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    Accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing
    1.
    发明授权
    Accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing 有权
    加速单核苷酸多态性的鉴定和基因组测序中克隆的比对

    公开(公告)号：US06534293B1

    公开(公告)日：2003-03-18

    申请号：US09478189

    申请日：2000-01-05

    申请人： Francis Barany ,  Jianzhao Liu ,  Brian W. Kirk ,  Monib Zirvi ,  Norman P. Gerry ,  Philip B. Paty

    发明人： Francis Barany ,  Jianzhao Liu ,  Brian W. Kirk ,  Monib Zirvi ,  Norman P. Gerry ,  Philip B. Paty

    IPC分类号： C12P1934

    CPC分类号： C12Q1/6827 ,  C12Q1/6837 ,  C12Q1/6841 ,  C12Q1/6855 ,  C12Q1/6874 ,  Y10T436/143333 ,  C12Q2525/155 ,  C12Q2521/301 ,  C12Q2539/107 ,  C12Q2535/113 ,  C12Q2525/191 ,  C12Q2565/501 ,  C12Q2561/125 ,  C12Q2565/514

    摘要： The present invention is directed to a method of assembling genomic maps of an organism's DNA or portions thereof. A library of an organism's DNA is provided where the individual genomic segments or sequences are found on more than one clone in the library. Representations of the genome are created, and nucleic acid sequence information is generated from the representations. The sequence information is analyzed to determine clone overlap from a representation. The clone overlap and sequence information from different representations is combined to assemble a genomic map of the organism. Once the genomic map is obtained, genomic sequence information from multiple individuals can be applied to the map and compared with one another to identify single nucleotide polymorphisms. These single nucleotide polymorphisms can be detected, and alleles quantified, by conducting (1) a global PCR amplification which creates a genome representation, and (2) a ligation detection reaction process whose ligation products are captured by hybridization to a support.

    摘要翻译： 本发明涉及一种组装生物体DNA或其部分的基因组图谱的方法。 提供了生物体DNA的文库，其中在文库中的多于一个克隆上发现各个基因组片段或序列。 创建基因组的表示，并从表示生成核酸序列信息。 分析序列信息以从表示确定克隆重叠。 来自不同表示的克隆重叠和序列信息被组合以组装生物体的基因组图。 一旦得到基因组图谱，可以将多个个体的基因组序列信息应用于该图并相互比较以鉴定单核苷酸多态性。 通过进行（1）产生基因组表达的全局PCR扩增，以及（2）通过与载体杂交捕获其连接产物的连接检测反应过程，可以检测这些单核苷酸多态性和等位基因进行定量。

    SULFUR-CONTAINING MACROMOLECULES AND METHODS FOR THEIR PREPARATION
    3.
    发明申请
    SULFUR-CONTAINING MACROMOLECULES AND METHODS FOR THEIR PREPARATION 有权
    含硫的大分子及其制备方法

    公开(公告)号：US20120148958A1

    公开(公告)日：2012-06-14

    申请号：US13391186

    申请日：2010-08-06

    申请人： Benzhong Tang ,  Ka wai Jim ,  Anjun Qin ,  Wing Yip Lam ,  Jianzhao Liu

    发明人： Benzhong Tang ,  Ka wai Jim ,  Anjun Qin ,  Wing Yip Lam ,  Jianzhao Liu

    IPC分类号： C08F128/04 ,  G03F7/20

    CPC分类号： C08G75/025 ,  C08G75/045

    摘要： A sulfur-containing macromolecule and a method of preparing the sulfur-containing macromolecule comprising a polymerization step are provided, where the sulfur-containing macromolecule contains internal units of formula (I) and the polymerization step is formula (II) wherein n is greater than 1, said precursor comprises alkyne having one or more acetylene groups and thiol having one or more thiol groups; and R is remainder of said thiol excluding said thiol groups, R′ is remainder of said alkyne excluding said acetylene groups, and R and R′ are selected from organic or organometallic groups.

    摘要翻译： 提供含硫高分子和制备包含聚合步骤的含硫高分子的方法，其中含硫高分子含有式（I）的内部单元，聚合步骤为式（II），其中n大于 1，所述前体包括具有一个或多个乙炔基的炔烃和具有一个或多个硫醇基团的硫醇; 并且R是除所述硫醇基之外的所述硫醇的剩余部分，R'是除所述乙炔基之外的所述炔烃的剩余部分，R和R'选自有机或有机金属基团。

    Sulfur-containing macromolecules and methods for their preparation
    4.
    发明授权
    Sulfur-containing macromolecules and methods for their preparation 有权
    含硫大分子及其制备方法

    公开(公告)号：US08859698B2

    公开(公告)日：2014-10-14

    申请号：US13391186

    申请日：2010-08-06

    申请人： Benzhong Tang ,  Ka Wai Jim ,  Anjun Qin ,  Wing Yip Lam ,  Jianzhao Liu

    发明人： Benzhong Tang ,  Ka Wai Jim ,  Anjun Qin ,  Wing Yip Lam ,  Jianzhao Liu

    IPC分类号： C08G12/30 ,  C08G75/04

    CPC分类号： C08G75/025 ,  C08G75/045

    摘要： A sulfur-containing macromolecule and a method of preparing the sulfur-containing macromolecule comprising a polymerization step are provided, where the sulfur-containing macromolecule contains internal units of formula (I) and the polymerization step is formula (II) wherein n is greater than 1, said precursor comprises alkyne having one or more acetylene groups and thiol having one or more thiol groups; and R is remainder of said thiol excluding said thiol groups, R′ is remainder of said alkyne excluding said acetylene groups, and R and R′ are selected from organic or organometallic groups.

    摘要翻译： 提供含硫高分子和制备包含聚合步骤的含硫高分子的方法，其中含硫高分子含有式（I）的内部单元，聚合步骤为式（II），其中n大于 1，所述前体包括具有一个或多个乙炔基的炔烃和具有一个或多个硫醇基团的硫醇; 并且R是除所述硫醇基之外的所述硫醇的剩余部分，R'是除所述乙炔基之外的所述炔烃的剩余部分，R和R'选自有机或有机金属基团。