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公开(公告)号：US11661622B2
公开(公告)日：2023-05-30
申请号：US16452553
申请日：2019-06-26
Applicant: FUJIFILM Corporation
Inventor： Hikaru Urano , Haruyasu Nakatsugawa , Tatsuya Ishizaka , Shinya Sugimoto , Isao Yonekubo
CPC classification number: C12Q1/52 , B01L3/52 , G01N1/38 , G01N33/491 , G01N2333/91188
Abstract: An object of the present invention is to provide a blood analysis method and a blood test kit, which are for performing quantitative analysis of components by precisely obtaining a dilution factor. According to the present invention, provided is a blood analysis method including a step of diluting a collected blood sample with a diluent solution; a step of determining a dilution factor by using a normal value of a normal component which is homeostatically present in blood; and a step of analyzing a concentration of a target component in the blood sample, in which the blood analysis method uses a member selected from the group consisting of a first storing instrument for storing a diluent solution, a separation instrument for separating and recovering blood plasma from the blood sample diluted with the diluent solution, a holding instrument for holding the separation instrument, a second storing instrument for storing the recovered blood plasma, and a sealing instrument for keeping the stored blood plasma within the second storing instrument, in which the diluent solution defines an amount of the normal component which is derived from the diluent solution and/or the members and may be contained in the diluent solution, and in which a volume of the blood sample is 50 μL or less, and a dilution factor of a blood plasma component in the blood sample is 14 times or more.
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公开(公告)号：US10697870B2
公开(公告)日：2020-06-30
申请号：US15861238
申请日：2018-01-03
Applicant: FUJIFILM Corporation
Inventor： Hikaru Urano , Tatsuya Ishizaka , Haruyasu Nakatsugawa , Susumu Osawa , Shinya Sugimoto
Abstract: An object is to provide a blood test kit and a blood analysis method capable of performing a blood test with a small amount of blood at high accuracy by visualizing a volume of blood collection and keeping the volume constant. Provided is a blood test kit for analyzing a concentration of a target component in a blood sample using a normal component homeostatically present in blood, the kit including: a blood collection instrument for collecting the blood sample; a diluent solution for diluting the collected blood sample; and a storing instrument for storing the diluted blood sample, in which the blood collection instrument is a capillary.
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公开(公告)号：US10739361B2
公开(公告)日：2020-08-11
申请号：US15861753
申请日：2018-01-04
Applicant: FUJIFILM Corporation
Inventor： Tatsuya Ishizaka , Haruyasu Nakatsugawa , Susumu Osawa , Shinya Sugimoto
Abstract: An object of the present invention is to provide a blood analysis method in which a high level of repeatability and reproducibility is achieved with respect to measurement values in a blood sample, and a blood test kit which is used for the blood analysis method. According to the present invention, a blood analysis method including a step of diluting a collected blood sample with a diluent solution; a step of quantitatively determining sodium ions in the diluent solution of the blood sample by using a solution containing β-galactosidase and at least one substrate which is convertible by β-galactosidase so as to determine a dilution factor from a normal value of serum and blood plasm sodium ions which are homeostatically present in the blood and the quantitative value of sodium ions; and a step of analyzing a concentration of a target component to be measured in the blood sample from the determined dilution factor and a measurement value of a concentration of the target component to be measured in the blood sample, in which the diluent solution is a diluent solution which does not contain sodium ions, is provided.
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