中间体的埃索美拉唑（S）-BINOL络合物的改进方法。
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公开(公告)号：US08742118B2
公开(公告)日：2014-06-03
申请号：US13654437
申请日：2012-10-18
Applicant: F.I.S.—Fabbrica Italiana Sintetici S.p.A.
Inventor： Francesco Fontana , Paolo Stabile
IPC: C07D213/22 , A61K31/44
CPC classification number: C07F3/02 , C07D213/64
Abstract: Methods for the synthesis of 2-alkoxy-5-(pyridin-2-yl)pyridine of formula I or salts thereof are provided.
Abstract translation: 提供了合成式I的2-烷氧基-5-（吡啶-2-基）吡啶或其盐的方法。
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