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公开(公告)号：US20050084485A1
公开(公告)日：2005-04-21
申请号：US10687523
申请日：2003-10-15
申请人： Florian Lang , Siegfried Waldegger , Philipp Lang , Angelika Lampert , Hannsjoerg Seybert , Nikola Jeck
发明人： Florian Lang , Siegfried Waldegger , Philipp Lang , Angelika Lampert , Hannsjoerg Seybert , Nikola Jeck
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to a method for diagnosing hypertension, and/or allergy, and/or hair loss, and/or liabilty for infection, of a human being, or a predisposition therefor; to a nucleic acid molecule coding for a human ClCKb protein comprising a genetic alteration at amino acid position 481 compared to the wild type, as well as for corresponding segments thereof; to a nucleic acid molecule which binds to the before-mentioned nucleic acid molecule under stringent conditions, as well as to a nucleic acid molecule which binds to that nucleic acid molecule; to a (poly)peptide encoded by the afore-mentioned nucleic acid molecules; to a method for identifying substances modulating activity of a peptide derived from ClCKb protein that is genetically altered at amino acid position 481 compared to the wild type; to a substance for modulating activity of a peptide derived from ClCKb protein that is genetically altered at amino acid position 481 compared to the wild type; to methods for preparing a pharmaceutical composition for treatment of hypertension, and/or allergy, and/or hair loss, and/or liability for infection; to pharmaceutical compositions; and to a method for treating a human being affected by hypertension, and/or allergy and/or hair loss, and/or liability for infection.
摘要翻译： 本发明涉及一种用于诊断人类或其易感性的高血压，/或过敏和/或脱发，和/或感染的可能性的方法; 涉及编码人类ClCKb蛋白质的核酸分子，其包含与野生型相比在氨基酸位置481处的遗传改变，以及其对应的片段; 涉及在严格条件下与前述核酸分子结合的核酸分子，以及与该核酸分子结合的核酸分子; 涉及由上述核酸分子编码的（多）肽; 涉及一种用于鉴定与野生型相比在氨基酸位置481遗传改变的来自ClCKb蛋白的肽调节活性的物质的方法; 涉及调节与野生型相比在氨基酸位置481遗传改变的来自ClCKb蛋白的肽的活性的物质; 制备用于治疗高血压和/或过敏和/或脱发的药物组合物和/或感染责任的方法; 至药物组合物; 以及治疗受高血压，/或过敏和/或脱发影响的人的方法和/或感染责任。
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公开(公告)号：US06326181B1
公开(公告)日：2001-12-04
申请号：US09031295
申请日：1998-02-26
申请人： Florian Lang , Siegfried Waldegger
发明人： Florian Lang , Siegfried Waldegger
IPC分类号： C12N912
CPC分类号： C12N9/1205 , A61K38/00
摘要： The present invention relates to the cloning and characterization of a human serine/threonine kinase (h-sgk: serum and glucocorticoid dependent kinase). The invention furthermore relates to reagents for diagnosing conditions associated with a change in cell volume and/or in “macromolecular crowding” in the body, such as, for example, hypernatremia, hyponatremia, diabetes mellitus, renal failure, hypercatabolism, hepatic encephalopathy, inflammation and microbial or viral infections. The present invention additionally relates to pharmaceuticals comprising the h-sgk, nucleic acids which code for the h-sgk, or receptors, in particular antibodies, which specifically bind to the h-sgk.
摘要翻译： 本发明涉及人丝氨酸/苏氨酸激酶（h-sgk：血清和糖皮质激素依赖性激酶）的克隆和表征。 本发明还涉及用于诊断与细胞体积变化和/或体内“大分子拥挤”相关的病症的试剂，例如高钠血症，低钠血症，糖尿病，肾功能衰竭，高分泌症，肝性脑病，炎症 和微生物或病毒感染。 本发明还涉及包含h-sgk，编码h-sgk的核酸或特异性结合h-sgk的受体，特别是抗体的药物。
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公开(公告)号：US07235364B2
公开(公告)日：2007-06-26
申请号：US11398208
申请日：2006-04-04
申请人： Florian Lang , Siegfried Waldegger , Philipp Lang , Angelika Lampert , Hannsjoerg Seybert , Nikola Jeck
发明人： Florian Lang , Siegfried Waldegger , Philipp Lang , Angelika Lampert , Hannsjoerg Seybert , Nikola Jeck
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to a method for diagnosing hypertension, and/or allergy, and/or hair loss, and/or liabilty for infection, of a human being, or a predisposition therefor; to a nucleic acid molecule coding for a human ClCKb protein comprising a genetic alteration at amino acid position 481 compared to the wild type, as well as for corresponding segments thereof; to a nucleic acid molecule which binds to the before-mentioned nucleic acid molecule under stringent conditions, as well as to a nucleic acid molecule which binds to that nucleic acid molecule; to a (poly)peptide encoded by the afore-mentioned nucleic acid molecules; to a method for identifying substances modulating activity of a peptide derived from ClCKb protein that is genetically altered at amino acid position 481 compared to the wild type; to a substance for modulating activity of a peptide derived from ClCKb protein that is genetically altered at amino acid position 481 compared to the wild type; to methods for preparing a pharmaceutical composition for treatment of hypertension, and/or allergy, and/or hair loss, and/or liability for infection; to pharmaceutical compositions; and to a method for treating a human being affected by hypertension, and/or allergy and/or hair loss, and/or liability for infection.
摘要翻译： 本发明涉及一种用于诊断人类或其易感性的高血压，/或过敏和/或脱发，和/或感染的可能性的方法; 涉及编码人类ClCKb蛋白质的核酸分子，其包含与野生型相比在氨基酸位置481处的遗传改变，以及其对应的片段; 涉及在严格条件下与前述核酸分子结合的核酸分子，以及与该核酸分子结合的核酸分子; 涉及由上述核酸分子编码的（多）肽; 涉及一种用于鉴定与野生型相比在氨基酸位置481遗传改变的来自ClCKb蛋白的肽调节活性的物质的方法; 涉及调节与野生型相比在氨基酸位置481遗传改变的来自ClCKb蛋白的肽的活性的物质; 制备用于治疗高血压和/或过敏和/或脱发的药物组合物和/或感染责任的方法; 至药物组合物; 以及治疗受高血压，/或过敏和/或脱发影响的人的方法和/或感染责任。
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4.发明申请Medicaments comprising inhibitors of the cell volume-regulated human kinase h-sgk 审中-公开包含细胞体积调节人激酶h-sgk的抑制剂的药物公开(公告)号：US20050064501A1
公开(公告)日：2005-03-24
申请号：US10984945
申请日：2004-11-10
IPC分类号： A61K31/00 , A61K31/4741 , A61K31/553 , A61K38/00 , C12Q1/68
CPC分类号： A61K31/4741 , A61K31/00 , A61K31/553 , A61K38/005
摘要： The present invention relates to medicaments comprising inhibitors or activators of the cell volume-regulated human kinase h-sgk. Such medicaments are suitable for the therapy of pathological states in which an increased or reduced expression of h-sgk is found.
摘要翻译： 本发明涉及包含细胞体积调节人激酶h-sgk的抑制剂或活化剂的药物。 这种药物适用于治疗h-sgk表达增加或减少的病理状态。
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公开(公告)号：US06855520B2
公开(公告)日：2005-02-15
申请号：US10000039
申请日：2001-12-04
申请人： Florian Lang , Siegfried Waldegger
发明人： Florian Lang , Siegfried Waldegger
IPC分类号： G01N33/573 , A61K31/70 , A61K38/00 , A61K39/395 , A61P13/02 , A61P15/00 , C07K14/705 , C12N9/12 , C12N15/02 , C12N15/54 , C12P21/08 , C12Q1/68 , G01N33/577 , C12P19/30 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： C12N9/1205 , A61K38/00
摘要： The present invention relates to the cloning and characterization of a human serine/threonine kinase (h-sgk: serum and glucocorticoid dependent kinase). The invention furthermore relates to reagents for diagnosing conditions associated with a change in cell volume and/or in “macromolecular crowding” in the body, such as, for example, hypernatremia, hyponatremia, diabetes mellitus, renal failure, hypercatabolism, hepatic encephalopathy, inflammation and microbial or viral infections. The present invention additionally relates to pharmaceuticals comprising the h-sgk, nucleic acids which code for the h-sgk, or receptors, in particular antibodies, which specifically bind to the h-sgk.
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公开(公告)号：US20060240459A1
公开(公告)日：2006-10-26
申请号：US11398208
申请日：2006-04-04
申请人： Florian Lang , Siegfried Waldegger , Philipp Lang , Angelika Lampert , Hannsjoerg Seybert , Nikola Jeck
发明人： Florian Lang , Siegfried Waldegger , Philipp Lang , Angelika Lampert , Hannsjoerg Seybert , Nikola Jeck
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to a method for diagnosing hypertension, and/or allergy, and/or hair loss, and/or liabilty for infection, of a human being, or a predisposition therefor; to a nucleic acid molecule coding for a human ClCKb protein comprising a genetic alteration at amino acid position 481 compared to the wild type, as well as for corresponding segments thereof; to a nucleic acid molecule which binds to the before-mentioned nucleic acid molecule under stringent conditions, as well as to a nucleic acid molecule which binds to that nucleic acid molecule; to a (poly)peptide encoded by the afore-mentioned nucleic acid molecules; to a method for identifying substances modulating activity of a peptide derived from ClCKb protein that is genetically altered at amino acid position 481 compared to the wild type; to a substance for modulating activity of a peptide derived from ClCKb protein that is genetically altered at amino acid position 481 compared to the wild type; to methods for preparing a pharmaceutical composition for treatment of hypertension, and/or allergy, and/or hair loss, and/or liability for infection; to pharmaceutical compositions; and to a method for treating a human being affected by hypertension, and/or allergy and/or hair loss, and/or liability for infection.
摘要翻译： 本发明涉及一种用于诊断人类或其易感性的高血压，/或过敏和/或脱发，和/或感染的可能性的方法; 涉及编码人类ClCKb蛋白质的核酸分子，其包含与野生型相比在氨基酸位置481处的遗传改变，以及其对应的片段; 涉及在严格条件下与前述核酸分子结合的核酸分子，以及与该核酸分子结合的核酸分子; 涉及由上述核酸分子编码的（多）肽; 涉及一种用于鉴定与野生型相比在氨基酸位置481遗传改变的来自ClCKb蛋白的肽调节活性的物质的方法; 涉及调节与野生型相比在氨基酸位置481遗传改变的来自ClCKb蛋白的肽的活性的物质; 制备用于治疗高血压和/或过敏和/或脱发的药物组合物和/或感染责任的方法; 至药物组合物; 以及治疗受高血压，/或过敏和/或脱发影响的人的方法和/或感染责任。
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公开(公告)号：US07074573B2
公开(公告)日：2006-07-11
申请号：US10687523
申请日：2003-10-15
申请人： Florian Lang , Siegfried Waldegger , Phillipp Lang , Angelika Lampert , Hannsjoerg Seybert , Nikola Jeck
发明人： Florian Lang , Siegfried Waldegger , Phillipp Lang , Angelika Lampert , Hannsjoerg Seybert , Nikola Jeck
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to a method for diagnosing hypertension, and/or allergy, and/or hair loss, and/or liability for infection, of a human being, or a predisposition therefor; to a nucleic acid molecule coding for a human ClCKb protein comprising a genetic alteration at amino acid position 481 compared to the wild type, as well as for corresponding segments thereof; to a nucleic acid molecule which binds to the before-mentioned nucleic acid molecule under stringent conditions, as well as to a nucleic acid molecule which binds to that nucleic acid molecule; to a (poly)peptide encoded by the afore-mentioned nucleic acid molecules; to a method for identifying substances modulating activity of a peptide derived from ClCKb protein that is genetically altered at amino acid position 481 compared to the wild type; to a substance for modulating activity of a peptide derived from ClCKb protein that is genetically altered at amino acid position 481 compared to the wild type; to methods for preparing a pharmaceutical composition for treatment of hypertension, and/or allergy, and/or hair loss, and/or liability for infection; to pharmaceutical compositions; and to a method for treating a human being affected by hypertension, and/or allergy and/or hair loss, and/or liability for infection.
摘要翻译： 本发明涉及一种用于诊断人类或其易感性的高血压，/或过敏和/或脱发，和/或感染责任的方法; 涉及编码人类ClCKb蛋白质的核酸分子，其包含与野生型相比在氨基酸位置481处的遗传改变，以及其对应的片段; 涉及在严格条件下与前述核酸分子结合的核酸分子，以及与该核酸分子结合的核酸分子; 涉及由上述核酸分子编码的（多）肽; 涉及一种用于鉴定与野生型相比在氨基酸位置481遗传改变的来自ClCKb蛋白的肽调节活性的物质的方法; 涉及调节与野生型相比在氨基酸位置481遗传改变的来自ClCKb蛋白的肽的活性的物质; 制备用于治疗高血压和/或过敏和/或脱发的药物组合物和/或感染责任的方法; 至药物组合物; 以及治疗受高血压，/或过敏和/或脱发影响的人的方法和/或感染责任。
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公开(公告)号：US20050181402A1
公开(公告)日：2005-08-18
申请号：US11044570
申请日：2005-01-28
申请人： Florian Lang , Siegfried Waldegger
发明人： Florian Lang , Siegfried Waldegger
IPC分类号： G01N33/573 , A61K31/70 , A61K38/00 , A61K39/395 , A61P13/02 , A61P15/00 , C07K14/705 , C12N9/12 , C12N15/02 , C12N15/54 , C12P21/08 , C12Q1/68 , G01N33/577 , C07H21/04 , C07K16/40 , G01N33/53 , G01N33/567
CPC分类号： C12N9/1205 , A61K38/00
摘要： The present invention relates to the cloning and characterization of a human serine/threonine kinase (h-sgk: serum and glucocorticoid dependent kinase). The invention furthermore relates to reagents for diagnosing conditions associated with a change in cell volume and/or in “macromolecular crowding” in the body, such as, for example, hypernatremia, hyponatremia, diabetes. mellitus, renal failure, hypercatabolism, hepatic encephalopathy, inflammation and microbial or viral infections. The present invention additionally relates to pharmaceuticals comprising the h-sgk, nucleic acids which code for the h-sgk, or receptors, in particular antibodies, which specifically bind to the h-sgk.
摘要翻译： 本发明涉及人丝氨酸/苏氨酸激酶（h-sgk：血清和糖皮质激素依赖性激酶）的克隆和表征。 本发明还涉及用于诊断与细胞体积变化和/或体内“大分子拥挤”相关的病症的试剂，例如高钠血症，低钠血症，糖尿病。 肾功能衰竭，高分泌症，肝性脑病，炎症和微生物或病毒感染。 本发明还涉及包含h-sgk，编码h-sgk的核酸或特异性结合h-sgk的受体，特别是抗体的药物。
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公开(公告)号：US20120149765A1
公开(公告)日：2012-06-14
申请号：US13315850
申请日：2011-12-09
申请人： Florian Lang
发明人： Florian Lang
IPC分类号： A61K31/7088 , C12Q1/68 , C07K16/40 , A61K31/473 , A61P9/12 , G01N33/566 , A61K31/553
CPC分类号： C12Q1/485
摘要： The invention relates to the utilization of a substance for diagnostic determination of sgk1 (serum and glucocorticoid dependent kinase 1) and to the utilization of an active agent in order to influence sgk1 for therapeutic treatment of diseases associated with disordered activity of the tissue factor and to a diagnostic kit related to such substances or such active agents.
摘要翻译： 本发明涉及用于sgk1（血清和糖皮质激素依赖性激酶1）的诊断测定的物质的利用和活性剂的利用，以影响sgk1用于治疗与组织因子的无序活性相关的疾病的治疗，以及 与这些物质或这种活性剂相关的诊断试剂盒。
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公开(公告)号：US20110224302A1
公开(公告)日：2011-09-15
申请号：US13131233
申请日：2009-11-02
申请人： Thomas Fuchss , Ulrich Graedler , Norbert Beier , Rolf Gericke , Florian Lang
发明人： Thomas Fuchss , Ulrich Graedler , Norbert Beier , Rolf Gericke , Florian Lang
IPC分类号： A61K31/166 , C07C243/18 , A61P3/10 , A61P3/04 , A61P3/00 , A61P9/00 , A61P13/12 , A61P35/00 , A61P27/12 , A61P31/04 , A61P31/00 , A61P25/28 , A61P17/02 , A61P29/00 , A61P1/00
CPC分类号： C07C243/38 , A61K31/15 , A61K45/06 , A61K2300/00
摘要： Novel difluorophenyldiacylhydrazide derivatives of the formula I, in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in claim 1, are kinase inhibitors and can be used for the treatment of diseases and complaints such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and kidney diseases, generally in any type of fibroses, inflammatory processes, tumours and tumour diseases
摘要翻译： 式Ⅰ的新型二氟苯基二酰肼衍生物，其中R1，R2，R3，R4，R5，R6和R7具有权利要求1所述的含义，是激酶抑制剂，可用于治疗诸如糖尿病，肥胖症 ，代谢综合征（血脂异常），全身和肺性高血压，心血管疾病和肾脏疾病，通常在任何类型的纤维，炎症过程，肿瘤和肿瘤疾病
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