公开(公告)号：US20240279685A1

公开(公告)日：2024-08-22

申请号：US18004403

申请日：2021-07-06

Applicant: FLAGSHIP PIONEERING INNOVATIONS V, INC.

Inventor： Benhur Lee ,  Michael Travis Mee ,  Jagesh V. Shah ,  Kyle Marvin Trudeau

IPC: C12N15/88 ,  A61K9/51 ,  C07K14/005 ,  C12N5/071 ,  C12N7/00

CPC classification number: C12N15/88 ,  A61K9/5184 ,  C07K14/005 ,  C12N5/0602 ,  C12N7/00 ,  C12N2740/16043 ,  C12N2760/18222

Abstract: The present disclosure provides, at least in part, methods and compositions for producing fusosomes. In some embodiments, a producer cell for producing fusosomes comprises an exogenous or overexpresed cathepsin molecule. In some embodiments, these cells generate an increased level of active fusogen, leading to a higher proportion of fusogenically active fusosomes.