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公开(公告)号：US20120295874A1
公开(公告)日：2012-11-22
申请号：US13500857
申请日：2010-10-07
申请人： Francis Barany , Maneesh Pingle , Sarah Filippa Giardina , Donald Bergstrom , Lee Daniel Arnold
发明人： Francis Barany , Maneesh Pingle , Sarah Filippa Giardina , Donald Bergstrom , Lee Daniel Arnold
IPC分类号： A61K31/69 , G01N33/566 , A61K31/397 , A61K31/506 , A61K31/505 , A61K31/454 , A61K31/415 , A61K31/357 , C07F5/02 , C07D403/14 , C07D239/42 , C07D401/12 , C07D231/38 , C07D207/24 , C07D205/04 , C07D319/12 , C07D413/14 , A61K31/4015 , G01N33/53
CPC分类号： C07D319/14 , C07D207/12 , C07D207/24 , C07D209/52 , C07D239/42 , C07D239/54 , C07D241/36 , C07D263/20 , C07D295/18 , C07D307/80 , C07D317/10 , C07D317/44 , C07D319/12 , C07D403/06 , C07D403/14 , C07D405/14 , C07D413/06 , C07D471/14 , C07D491/04 , C07D491/10 , C07D491/14 , C07F5/025 , C40B30/04
摘要： The present invention is directed to a monomer useful in preparing therapeutic compounds. The monomer includes one or more pharmacophores which potentially binds to a target molecule with a dissociation constant of less than 300 μM and a linker element connected to the pharmacophore. The linker element has a molecular weight less than 500 daltons, is connected, directly or indirectly through a connector, to the pharmacophore.
摘要翻译： 本发明涉及可用于制备治疗化合物的单体。 单体包括一个或多个药效团，其可以以小于300μM的解离常数潜在地结合靶分子，并连接到药效团。 连接体元件具有小于500道尔顿的分子量，通过连接器直接或间接连接到药效团。
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公开(公告)号：US09771345B2
公开(公告)日：2017-09-26
申请号：US13500857
申请日：2010-10-07
申请人： Francis Barany , Maneesh Pingle , Sarah Filippa Giardina , Donald Bergstrom , Lee Daniel Arnold
发明人： Francis Barany , Maneesh Pingle , Sarah Filippa Giardina , Donald Bergstrom , Lee Daniel Arnold
IPC分类号： A61K31/69 , C07D319/14 , C07D207/12 , C07D207/24 , C07D209/52 , C07D239/42 , C07D239/54 , C07D241/36 , C07D263/20 , C07D295/18 , C07D307/80 , C07D317/10 , C07D317/44 , C07D319/12 , C07D403/06 , C07D403/14 , C07D405/14 , C07D413/06 , C07D471/14 , C07D491/04 , C07D491/10 , C07D491/14 , C07F5/02 , C40B30/04
CPC分类号： C07D319/14 , C07D207/12 , C07D207/24 , C07D209/52 , C07D239/42 , C07D239/54 , C07D241/36 , C07D263/20 , C07D295/18 , C07D307/80 , C07D317/10 , C07D317/44 , C07D319/12 , C07D403/06 , C07D403/14 , C07D405/14 , C07D413/06 , C07D471/14 , C07D491/04 , C07D491/10 , C07D491/14 , C07F5/025 , C40B30/04
摘要： The present invention is directed to a monomer useful in preparing therapeutic compounds. The monomer includes one or more pharmacophores which potentially binds to a target molecule with a dissociation constant of less than 300 μM and a linker element connected to the pharmacophore. The linker element has a molecular weight less than 500 daltons, is connected, directly or indirectly through a connector, to the pharmacophore.
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公开(公告)号：US20110263688A1
公开(公告)日：2011-10-27
申请号：US12937053
申请日：2009-04-09
IPC分类号： A61K31/7052 , A61P35/00 , C40B40/04 , C07H21/00 , C40B30/04
CPC分类号： A61K47/545 , A61K31/69 , C07D233/64 , C07D307/92 , C07D309/30 , C07D319/24 , C07D493/22 , C07F5/02 , C07H7/02 , C07H9/02 , C40B30/04
摘要： A monomer useful in prepaπng therapeutic compounds includes a diversity element which potentially binds to a target molecule with a dissociation constant of less than 300 11 M and a linker element connected to the diversity element The linker element has a molecular weight less than 500 daltons, is connected, directly or indirectly through a connector, to said diversity element, and is capable of forming a reversible covalent bond or noncovalent interaction with a binding partner of the linker element The monomers can be covalently or non-covalently linked together to form a therapeutic multimer or a precursor thereof
摘要翻译： 可用于制备治疗化合物的单体包括潜在地结合靶分子的多样性元件，其解离常数小于300±11M，连接元件连接到多样性元件。连接体元件具有小于500道尔顿的分子量 通过连接器直接或间接连接到所述多样性元件，并且能够与连接体元件的结合配偶体形成可逆共价键或非共价相互作用。所述单体可以共价或非共价连接在一起形成 治疗性多聚体或其前体
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公开(公告)号：US08853185B2
公开(公告)日：2014-10-07
申请号：US12937053
申请日：2009-04-09
CPC分类号： A61K47/545 , A61K31/69 , C07D233/64 , C07D307/92 , C07D309/30 , C07D319/24 , C07D493/22 , C07F5/02 , C07H7/02 , C07H9/02 , C40B30/04
摘要： A monomer useful in prepaπng therapeutic compounds includes a diversity element which potentially binds to a target molecule with a dissociation constant of less than 300 11 M and a linker element connected to the diversity element The linker element has a molecular weight less than 500 daltons, is connected, directly or indirectly through a connector, to said diversity element, and is capable of forming a reversible covalent bond or noncovalent interaction with a binding partner of the linker element The monomers can be covalently or non-covalently linked together to form a therapeutic multimer or a precursor thereof.
摘要翻译： 可用于制备治疗化合物的单体包括潜在地结合靶分子的多样性元件，其解离常数小于300±11M，连接元件连接到多样性元件。连接体元件具有小于500道尔顿的分子量 通过连接器直接或间接连接到所述多样性元件，并且能够与连接体元件的结合配偶体形成可逆共价键或非共价相互作用。所述单体可以共价或非共价连接在一起形成 治疗性多聚体或其前体。
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