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    KIT AND METHOD FOR MEASURING MEASUREMENT TARGET SUBSTANCE IN BIOLOGICAL SAMPLE
    2.
    发明申请
    KIT AND METHOD FOR MEASURING MEASUREMENT TARGET SUBSTANCE IN BIOLOGICAL SAMPLE 审中-公开

    公开(公告)号：US20200033334A1

    公开(公告)日：2020-01-30

    申请号：US16585231

    申请日：2019-09-27

    Applicant: FUJIFILM Corporation

    Inventor： Hiroyuki CHIKU ,  Kousuke WATANABE ,  Kazuhei KANEKO ,  Kazuhiro HAMADA ,  Kouitsu SASAKI ,  Tomoaki YOSHIOKA ,  Naoyuki HANAKI

    IPC: G01N33/543 ,  G01N21/76 ,  C07F5/02 ,  C09K11/06

    Abstract: An object of the present invention is to provide a kit and a method capable of achieving high-precision measurement of a measurement target substance in a biological sample in a wide concentration range from a low concentration to a high concentration. According to the present invention, there is provided a kit for measuring a measurement target substance in a biological sample, the kit including: a labeled particle having a first binding substance capable of binding to the measurement target substance in a biological sample and having a first blocking agent; and a substrate having a second binding substance capable of binding to any one of the measurement target substance or the first binding substance and having a second blocking agent, in which the labeled particle is a luminescent labeled particle containing at least one kind of compound represented by Formula (1) and a particle, and the first blocking agent and the second blocking agent are different from each other. Each symbol in Formula (1) has the meaning described in the present specification.

    METHOD OF PRODUCING NUCLEIC ACID COMPOUND, AND NUCLEIC ACID COMPOUND
    4.
    发明申请
    METHOD OF PRODUCING NUCLEIC ACID COMPOUND, AND NUCLEIC ACID COMPOUND 有权

    公开(公告)号：US20220259255A1

    公开(公告)日：2022-08-18

    申请号：US17679104

    申请日：2022-02-24

    Applicant: FUJIFILM CORPORATION

    Inventor： Kazuhei KANEKO ,  Motomasa TAKAHASHI

    IPC: C07H21/02 ,  C07H1/00 ,  C07H19/073

    Abstract: There are provided a method of producing a nucleic acid compound, in which a nucleic acid compound in which any one of a 3-position or a 5-position of a ribose structure is protected by a structure represented by Formula (1), and the nucleic acid compound. In Formula (1), a ring A represents a condensed polycyclic aromatic hydrocarbon ring or an aromatic heterocyclic ring, YA's each independently represent —OCR2—, —NRCR2—, or —SCR2—, R's each independently represent a hydrogen atom, an alkyl group, an aromatic group, or an aromatic group-substituted alkyl group, k represents an integer of 1 to 5, RA's are each independently an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group, at least one aliphatic hydrocarbon group in k pieces of RA's has 12 or more carbon atoms, and the ring A may further have a substituent in addition to YA and RA.

    FLUORESCENT COMPOUND AND FLUORESCENT LABELED BIOLOGICAL SUBSTANCE USING THE SAME
    6.
    发明申请
    FLUORESCENT COMPOUND AND FLUORESCENT LABELED BIOLOGICAL SUBSTANCE USING THE SAME 有权

    公开(公告)号：US20210088526A1

    公开(公告)日：2021-03-25

    申请号：US17105638

    申请日：2020-11-27

    Applicant: FUJIFILM Corporation

    Inventor： Hiyoku NAKATA ,  Kousuke WATANABE ,  Akihiro ASAKURA ,  Keiko MAKITA ,  Yoshinori KANAZAWA ,  Kazuhei KANEKO

    IPC: G01N33/58 ,  C09K11/06 ,  C09B23/06 ,  G01N21/64

    Abstract: Provided are any one of the following fluorescent compounds and a fluorescent labeled biological substance having this fluorescent compound. X represents CR5 or N, and R1 to R7, Q1, Q2, L1, and L2 each represent a specific group.
    a ring β1 and a ring β2 are a 5- to 8-membered ring,
    At least one of R1 to R7, L1, L2, Q1, or Q2 has a specific hydrophilic group.
    However, in a case where the ring β1 and the ring β2 are a 6-membered ring, and L1 and L2 are an arylene group, R5 is not an aryl group substituted with a linear alkyl group having 18 or more carbon atoms. In addition to the regulation of the ring β1, the ring β2, L1, and L2, in a case where R5 has a substituent having a dipyrromethene boron complex structure, the dipyrromethene boron complex structure has a structure in which a dipyrromethene skeleton is coordinately bonded to a boron atom in the tridentate or tetradentate coordination.

    SOLID PHASE CARRIER AND KIT
    9.
    发明申请
    SOLID PHASE CARRIER AND KIT 有权

    公开(公告)号：US20210148900A1

    公开(公告)日：2021-05-20

    申请号：US17162124

    申请日：2021-01-29

    Applicant: FUJIFILM Corporation

    Inventor： Kazuhei KANEKO ,  Yoshinori KANAZAWA

    IPC: G01N33/546 ,  G01N33/543 ,  G01N33/58

    Abstract: An object of the present invention is to provide a solid phase carrier for carrying a bioactive substance, which achieves both the high non-specific adsorption inhibitory effect and high ligand binding amount. Another object of the present invention is to provide a kit for measuring a measurement target substance in a biosample, which includes the solid phase carrier. According to an embodiment of the present invention, a solid phase carrier for carrying a bioactive substance is provided which includes a copolymer present on a surface of the solid phase. The copolymer has a structural unit in which a hydrophilic group and a bioactive substance-reactive group are bonded to an acidic amino acid-derived group through a predetermined linking group.

    KIT, METHOD, AND REAGENT FOR MEASURING MEASUREMENT TARGET SUBSTANCE
    10.
    发明申请
    KIT, METHOD, AND REAGENT FOR MEASURING MEASUREMENT TARGET SUBSTANCE 审中-公开

    公开(公告)号：US20200025771A1

    公开(公告)日：2020-01-23

    申请号：US16585758

    申请日：2019-09-27

    Applicant: FUJIFILM Corporation

    Inventor： Hiroyuki CHIKU ,  Kousuke WATANABE ,  Kazuhei KANEKO ,  Kazuhiro HAMADA ,  Kouitsu SASAKI ,  Tomoaki YOSHIOKA ,  Naoyuki HANAKI

    IPC: G01N33/58 ,  C07D209/56

    Abstract: An object of the present invention is to provide a kit, a method, and a reagent which prevent the problem of false positive due to nonspecific adsorption, suppress the increase in noise to be generated, and are capable of achieving high-precision measurement of a measurement target substance in a wide concentration range from a low concentration to a high concentration. According to the present invention, there is provided a kit for measuring a measurement target substance, the kit including: a first particle having a label and modified with a first binding substance capable of specifically binding to a measurement target substance; a second particle having no label and modified with a second binding substance incapable of specifically binding to the measurement target substance; a flow channel for flowing the first particle and the second particle; and a substrate having a third binding substance capable of specifically binding to the measurement target substance or a substance capable of binding to the first binding substance, in which the first particle having a label is a luminescent labeled particle containing at least one kind of compound represented by Formula (1) and a particle. Each symbol in Formula (1) has the meaning described in the present specification.

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