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    Novel Medicaments
    3.
    发明申请
    Novel Medicaments 失效
    新药

    公开(公告)号：US20090312309A1

    公开(公告)日：2009-12-17

    申请号：US11917823

    申请日：2006-06-30

    申请人： Rolf Hohlweg ,  Knud Erik Andersen ,  Jan Lindy Sorensen ,  Jane Marie Lundbeck

    发明人： Rolf Hohlweg ,  Knud Erik Andersen ,  Jan Lindy Sorensen ,  Jane Marie Lundbeck

    IPC分类号： A61K31/5513 ,  A61K31/5377 ,  A61K31/501 ,  A61K31/497 ,  C07D413/14 ,  C07D403/04

    CPC分类号： C07D213/74 ,  C07D213/84 ,  C07D213/87 ,  C07D237/20 ,  C07D403/04 ,  C07D403/12 ,  C07D417/10

    摘要： Novel compounds which interact with the histamine H3 receptor are defined. These compounds are particularly useful in the treatment of a variety of diseases or conditions in which histamine H3 interactions are beneficial. Thus, the compounds may find use, e.g., in the treatment of diseases of the central nervous system, the peripheral nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinological system. The novel compounds have a core consisting of a 6 membered aromatic ring containing at least one nitrogen atom and two carbon atoms in the ring and, at the remaining positions in the ring, there is either a carbon or a nitrogen atom.

    摘要翻译： 定义与组胺H3受体相互作用的新型化合物。 这些化合物特别可用于治疗组胺H3相互作用有益的各种疾病或病症。 因此，该化合物可用于例如治疗中枢神经系统，周围神经系统，心血管系统，肺系统，胃肠系统和内分泌系统的疾病。 该新化合物具有由在环中含有至少一个氮原子和两个碳原子的6元芳香环组成的核心，并且在该环的其余位置上有碳原子或氮原子。

    Medicaments
    4.
    发明授权
    Medicaments 有权
    药剂

    公开(公告)号：US08846677B2

    公开(公告)日：2014-09-30

    申请号：US13472090

    申请日：2012-05-15

    申请人： Rolf Hohlweg ,  Knud Erik Andersen ,  Jan Lindy Sorensen ,  Jane Marie Lundbeck

    发明人： Rolf Hohlweg ,  Knud Erik Andersen ,  Jan Lindy Sorensen ,  Jane Marie Lundbeck

    IPC分类号： A61K31/501 ,  C07D401/00 ,  C07D409/00

    CPC分类号： C07D213/74 ,  C07D213/84 ,  C07D213/87 ,  C07D237/20 ,  C07D403/04 ,  C07D403/12 ,  C07D417/10

    摘要： Novel compounds which interact with the histamine H3 receptor are defined. These compounds are particularly useful in the treatment of a variety of diseases or conditions in which histamine H3 interactions are beneficial. Thus, the compounds may find use, e.g., in the treatment of diseases of the central nervous system, the peripheral nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinological system. The novel compounds have a core consisting of a 6 membered aromatic ring containing at least one nitrogen atom and two carbon atoms in the ring and, at the remaining positions in the ring, there is either a carbon or a nitrogen atom.

    摘要翻译： 定义与组胺H3受体相互作用的新型化合物。 这些化合物特别可用于治疗组胺H3相互作用有益的各种疾病或病症。 因此，该化合物可用于例如治疗中枢神经系统，周围神经系统，心血管系统，肺系统，胃肠系统和内分泌系统的疾病。 该新化合物具有由在环中含有至少一个氮原子和两个碳原子的6元芳香环组成的核心，并且在该环的其余位置上有碳原子或氮原子。

    Medicaments
    5.
    发明授权
    Medicaments 失效
    药剂

    公开(公告)号：US08501739B2

    公开(公告)日：2013-08-06

    申请号：US11917823

    申请日：2006-06-30

    申请人： Rolf Hohlweg ,  Knud Erik Andersen ,  Jan Lindy Sorensen ,  Jane Marie Lundbeck

    发明人： Rolf Hohlweg ,  Knud Erik Andersen ,  Jan Lindy Sorensen ,  Jane Marie Lundbeck

    IPC分类号： A61K31/50 ,  C07D401/00

    CPC分类号： C07D213/74 ,  C07D213/84 ,  C07D213/87 ,  C07D237/20 ,  C07D403/04 ,  C07D403/12 ,  C07D417/10

    摘要： Novel compounds which interact with the histamine H3 receptor are defined. These compounds are particularly useful in the treatment of a variety of diseases or conditions in which histamine H3 interactions are beneficial. Thus, the compounds may find use, e.g., in the treatment of diseases of the central nervous system, the peripheral nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinological system. The novel compounds have a core consisting of a 6 membered aromatic ring containing at least one nitrogen atom and two carbon atoms in the ring and, at the remaining positions in the ring, there is either a carbon or a nitrogen atom.

    摘要翻译： 定义与组胺H3受体相互作用的新型化合物。 这些化合物特别可用于治疗组胺H3相互作用有益的各种疾病或病症。 因此，该化合物可用于例如治疗中枢神经系统，周围神经系统，心血管系统，肺系统，胃肠系统和内分泌系统的疾病。 该新化合物具有由在环中含有至少一个氮原子和两个碳原子的6元芳香环组成的核心，并且在该环的其余位置上有碳原子或氮原子。

    Novel Medicaments
    6.
    发明申请
    Novel Medicaments 有权
    新药

    公开(公告)号：US20120232078A1

    公开(公告)日：2012-09-13

    申请号：US13472090

    申请日：2012-05-15

    申请人： Rolf Hohlweg ,  Knud Erik Andersen ,  Jan Lindy Sorensen ,  Jane Marie Lundbeck

    发明人： Rolf Hohlweg ,  Knud Erik Andersen ,  Jan Lindy Sorensen ,  Jane Marie Lundbeck

    IPC分类号： A61K31/506 ,  A61P3/04 ,  A61P25/24 ,  A61K31/5377

    CPC分类号： C07D213/74 ,  C07D213/84 ,  C07D213/87 ,  C07D237/20 ,  C07D403/04 ,  C07D403/12 ,  C07D417/10

    摘要： Novel compounds which interact with the histamine H3 receptor are defined. These compounds are particularly useful in the treatment of a variety of diseases or conditions in which histamine H3 interactions are beneficial. Thus, the compounds may find use, e.g., in the treatment of diseases of the central nervous system, the peripheral nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinological system. The novel compounds have a core consisting of a 6 membered aromatic ring containing at least one nitrogen atom and two carbon atoms in the ring and, at the remaining positions in the ring, there is either a carbon or a nitrogen atom.

    摘要翻译： 定义与组胺H3受体相互作用的新型化合物。 这些化合物特别可用于治疗组胺H3相互作用有益的各种疾病或病症。 因此，该化合物可用于例如治疗中枢神经系统，周围神经系统，心血管系统，肺系统，胃肠系统和内分泌系统的疾病。 该新化合物具有由在环中含有至少一个氮原子和两个碳原子的6元芳香环组成的核心，并且在该环的其余位置上有碳原子或氮原子。

    Substituted imidazoles, their preparation and use
    8.
    发明授权
    Substituted imidazoles, their preparation and use 失效
    取代的咪唑，其制备和用途

    公开(公告)号：US06417218B1

    公开(公告)日：2002-07-09

    申请号：US09484621

    申请日：2000-01-18

    申请人： Florencio Zaragoza Dorwald ,  Knud Erik Andersen

    发明人： Florencio Zaragoza Dorwald ,  Knud Erik Andersen

    IPC分类号： A61K31415

    CPC分类号： C07D233/56 ,  C07D233/64 ,  C07D403/08 ,  C07D417/12

    摘要： A class of substituted imidazole compounds of formula I methods for their preparation, pharmaceutical compositions comprising them and use thereof in the treatment of disorders related to the histamine H3 receptor are disclosed. More particularly, these compounds possess histamine H3 receptor antagonistic activity and are thus useful for the treatment of disorders in which a histamine H3 receptor blockade is beneficial.

    摘要翻译： 公开了一类取代的咪唑化合物，其制备方法，其制备方法，包含它们的药物组合物及其用于治疗与组胺H3受体有关的病症的用途。 更具体地说，这些化合物具有组胺H3受体拮抗活性，因此可用于治疗组胺H3受体阻断有益的病症。