公开(公告)号：US11241690B2

公开(公告)日：2022-02-08

申请号：US16391336

申请日：2019-04-23

Applicant: FUJIFILM Corporation

Inventor： Osamu Noguchi ,  Shinya Sugimoto

IPC: B01L3/00

Abstract: Provided are a fiber rod, a blood collection instrument, and a blood test kit, which are capable of easily taking out a blood specimen.
A fiber rod which is used in a blood collection instrument in a blood test kit, including a fiber portion which is composed of a first fiber and a second fiber having different fiber diameters and which has a void volume within a range of 90% to 97%, in which a distance between surfaces facing each other of the fiber portion includes a region within a range of 1 mm to 1.6 mm.

公开(公告)号：US20150171313A1

公开(公告)日：2015-06-18

申请号：US14628609

申请日：2015-02-23

Applicant: FUJIFILM Corporation

Inventor： Paul A. Hoisington ,  Jeffrey Birkmeyer ,  Andreas Bibl ,  Mats G. Ottosson ,  Gregory De Brabander ,  Zhenfang Chen ,  Mark Nepomnishy ,  Shinya Sugimoto

IPC: H01L41/332 ,  B41J2/16 ,  H01L41/316

CPC classification number: H01L41/332 ,  B41J2/14233 ,  B41J2/1607 ,  B41J2/161 ,  B41J2/1626 ,  B41J2/1628 ,  B41J2/1629 ,  B41J2/1631 ,  B41J2/1632 ,  B41J2/1642 ,  B41J2/1646 ,  B41J2002/14241 ,  H01L41/098 ,  H01L41/22 ,  H01L41/316 ,  H01L41/33

Abstract: Processes for forming an actuator having a curved piezoelectric membrane are disclosed. The processes utilize a profile-transferring substrate having a curved surface surrounded by a planar surface to form the curved piezoelectric membrane. The piezoelectric material used for the piezoelectric actuator is deposited on at least the curved surface of the profile-transferring substrate before the profile-transferring substrate is removed from the underside of the curved piezoelectric membrane. The resulting curved piezoelectric membrane includes grain structures that are columnar and aligned, and all or substantially all of the columnar grains are locally perpendicular to the curved surface of the piezoelectric membrane.

Abstract translation: 公开了一种用于形成具有弯曲压电膜的致动器的工艺。 该工艺利用具有由平面表面包围的弯曲表面的轮廓转印衬底以形成弯曲的压电膜。 用于压电致动器的压电材料沉积在轮廓转移衬底的至少曲面上，然后从曲面压电膜的下侧移除轮廓转移衬底。 所形成的弯曲压电膜包括柱状和对准的晶粒结构，并且所有或基本上所有的柱状晶粒局部垂直于压电膜的弯曲表面。

公开(公告)号：US11661622B2

公开(公告)日：2023-05-30

申请号：US16452553

申请日：2019-06-26

Applicant: FUJIFILM Corporation

Inventor： Hikaru Urano ,  Haruyasu Nakatsugawa ,  Tatsuya Ishizaka ,  Shinya Sugimoto ,  Isao Yonekubo

IPC: G01N1/38 ,  C12Q1/52 ,  B01L3/00 ,  G01N33/49 ,  G01N33/48

CPC classification number: C12Q1/52 ,  B01L3/52 ,  G01N1/38 ,  G01N33/491 ,  G01N2333/91188

Abstract: An object of the present invention is to provide a blood analysis method and a blood test kit, which are for performing quantitative analysis of components by precisely obtaining a dilution factor. According to the present invention, provided is a blood analysis method including a step of diluting a collected blood sample with a diluent solution; a step of determining a dilution factor by using a normal value of a normal component which is homeostatically present in blood; and a step of analyzing a concentration of a target component in the blood sample, in which the blood analysis method uses a member selected from the group consisting of a first storing instrument for storing a diluent solution, a separation instrument for separating and recovering blood plasma from the blood sample diluted with the diluent solution, a holding instrument for holding the separation instrument, a second storing instrument for storing the recovered blood plasma, and a sealing instrument for keeping the stored blood plasma within the second storing instrument, in which the diluent solution defines an amount of the normal component which is derived from the diluent solution and/or the members and may be contained in the diluent solution, and in which a volume of the blood sample is 50 μL or less, and a dilution factor of a blood plasma component in the blood sample is 14 times or more.

公开(公告)号：US11442070B2

公开(公告)日：2022-09-13

申请号：US16454064

申请日：2019-06-27

Applicant: FUJIFILM Corporation

Inventor： Kota Fukui ,  Shinya Sugimoto ,  Isao Yonekubo

IPC: G01N33/72 ,  G01N1/38 ,  G01N33/49 ,  G01N33/48 ,  G01N33/96

Abstract: An object of the present invention is to provide a blood analysis method and a blood test kit, which are capable of performing measurement of a plurality of target components to be analyzed with high accuracies in a case where hemolysis occurs in a case of measuring an amount of target components to be analyzed in a small volume of a blood sample. According to the present invention, provided is a blood analysis method for measuring a concentration of a target component to be analyzed, the blood analysis method including: a step of diluting a collected blood sample with a diluent solution, a step of determining a dilution factor by using a normal value of a normal component which is homeostatically present in blood, a step of analyzing the concentration of the target component to be analyzed in the blood sample, measuring an amount of hemolysis in the blood sample, correcting the dilution factor according to the measured amount of hemolysis, and analyzing the concentration of the target component to be analyzed using the corrected dilution factor.

公开(公告)号：US11166659B2

公开(公告)日：2021-11-09

申请号：US16454062

申请日：2019-06-27

Applicant: FUJIFILM Corporation

Inventor： Hikaru Urano ,  Shinya Sugimoto ,  Isao Yonekubo

IPC: B01L3/00 ,  G01N1/10 ,  A61B5/15 ,  G01N1/38 ,  G01N33/49 ,  A61B5/00

Abstract: An object of the present invention is to provide a blood test kit and a blood analysis method, which are for performing quantitative analysis of components by precisely obtaining a dilution factor. According to the present invention, provided is a blood test kit for analyzing a concentration of a target component in a blood sample using a normal component which is homeostatically present in blood, the kit including a diluent solution for diluting the blood sample, a first storing instrument for storing the diluent solution, a separation instrument for separating and recovering blood plasma from the blood sample diluted with the diluent solution, a holding instrument for holding the separation instrument, a second storing instrument for storing the recovered blood plasma, and a sealing instrument for keeping the stored blood plasma within the second storing instrument, in which the separation instrument is composed of glass fiber coated with a resin.

公开(公告)号：US10823745B2

公开(公告)日：2020-11-03

申请号：US15862700

申请日：2018-01-05

Applicant: FUJIFILM Corporation

Inventor： Seiji Yamashita ,  Haruyasu Nakatsugawa ,  Susumu Osawa ,  Shinya Sugimoto

IPC: A61B5/15 ,  B01L3/00 ,  G01N33/96 ,  G01N33/48 ,  G01N33/49 ,  G01N1/38

Abstract: An object of the present invention is to provide a blood test kit and a blood analysis method capable of performing a blood test with a small amount of blood at high accuracy by visualizing a volume of blood collection and keeping the volume constant. According to the present invention, a blood test kit including a diluent solution for diluting components of a blood sample; and at least one transparent container for storing the components of the blood sample and the diluent solution, in which at least one constituent component included in the blood test kit is marked with a graduation for measuring the components of the blood sample and a liquid volume of the diluent solution, is provided.

公开(公告)号：US10697870B2

公开(公告)日：2020-06-30

申请号：US15861238

申请日：2018-01-03

Applicant: FUJIFILM Corporation

Inventor： Hikaru Urano ,  Tatsuya Ishizaka ,  Haruyasu Nakatsugawa ,  Susumu Osawa ,  Shinya Sugimoto

IPC: A61B5/15 ,  B01L3/00 ,  G01N1/38 ,  G01N1/10 ,  G01N33/96 ,  G01N33/48 ,  G01N33/49

Abstract: An object is to provide a blood test kit and a blood analysis method capable of performing a blood test with a small amount of blood at high accuracy by visualizing a volume of blood collection and keeping the volume constant. Provided is a blood test kit for analyzing a concentration of a target component in a blood sample using a normal component homeostatically present in blood, the kit including: a blood collection instrument for collecting the blood sample; a diluent solution for diluting the collected blood sample; and a storing instrument for storing the diluted blood sample, in which the blood collection instrument is a capillary.

公开(公告)号：US11179081B2

公开(公告)日：2021-11-23

申请号：US16452555

申请日：2019-06-26

Applicant: FUJIFILM Corporation

Inventor： Hikaru Urano ,  Haruyasu Nakatsugawa ,  Shinya Sugimoto ,  Isao Yonekubo

IPC: G01N33/96 ,  A61B5/15 ,  G01N1/38 ,  G01N33/49 ,  B01L3/00 ,  G01N1/12

Abstract: An object of the present invention is to provide a blood analysis method and a blood test kit, which are for performing quantitative analysis of components by precisely obtaining a dilution factor. According to the present invention, provided is a blood analysis method including: a step of diluting a collected blood sample with a diluent solution; a step of determining a dilution factor by using a normal value of a normal component which is homeostatically present in blood; and a step of analyzing a concentration of a target component in the blood sample, in which the blood analysis method uses a member selected from the group consisting of a first storing instrument for storing the diluent solution, a collection instrument for collecting the blood, a separation instrument for separating and recovering blood plasma from the blood sample diluted with the diluent solution, a holding instrument for holding the separation instrument, and a second storing instrument for storing the recovered blood plasma, and in which the dilution factor is corrected after calculating in advance an amount of the normal component derived from the diluent solution, and/or an amount of the normal component derived from at least one of the members which may be contained in the diluent solution.

公开(公告)号：US10788478B2

公开(公告)日：2020-09-29

申请号：US15861875

申请日：2018-01-04

Applicant: FUJIFILM Corporation

Inventor： Hikaru Urano ,  Haruyasu Nakatsugawa ,  Susumu Osawa ,  Shinya Sugimoto

IPC: G01N33/49 ,  A61B5/15 ,  G01N1/10 ,  G01N33/96 ,  G01N33/48 ,  B01L3/00 ,  G01N1/38 ,  G01N33/66

Abstract: An object is to perform analysis of a target component contained in a small volume of blood sample at high accuracy using a normal component homeostatically present in blood. Provided is a blood test kit for analyzing a concentration of a target component in a blood sample by using a normal component homeostatically present in blood, the kit including: a diluent solution for diluting a blood sample; and a member selected from the group consisting of a first storing instrument in which the diluent solution is stored, a separating instrument for separating and recovering blood plasma from the blood sample diluted with the diluent solution, a holding instrument for holding the separating instrument, a second storing instrument for storing the recovered blood plasma, and a sealing instrument for keeping the stored blood plasma in the second storing instrument, in which an amount of the normal component which is derived from the member and may be contained in the diluent solution is defined.

公开(公告)号：US10746723B2

公开(公告)日：2020-08-18

申请号：US15861353

申请日：2018-01-03

Applicant: FUJIFILM Corporation

Inventor： Seiji Yamashita ,  Haruyasu Nakatsugawa ,  Susumu Osawa ,  Shinya Sugimoto

IPC: G01N33/48 ,  A61B5/15 ,  G01N33/487 ,  G01N1/28 ,  G01N33/49 ,  G01N1/00 ,  G01N1/38 ,  G01N33/66 ,  G01N33/96 ,  G01N1/10

Abstract: An object of the present invention is to provide a blood test kit of which a component in a small volume of blood can be mailed in a safe state by controlling the influence of the outside temperature during the mailing, and a highly accurate blood analysis method in which coefficient of variation of a measurement value is reduced. According to the present invention, a blood test kit including a diluent solution for diluting a blood sample; a separating means for recovering blood plasma components from the diluted blood sample; a container for storing the blood plasma components recovered from the diluted blood sample; and a cold insulation means for cold-insulating the container, is provided.