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公开(公告)号：US09636368B2
公开(公告)日：2017-05-02
申请号：US14823585
申请日：2015-08-11
发明人： Siao-Jhen Chen , Yen-Lin Chen , Hsun-Yin Hsu , Shy-Yunn Wann , Mei-Huei Chen , Li-Wen Yu
IPC分类号： A61K35/747 , C12P1/04 , C12N1/20 , C12R1/225 , C12N9/02 , A23L2/38 , A23L33/135 , A61K9/19 , C12N1/02 , A61K9/00 , A23L2/52
CPC分类号： A61K35/747 , A23L2/382 , A23L2/52 , A23L33/135 , A23V2002/00 , A23Y2220/73 , A61K9/0053 , A61K9/0095 , A61K9/19 , A61K35/745 , A61K36/064 , C12N1/02 , C12N1/20 , C12N9/0093 , C12N2500/72 , C12P1/04 , C12R1/225 , C12Y117/03002
摘要： A method for inhibiting xanthine oxidase and for reducing uric acid levels using a composition obtained by culturing Lactobacillus rhamnosus in a medium. Also disclosed is a composition including a metabolite of Lactobacillus rhamnosus for reducing uric acid levels in a subject and a method for producing the composition.
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2.发明申请NOVEL STRAIN OF LACTOBACILLUS RHAMNOSUS AND ITS METABOLITES FOR USE IN INHIBITING XANTHINE OXIDASE AND TREATING GOUT 有权乳酸杆菌RHAMNOSUS的新型菌株及其代谢物用于抑制Xanthine氧化酶和处理GOUT公开(公告)号：US20160051602A1
公开(公告)日：2016-02-25
申请号：US14823585
申请日：2015-08-11
发明人： Siao-Jhen Chen , Yen-Lin Chen , Hsun-Yin Hsu , Shy-Yunn Wann , Mei-Huei Chen , Li-Wen Yu
IPC分类号： A61K35/747 , A61K9/00 , C12P1/04 , A61K9/19
CPC分类号： A61K35/747 , A23L2/382 , A23L2/52 , A23L33/135 , A23V2002/00 , A23Y2220/73 , A61K9/0053 , A61K9/0095 , A61K9/19 , A61K35/745 , A61K36/064 , C12N1/02 , C12N1/20 , C12N9/0093 , C12N2500/72 , C12P1/04 , C12R1/225 , C12Y117/03002
摘要： A method for inhibiting xanthine oxidase and for reducing uric acid levels using a composition obtained by culturing Lactobacillus rhamnosus in a medium. Also disclosed is a composition including a metabolite of Lactobacillus rhamnosus for reducing uric acid levels in a subject and a method for producing the composition.
摘要翻译： 使用通过在培养基中培养鼠李糖乳杆菌获得的组合物来抑制黄嘌呤氧化酶和降低尿酸水平的方法。 还公开了包含用于降低受试者的尿酸水平的鼠李糖乳杆菌的代谢物的组合物和该组合物的制造方法。
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3.发明申请公开(公告)号：US20170216376A1
公开(公告)日：2017-08-03
申请号：US15483575
申请日：2017-04-10
发明人： Siao-Jhen Chen , Yen-Lin Chen , Hsun-Yin Hsu , Shy-Yunn Wann , Mei-Huei Chen , Li-Wen Yu
IPC分类号： A61K35/747 , A23L33/135 , A61K35/745 , A61K36/064 , A61K9/19 , A61K9/00
CPC分类号： A61K35/747 , A23L2/382 , A23L2/52 , A23L33/135 , A23V2002/00 , A23Y2220/73 , A61K9/0053 , A61K9/0095 , A61K9/19 , A61K35/745 , A61K36/064 , C12N1/02 , C12N1/20 , C12N9/0093 , C12N2500/72 , C12P1/04 , C12R1/225 , C12Y117/03002
摘要： A method for inhibiting xanthine oxidase and for reducing uric acid levels using a composition obtained by culturing Lactobacillus rhamnosus in a medium. Also disclosed is a composition including a metabolite of Lactobacillus rhamnosus for reducing uric acid levels in a subject and a method for producing the composition.
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公开(公告)号：US20170165239A1
公开(公告)日：2017-06-15
申请号：US15370527
申请日：2016-12-06
发明人： Ming-Der Wu , Ming-Jen Cheng , Yen-Lin Chen , Siao-Jhen Chen , Li-Wen Yu , Hsun-Yin Hsu
IPC分类号： A61K31/437 , C12Q1/26 , A61K9/00
CPC分类号： A61K31/437 , A61K9/0053 , C12Q1/26 , C12Y117/03002 , G01N2333/9029
摘要： A method for inhibiting xanthine oxidase and for reducing uric acid levels using a beta-carboline alkaloid compound of formula (I), wherein R1 is selected from the group consisting of a carboxyl group, a carboxylate group, a carboxamide group and hydrogen, and R2 is selected from the group consisting of —CH2COOCH3, a methoxy group, hydrogen and a methyl group. Also disclosed is a method for monitoring xanthine oxidase inhibiting activity level.
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