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    COMPOUND AND LABELED BIOLOGICAL SUBSTANCE USING THE SAME
    1.
    发明公开
    COMPOUND AND LABELED BIOLOGICAL SUBSTANCE USING THE SAME 审中-公开

    公开(公告)号：US20240165240A1

    公开(公告)日：2024-05-23

    申请号：US18411053

    申请日：2024-01-12

    Applicant: FUJIFILM Corporation

    Inventor： Naoka HAMADA ,  Kenji SHIROKANE ,  Yuji YOSHIMITSU

    IPC: A61K47/54 ,  A61K47/65 ,  A61K47/68 ,  G01N33/533 ,  G01N33/58

    CPC classification number: A61K47/545 ,  A61K47/65 ,  A61K47/6873 ,  G01N33/533 ,  G01N33/582

    Abstract: There are provided a compound having a phosphor moiety and a structure represented by General Formula (I), and a labeled biological substance.




    In the formula, A1 represents a structure represented by General Formula (a1),



    A2 represents a structure represented by General Formula (a2), and
    B represents a structure represented by General Formula (b),








    In the formulae, X1 to X6 represent —O—, —S—, >NR1, or >CR2R3.
    R1 to R3 represent a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an acyl group, an aryl group, a heteroaryl group, —NR9R10, —OR11, or an anionic group.
    R9 to R11 represent a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an acyl group, an aryl group, or a heteroaryl group.
    Y1 represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, or a heteroaryl group.
    L1 represents a divalent linking group.
    l, m, n, and p are an integer of 1 or more.
    * represents a bonding site.

    COMPOUND AND LABELED BIOLOGICAL SUBSTANCE USING THE SAME
    3.
    发明公开
    COMPOUND AND LABELED BIOLOGICAL SUBSTANCE USING THE SAME 审中-公开

    公开(公告)号：US20240182383A1

    公开(公告)日：2024-06-06

    申请号：US18411055

    申请日：2024-01-12

    Applicant: FUJIFILM Corporation

    Inventor： Kenji SHIROKANE ,  Yuji YOSHIMITSU ,  Naoka HAMADA

    IPC: C07B59/00

    CPC classification number: C07B59/008 ,  C07B2200/05

    Abstract: There are provided a compound having at least two phosphor moieties and a structure represented by General Formula (I), and a labeled biological substance.




    In the formula, X1 to X3 represent —O—, —S—, >NR1, or >CR2R3. R1 to R3 represent a hydrogen atom or a substituent. La and Lb represents a single bond or a divalent linking group. n is an integer of 2 or more.
    However, at least one among R1 to R3, which are contained in a structure parenthesized in ( )n, La, and Lb includes -(L-O)gRE, where -(L-O)gRE in each of these groups is not bonded to at least any one of a phosphor or a biological substance.
    L represents an alkylene group, RE represents a hydrogen atom or an alkyl group, and g is 1 to 24.
    * represents a bonding site.

    METHOD FOR PRODUCING PEPTIDE COMPOUND, REAGENT FOR FORMING PROTECTIVE GROUP, AND HYDRAZINE DERIVATIVE
    4.
    发明申请
    METHOD FOR PRODUCING PEPTIDE COMPOUND, REAGENT FOR FORMING PROTECTIVE GROUP, AND HYDRAZINE DERIVATIVE 有权

    公开(公告)号：US20220185841A1

    公开(公告)日：2022-06-16

    申请号：US17654060

    申请日：2022-03-08

    Applicant: FUJIFILM CORPORATION

    Inventor： Yuji YOSHIMITSU

    IPC: C07K1/06 ,  C07C243/28

    Abstract: Provided are a method for producing a peptide compound including a step of using a hydrazine derivative represented by Formula (1); a reagent for forming a protective group including the compound; and a hydrazine derivative. In Formula (1), a ring A represents an aromatic hydrocarbon ring or an aromatic heterocyclic ring, R represents a hydrogen atom, an amino protective group, an amino acid residue, or a peptide residue, k represents an integer of 1 to 5, n represents 1 or 2, and RA's each independently represent an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group.

    THIONUCLEOSIDE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION
    6.
    发明申请
    THIONUCLEOSIDE DERIVATIVE OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION 审中-公开

    公开(公告)号：US20170233429A1

    公开(公告)日：2017-08-17

    申请号：US15581834

    申请日：2017-04-28

    Applicant: FUJIFILM Corporation

    Inventor： Hidenobu KUNIYOSHI ,  Daisuke NAKAGAWA ,  Takuya MATSUMOTO ,  Yuji YOSHIMITSU

    IPC: C07H19/10

    CPC classification number: C07H19/10 ,  A61K31/7068 ,  A61P35/00 ,  A61P35/02

    Abstract: Disclosed are a compound and a pharmaceutical composition that exhibit an excellent drug efficacy against a tumor, in particular a tumor which has acquired resistance to gemcitabine. Specifically, provided is a thionucleoside derivative represented by General Formula [1] (in the formula, R1 represents a hydroxyl group which may be protected, a C1-20 alkoxy group which may be substituted, or the like; R2 represents a C1-20 alkoxy group which may be substituted, a C3-8 cycloalkoxy group which may be substituted, or the like; and R3 represents a hydrogen atom or the like); or a salt thereof. Further, provided is a pharmaceutical composition containing such a thionucleoside derivative or a salt thereof.

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