公开(公告)号：US10898116B2

公开(公告)日：2021-01-26

申请号：US14208344

申请日：2014-03-13

申请人： Flexible Medical Systems LLC

发明人： Joseph J Vidalis ,  Joseph A Marcanio ,  John Frederick Currie ,  Helena Woodvine Snyder ,  Vikas Bhatia

IPC分类号： A61B5/15 ,  A61B5/1486 ,  A61B5/145 ,  A61B5/157 ,  A61B5/151

摘要： Methods and systems for manufacturing a transdermal sampling and analysis device for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples are provided. A method of manufacturing the device may improve performance and includes forming channel structures on the lid of the device, thereby making the spacer/channel support structures physically independent and separable from the sensing electrode. Other methods of manufacturing the device may improve performance and include forming at least one of the electrodes on each of the base and the lid, and forming a recessed second spacer layer over the channel support structures, thereby separating the channel support structures and the electrode on the lid to allow a larger area of the electrode to be exposed to the biological sample.

公开(公告)号：US09968284B2

公开(公告)日：2018-05-15

申请号：US13688954

申请日：2012-11-29

申请人： Flexible Medical Systems, LLC

发明人： Joseph J Vidalis ,  Joseph A Marcanio ,  John Frederick Currie ,  Sundar Nadarajan ,  Helena Woodvine

IPC分类号： A61B5/05 ,  A61B5/145 ,  A61B5/1477 ,  A61B5/1486 ,  A61B5/1491 ,  A61B5/151 ,  A61B5/15 ,  A61B5/155 ,  A61B5/157

CPC分类号： A61B5/14514 ,  A61B5/14532 ,  A61B5/1477 ,  A61B5/1486 ,  A61B5/1491 ,  A61B5/150022 ,  A61B5/150969 ,  A61B5/15134 ,  A61B5/155 ,  A61B5/157

摘要： A system and methods are provided for reducing electrochemical interference in a transdermal sampling and analysis device. A one-step transdermal glucose biosensor may calculate glucose concentrations that are artificially high compared to traditional home blood glucose sensors due to interference, which may be mitigated by forming an anti-interferent barrier layer over a sensing element. The anti-interferent barrier layer may be formed over a sensing layer and may possess a charge type which repels interferent molecules having the same charge type from interacting with the sensing layer disposed below the anti-interferent barrier layer.

公开(公告)号：US20140275895A1

公开(公告)日：2014-09-18

申请号：US14208344

申请日：2014-03-13

申请人： Flexible Medical Systems LLC

发明人： Joseph J. Vidalis ,  Joseph A. Marcanio ,  John Frederick Currie ,  Helena Woodvine Snyder ,  Vikas Bhatia

IPC分类号： A61B5/15 ,  A61B5/145 ,  A61B5/157 ,  A61B5/1486

CPC分类号： A61B5/150076 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150274 ,  A61B5/150862 ,  A61B5/15134 ,  A61B5/157

摘要： Methods and systems for manufacturing a transdermal sampling and analysis device for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples are provided. A method of manufacturing the device may improve performance and includes forming channel structures on the lid of the device, thereby making the spacer/channel support structures physically independent and separable from the sensing electrode. Other methods of manufacturing the device may improve performance and include forming at least one of the electrodes on each of the base and the lid, and forming a recessed second spacer layer over the channel support structures, thereby separating the channel support structures and the electrode on the lid to allow a larger area of the electrode to be exposed to the biological sample.

摘要翻译： 提供了用于非侵入地和经皮获得来自受试者的生物样品的透皮取样和分析装置的制造方法和系统，并确定所获得的生物样品的分析物的水平。 制造该装置的方法可以提高性能，并且包括在装置的盖上形成通道结构，从而使间隔物/通道支撑结构在物理上是独立的并且与感测电极分离。 制造该器件的其它方法可改善性能，并且包括在基底和盖子的每一个上形成电极中的至少一个，以及在通道支撑结构上方形成凹陷的第二间隔层，从而将通道支撑结构和电极分开 盖子允许电极的较大面积暴露于生物样品。