公开(公告)号：US11905598B2

公开(公告)日：2024-02-20

申请号：US17902588

申请日：2022-09-02

Applicant: FUJIFILM Corporation

Inventor： Eijiro Iwase ,  Keio Okano ,  Katsuyuki Nukui

IPC: C23C18/44 ,  C23C18/16

CPC classification number: C23C18/44 ,  C23C18/166 ,  C23C18/1641

Abstract: An object is to coat a target position on a substrate with a dense film. In order to achieve the object, while a substrate on which a base containing a coating material is formed is transported, an auxiliary agent is applied to the substrate, and then a main agent containing a coating material is applied to the substrate to react the main agent with the auxiliary agent, so that a portion on the substrate where the base is formed is coated with the coating material.

公开(公告)号：US11452854B2

公开(公告)日：2022-09-27

申请号：US16391338

申请日：2019-04-23

Applicant: FUJIFILM Corporation

Inventor： Yoshiki Sakazaki ,  Ikuo Takano ,  Satoshi Wakamatsu ,  Keio Okano ,  Kenichiro Tamaki

IPC: A61M37/00 ,  B29C39/10 ,  B29C39/42 ,  B29C39/44 ,  B29K105/00 ,  B29L31/00

Abstract: Provided is a method of manufacturing a microneedle array in which an active ingredient is concentrated at a tip while an active ingredient content is guaranteed. In order to achieve the object, a method of manufacturing a microneedle array in which needle-like recessed portions of a mold are filled with a liquid to form one dose of a patch includes determining a filling amount of the liquid from a difference in mass of the mold before and after filling of the liquid, determining a filling state of the liquid in the mold filled with the liquid, sucking the mold in which the filling amount and the filling state of the liquid are determined to be normal from a rear face, and evaporating and drying a solvent of the liquid of the sucked mold.

公开(公告)号：US11135413B2

公开(公告)日：2021-10-05

申请号：US15695720

申请日：2017-09-05

Applicant: FUJIFILM Corporation

Inventor： Keio Okano ,  Satoshi Wakamatsu ,  Yoshinobu Katagiri

IPC: B29C39/02 ,  A61M37/00 ,  A61K9/00

Abstract: A method of producing a transdermal absorption sheet includes: filling needle-like recessed portions of a mold with a drug solution that is a polymer solution containing a drug; drying the drug solution filling the needle-like recessed portions to form a drug layer containing the drug; supplying a polymer layer forming solution to the mold, the mold provided with a step portion that has a height different from a height of a region in which the needle-like recessed portion is formed in a periphery of the region in which the needle-like recessed portion is formed in a range of equal to or greater than the step portion as seen from above, and then fixing a contact position of the polymer layer forming solution and the mold to the step portion while reducing the polymer layer forming solution; and drying the polymer layer forming solution to form a polymer layer.

公开(公告)号：US10512765B2

公开(公告)日：2019-12-24

申请号：US15335436

申请日：2016-10-27

Applicant: FUJIFILM Corporation

Inventor： Keio Okano ,  Yoshinobu Katagiri

IPC: A61M37/00 ,  B29C31/04 ,  B29C39/24 ,  B29C39/02 ,  A61K9/70 ,  B29C33/38 ,  B29C39/00 ,  B29K105/00 ,  B29L31/00

Abstract: The method includes the steps of: preparing a mold and a liquid filling device; and filling needle-like recessed portions with a liquid medicine by repeating the following: a filling operation in which the liquid medicine is supplied to the mold from the liquid filling device and the needle-like recessed portions are filled with the liquid medicine while a nozzle tip is brought into pressed contact with a surface of the mold; and a moving operation in which a nozzle is relatively moved with respect to the mold while the nozzle tip and the surface of the mold are in contact with each other, wherein the nozzle is held in a Z-axis drive unit configured to vertically move the nozzle while an elastic body is provided in the Z-axis drive unit, while the nozzle tip is brought into pressed contact with the surface of the mold.