公开(公告)号：US11578118B2

公开(公告)日：2023-02-14

申请号：US16757707

申请日：2018-10-19

申请人： Fred Hutchinson Cancer Center

发明人： Justin J. Taylor ,  Howell F. Moffett

IPC分类号： A61K35/17 ,  C07K16/10 ,  C07K16/08 ,  C07K16/12 ,  C07K16/24 ,  C12N15/86 ,  C12N15/90

摘要： Systems and methods to genetically modify B cells to express selected antibodies are described. The systems and methods can be used to: obviate the need for classical vaccinations; provide protection against infectious agents for which no vaccinations are currently available; provide protection against infectious agents when patients are otherwise immune-suppressed; and/or provide a benefit provided by a therapeutic antibody, such as in the treatment of autoimmune disorders.

公开(公告)号：US20240285797A1

公开(公告)日：2024-08-29

申请号：US18412351

申请日：2024-01-12

申请人： FRED HUTCHINSON CANCER CENTER

发明人： Matthias Stephan ,  Howell F. Moffett

IPC分类号： A61K48/00 ,  A61K35/14 ,  C07K14/705 ,  C12N9/22 ,  C12N15/88

CPC分类号： A61K48/005 ,  C07K14/705 ,  C12N9/22 ,  C12N15/88 ,  A61K35/14

摘要： Compositions and methods that rapidly and selectively modify hematopoietic stem cells (or cells derived therefrom) to achieve therapeutic objectives by providing for transient expression of nucleic acids are described. The transient expression leads to permanent therapeutic changes in the modified cells, referred to herein as “hit and run” effects.

公开(公告)号：US11872195B2

公开(公告)日：2024-01-16

申请号：US16222942

申请日：2018-12-17

申请人： FRED HUTCHINSON CANCER CENTER

发明人： Matthias Stephan ,  Howell F. Moffett

IPC分类号： A61K48/00 ,  C12N9/22 ,  C07K14/705 ,  C12N15/88 ,  A61K35/14

CPC分类号： A61K48/005 ,  C07K14/705 ,  C12N9/22 ,  C12N15/88 ,  A61K35/14

摘要： Compositions and methods that rapidly and selectively modify hematopoietic stem cells (or cells derived therefrom) to achieve therapeutic objectives by providing for transient expression of nucleic acids are described. The transient expression leads to permanent therapeutic changes in the modified cells, referred to herein as “hit and run” effects.

公开(公告)号：US20230250159A1

公开(公告)日：2023-08-10

申请号：US18166151

申请日：2023-02-08

申请人： Fred Hutchinson Cancer Center

发明人： Justin J. Taylor ,  Howell F. Moffett

IPC分类号： C07K16/10 ,  A61K35/17 ,  C07K16/08 ,  C07K16/12 ,  C07K16/24 ,  C12N15/86 ,  C12N15/90

CPC分类号： C07K16/1027 ,  A61K35/17 ,  C07K16/082 ,  C07K16/085 ,  C07K16/087 ,  C07K16/088 ,  C07K16/1018 ,  C07K16/1045 ,  C07K16/1282 ,  C07K16/241 ,  C12N15/86 ,  C12N15/907 ,  C12N2310/20 ,  C12N2510/00 ,  C12N2750/14143 ,  C12N2800/80

摘要： Systems and methods to genetically modify B cells to express selected antibodies are described. The systems and methods can be used to: obviate the need for classical vaccinations; provide protection against infectious agents for which no vaccinations are currently available; provide protection against infectious agents when patients are otherwise immune-suppressed; and/or provide a benefit provided by a therapeutic antibody, such as in the treatment of autoimmune disorders.