公开(公告)号：US10898116B2

公开(公告)日：2021-01-26

申请号：US14208344

申请日：2014-03-13

申请人： Flexible Medical Systems LLC

发明人： Joseph J Vidalis ,  Joseph A Marcanio ,  John Frederick Currie ,  Helena Woodvine Snyder ,  Vikas Bhatia

IPC分类号： A61B5/15 ,  A61B5/1486 ,  A61B5/145 ,  A61B5/157 ,  A61B5/151

摘要： Methods and systems for manufacturing a transdermal sampling and analysis device for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples are provided. A method of manufacturing the device may improve performance and includes forming channel structures on the lid of the device, thereby making the spacer/channel support structures physically independent and separable from the sensing electrode. Other methods of manufacturing the device may improve performance and include forming at least one of the electrodes on each of the base and the lid, and forming a recessed second spacer layer over the channel support structures, thereby separating the channel support structures and the electrode on the lid to allow a larger area of the electrode to be exposed to the biological sample.

公开(公告)号：US09968284B2

公开(公告)日：2018-05-15

申请号：US13688954

申请日：2012-11-29

申请人： Flexible Medical Systems, LLC

发明人： Joseph J Vidalis ,  Joseph A Marcanio ,  John Frederick Currie ,  Sundar Nadarajan ,  Helena Woodvine

IPC分类号： A61B5/05 ,  A61B5/145 ,  A61B5/1477 ,  A61B5/1486 ,  A61B5/1491 ,  A61B5/151 ,  A61B5/15 ,  A61B5/155 ,  A61B5/157

CPC分类号： A61B5/14514 ,  A61B5/14532 ,  A61B5/1477 ,  A61B5/1486 ,  A61B5/1491 ,  A61B5/150022 ,  A61B5/150969 ,  A61B5/15134 ,  A61B5/155 ,  A61B5/157

摘要： A system and methods are provided for reducing electrochemical interference in a transdermal sampling and analysis device. A one-step transdermal glucose biosensor may calculate glucose concentrations that are artificially high compared to traditional home blood glucose sensors due to interference, which may be mitigated by forming an anti-interferent barrier layer over a sensing element. The anti-interferent barrier layer may be formed over a sensing layer and may possess a charge type which repels interferent molecules having the same charge type from interacting with the sensing layer disposed below the anti-interferent barrier layer.