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    Optical platelet counter method
    2.
    发明授权
    Optical platelet counter method 有权

    公开(公告)号：US10132738B2

    公开(公告)日：2018-11-20

    申请号：US15633695

    申请日：2017-06-26

    申请人： FOCE Technology International BV

    发明人： Thomas Obrien ,  Hendrik Dijkstra ,  Marcel F Schemmann

    IPC分类号： G01N15/14 ,  G02B27/00 ,  G06K9/52 ,  G06K9/00 ,  G06K9/78 ,  G02B21/36 ,  G02B21/06 ,  G01N15/00 ,  G01N15/10

    摘要： Platelets or blood cells are detected in a fluid sample by adjusting a focal depth of a microscope through a range of values, the microscope having a mounted sample and an objective lens adapted with one or both of (a) a spherical aberration correction unmatched to a utilized cover plate for the sample, or (2) a numerical aperture unmatched to a utilized illumination source for the sample. Images are recorded at different specific focal depths and in multiple z planes of a fluid bearing the platelets, where the position of platelets may overlap on different of the multiple z planes that are recorded, the images recorded through the cover plate, thus causing the generation of a specific light-dark pattern indicative of platelets at particular positions and at multiple depths in the fluid media. The images are analyzed for the specific light-dark pattern.

    OPTICAL PLATELET COUNTER METHOD
    4.
    发明申请
    OPTICAL PLATELET COUNTER METHOD 有权
    光学计数器方法

    公开(公告)号：US20140205176A1

    公开(公告)日：2014-07-24

    申请号：US14223784

    申请日：2014-03-24

    申请人： FOCE Technology International BV

    发明人： Thomas Obrien ,  Hendrik Dijkstra ,  Marcel F Schemmann

    IPC分类号： G06K9/00

    CPC分类号： G01N15/1463 ,  G01N15/1434 ,  G01N15/1475 ,  G01N2015/0065 ,  G01N2015/0084 ,  G01N2015/1006 ,  G01N2015/1445 ,  G01N2015/1452 ,  G01N2015/1486 ,  G02B21/06 ,  G02B21/365 ,  G02B21/367 ,  G02B27/0025 ,  G06K9/00134 ,  G06K9/52 ,  G06K9/78

    摘要： Platelets or blood cells are detected in a fluid sample by adjusting a focal depth of a microscope through a range of values, the microscope having a mounted sample and an objective lens adapted with one or both of (a) a spherical aberration correction unmatched to a utilized cover plate for the sample, or (2) a numerical aperture unmatched to a utilized illumination source for the sample. Images are recorded at different specific focal depths and in multiple z planes of a fluid bearing the platelets, where the position of platelets may overlap on different of the multiple z planes that are recorded, the images recorded through the cover plate, thus causing the generation of a specific light-dark pattern indicative of platelets at particular positions and at multiple depths in the fluid media. The images are analyzed for the specific light-dark pattern.

    摘要翻译： 通过调整显微镜的焦点深度在一定范围内，在流体样品中检测血小板或血细胞，显微镜具有安装的样品和适于以下（a）球面像差校正与 用于样品的盖板，或（2）与样品的利用的照明源无法比拟的数值孔径。 在不同的特定焦点深度和承载血小板的流体的多个z平面中记录图像，其中血小板的位置可以在记录的多个z平面上的不同位置上重叠，通过盖板记录的图像，从而导致生成 具体指示在流体介质中的特定位置和多个深度处的血小板的特定光暗图案。 分析图像的特定亮暗图案。