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公开(公告)号:US5981601A
公开(公告)日:1999-11-09
申请号:US343559
申请日:1995-03-20
IPC分类号: C12Q1/02 , A61K31/12 , A61K31/122 , A61K31/375 , A61K31/505 , A61K31/525 , A61K31/70 , A61K45/00 , A61P31/12 , A61P43/00 , C07C50/02 , C07C50/06 , C07C50/28 , C12N9/02 , C12Q1/26 , G01N33/50
CPC分类号: G01N33/5088 , A61K31/12 , A61K31/375 , A61K31/70 , C07C50/02 , C07C50/06 , C07C50/28 , G01N33/5014
摘要: The present invention relates generally to therapeutic compositions comprising one or more redox compounds. The therapeutic compositions of the present invention are useful in enhancing cellular ATP production thereby ameliorating the effects of reduced bioenergy capacity such as occurring during aging, systemic or vascular disease or in conjunction with chemical therapy. The present invention therefore contemplates a method for enhancing cellular ATP production in an animal, said method comprising administering to said animal, an effective amount of a redox compound for a time and under conditions sufficient to increase or otherwise elevate the activity and/or operation of a cellular oxidoreductase system in cells of said animal.
摘要翻译: PCT No.PCT / AU93 / 00251 Sec。 371日期1995年3月20日 102(e)日期1995年3月20日PCT提交1993年5月28日PCT公布。 第WO93 / 24650号公报 日期1993年12月9日本发明一般涉及包含一种或多种氧化还原化合物的治疗组合物。 本发明的治疗组合物可用于增强细胞ATP生成,从而改善生物能量能力降低的作用,例如在老化,全身或血管疾病期间发生或与化学疗法相结合。 因此,本发明考虑了用于增强动物中的细胞ATP产生的方法,所述方法包括在足以增加或以其他方式提高活性和/或操作的条件下向所述动物施用有效量的氧化还原化合物 所述动物的细胞中的细胞氧化还原酶系统。
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公开(公告)号:USD284854S
公开(公告)日:1986-07-29
申请号:US517416
申请日:1983-07-26
申请人: Francois Vaillant
设计人: Francois Vaillant
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公开(公告)号:US20080038230A1
公开(公告)日:2008-02-14
申请号:US11596397
申请日:2005-05-12
CPC分类号: G01N33/5073 , C12N5/0631 , C12N2501/01 , C12N2501/11 , C12N2501/33 , C12N2501/39
摘要: The present invention relates generally to a method for the generation of a substantially homogenous population of undifferentiated cells. More particularly, the present invention relates to a method for isolating a substantially homogenous population of stem cells, and in particular, mammary stem cells (MaSCs). The MaSCs of the present invention are isolated on the basis of differential levels of proteins present on their cell surface. The MaSCs of the present invention are particularly useful as targets for identifying agents which modulate MaSC survival, self-renewal, proliferation and/or differentiation in both normal and diseased tissue such as, but not limited to, tumor tissue, and, also as source of tissue for the regeneration, replacement and/or augmentation of tissue damaged and/or lost after disease or injury.
摘要翻译: 本发明一般涉及产生基本均匀的未分化细胞群的方法。 更具体地说,本发明涉及用于分离基本均匀的干细胞群,特别是乳腺干细胞(MaSCs)的方法。 基于存在于其细胞表面上的蛋白质的差异水平分离本发明的MaSC。 本发明的MaSCs特别可用作鉴定调节正常组织和患病组织中MaSC存活,自我更新,增殖和/或分化的药剂的靶标,所述组织例如但不限于肿瘤组织,以及作为来源 的组织用于在疾病或损伤后损伤和/或丢失的组织的再生,置换和/或增加。
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公开(公告)号:US08741635B2
公开(公告)日:2014-06-03
申请号:US11596397
申请日:2005-05-12
IPC分类号: C12N5/00
CPC分类号: G01N33/5073 , C12N5/0631 , C12N2501/01 , C12N2501/11 , C12N2501/33 , C12N2501/39
摘要: The present invention relates generally to a method for the generation of a substantially homogenous population of undifferentiated cells. More particularly, the present invention relates to a method for isolating a substantially homogenous population of stem cells, and in particular, mammary stem cells (MaSCs). The MaSCs of the present invention are isolated on the basis of differential levels of proteins present on their cell surface. The MaSCs of the present invention are particularly useful as targets for identifying agents which modulate MaSC survival, self-renewal, proliferation and/or differentiation in both normal and diseased tissue such as, but not limited to, tumor tissue, and, also as source of tissue for the regeneration, replacement and/or augmentation of tissue damaged and/or lost after disease or injury.
摘要翻译: 本发明一般涉及产生基本均匀的未分化细胞群的方法。 更具体地说,本发明涉及用于分离基本均匀的干细胞群,特别是乳腺干细胞(MaSCs)的方法。 基于存在于其细胞表面上的蛋白质的差异水平分离本发明的MaSC。 本发明的MaSCs特别可用作鉴定调节正常组织和患病组织中MaSC存活,自我更新,增殖和/或分化的药剂的靶标,所述组织例如但不限于肿瘤组织,以及作为来源 的组织用于在疾病或损伤后损伤和/或丢失的组织的再生,置换和/或增加。
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公开(公告)号:US4719562A
公开(公告)日:1988-01-12
申请号:US631986
申请日:1984-07-18
IPC分类号: G06F15/167 , G06F13/00 , G06F15/16
CPC分类号: G06F15/167
摘要: The system according to the invention comprises a central microprocessor and peripheral microprocessors. A direct-access transfer memory is provided for the communication of the processors with one another. The memory is divided into as many distinct, determined zones as there are peripheral processors. The memory is connected to two addressing buses of which the latter serves equally well to address the boxes of the memory by the central microprocessor and to address the zones of the memory allocated to the peripheral microprocessors. The system is particularly well adapted to data transfers between a telephone automatic switch and subscribers' sets.
摘要翻译: 根据本发明的系统包括中央微处理器和外围微处理器。 提供了一种用于处理器彼此通信的直接访问转移存储器。 存储器被分成与外围处理器一样多的不同的,确定的区域。 存储器连接到两个寻址总线,其后者同样适用于中央微处理器对存储器的盒进行寻址,并且对分配给外围微处理器的存储器的区域进行寻址。 该系统特别适用于电话自动切换和用户组之间的数据传输。
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