公开(公告)号：US20060031023A1

公开(公告)日：2006-02-09

申请号：US11246325

申请日：2005-10-06

申请人： Frank Aguilera ,  Denis Faubert ,  Marguerite Boulos ,  John Tsang ,  Michael Hu ,  Joachim Ostermann ,  Paul Kearney ,  Pierre Thibault

发明人： Frank Aguilera ,  Denis Faubert ,  Marguerite Boulos ,  John Tsang ,  Michael Hu ,  Joachim Ostermann ,  Paul Kearney ,  Pierre Thibault

IPC分类号： G06F19/00 ,  G01N33/48 ,  G01N33/50

CPC分类号： G01N33/6848 ,  Y10T436/24

摘要： The present invention is directed to computer automated methods and systems for identifying and characterizing biomolecules in a biological sample. Mass spectrometry measurements are obtained on biomolecules in a sample. These measurements are analyzed to determine the abundance of the biomolecules in the sample, and the abundance measurements are coupled with one or more distinguishing characteristics of biomolecules they are associated with, thereby permitting computer-mediated comparison of abundances of biomolecules from multiple biological samples.

公开(公告)号：US20060269944A1

公开(公告)日：2006-11-30

申请号：US11429113

申请日：2006-05-04

申请人： Frank Aguilera ,  Denis Faubert ,  Marguerite Boulos ,  John Tsang ,  Michael Hu ,  Joachim Ostermann ,  Paul Kearney ,  Pierre Thibault

发明人： Frank Aguilera ,  Denis Faubert ,  Marguerite Boulos ,  John Tsang ,  Michael Hu ,  Joachim Ostermann ,  Paul Kearney ,  Pierre Thibault

IPC分类号： C12Q1/68 ,  G06F19/00 ,  G01N33/48

CPC分类号： G01N33/6848 ,  Y10T436/24

摘要： The present invention is directed to computer automated methods and systems for identifying and characterizing biomolecules in a biological sample. Mass spectrometry measurements are obtained on biomolecules in a sample. These measurements are analyzed to determine the abundance of the biomolecules in the sample, and the abundance measurements are coupled with one or more distinguishing characteristics of biomolecules they are associated with, thereby permitting computer-mediated comparison of abundances of biomolecules from multiple biological samples.

摘要翻译： 本发明涉及用于识别和表征生物样品中生物分子的计算机自动化方法和系统。 在样品中的生物分子上获得质谱测量。 分析这些测量以确定样品中生物分子的丰度，并且丰度测量与其相关联的生物分子的一个或多个区别特征相结合，从而允许计算机介导的来自多个生物样品的生物分子丰度的比较。

公开(公告)号：US20060003385A1

公开(公告)日：2006-01-05

申请号：US11188954

申请日：2005-07-25

申请人： Frank Aguilera ,  Denis Faubert ,  Marguerite Boulos ,  John Tsang ,  Michael Hu ,  Joachim Ostermann ,  Paul Kearney ,  Pierre Thibault

发明人： Frank Aguilera ,  Denis Faubert ,  Marguerite Boulos ,  John Tsang ,  Michael Hu ,  Joachim Ostermann ,  Paul Kearney ,  Pierre Thibault

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G06F19/00

CPC分类号： G01N33/6848 ,  Y10T436/24

摘要： The present invention is directed to computer automated methods and systems for identifying and characterizing biomolecules in a biological sample. Mass spectrometry measurements are obtained on biomolecules in a sample. These measurements are analyzed to determine the abundance of the biomolecules in the sample, and the abundance measurements are coupled with one or more distinguishing characteristics of biomolecules they are associated with, thereby permitting computer-mediated comparison of abundances of biomolecules from multiple biological samples.

公开(公告)号：US20070106065A1

公开(公告)日：2007-05-10

申请号：US11344933

申请日：2006-01-31

申请人： Paul Kearney ,  Heather Butler ,  Navdeep Jaitly ,  Sajani Swamy ,  Lyes Hamaidi ,  Marcelo Filgueira ,  Pierre Thibault ,  Denis Faubert ,  Daniel Chelsky ,  Joel Lanoix ,  Sylvain Brunet ,  Kevin Eng ,  Frank Aguilera ,  John Tsang ,  Michael Hu ,  Joachim Ostermann ,  Marguerite Boulos

发明人： Paul Kearney ,  Heather Butler ,  Navdeep Jaitly ,  Sajani Swamy ,  Lyes Hamaidi ,  Marcelo Filgueira ,  Pierre Thibault ,  Denis Faubert ,  Daniel Chelsky ,  Joel Lanoix ,  Sylvain Brunet ,  Kevin Eng ,  Frank Aguilera ,  John Tsang ,  Michael Hu ,  Joachim Ostermann ,  Marguerite Boulos

IPC分类号： C07K14/82 ,  C07K16/30 ,  C12P21/06 ,  A61K39/395 ,  A61K39/00 ,  C12P21/08 ,  C12P21/04

CPC分类号： C07K14/82 ,  C07K14/4748 ,  C07K16/3046

摘要： Surprisingly, the present inventors have discovered that expression of TAT-001 protein in human patients is associated with cancer, and that the overexpressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-001 is associated with abnormal development and growth, and may be useful as a target for the identification of anti-cancer compounds, including antibodies for use in immunotherapy. Accordingly, the present invention provides methods for the identification of compounds that inhibit TAT-001 expression or activity, comprising: contacting a candidate compound with a TAT-001 and detecting the presence or absence of binding between said compound and said TAT-001, or detecting a change in TAT-001 expression or activity. Methods are also included for the identification of anti-cancer compounds and compounds that modulate TAT-001 expression or activity, comprising: administering a compound to a cell or cell population, and detecting a change in TAT-001 expression or activity.

摘要翻译： 令人惊奇的是，本发明人已经发现，人类患者中TAT-001蛋白的表达与癌症有关，并且过表达的蛋白质存在于质膜组分中。 因此，本发明人已经发现，TAT-001与异常发育和生长有关，可用作鉴定抗癌化合物的靶标，包括用于免疫治疗的抗体。 因此，本发明提供了用于鉴定抑制TAT-001表达或活性的化合物的方法，包括：使候选化合物与TAT-001接触并检测所述化合物与所述TAT-001之间是否存在结合，或 检测TAT-001表达或活性的变化。 还包括用于鉴定调节TAT-001表达或活性的抗癌化合物和化合物的方法，包括：向细胞或细胞群施用化合物，并检测TAT-001表达或活性的变化。

公开(公告)号：US20100183630A1

公开(公告)日：2010-07-22

申请号：US11922881

申请日：2006-06-29

申请人： Marcelo Filgueira ,  Daniel Chelsky ,  Joel Lanoix ,  Kevin Eng ,  Pierre Thibault ,  Denis Faubert ,  Navdeep Jaitly ,  Sylvain Brunet ,  Frank R.M. Aguilera ,  John S.-C. Tsang ,  Michael Hu ,  Joachim B. Ostermann ,  Marguerite Boulos ,  Paul E. Kearney ,  Heather Butler ,  Sajani Swamy ,  Lyes Hamaidi

发明人： Marcelo Filgueira ,  Daniel Chelsky ,  Joel Lanoix ,  Kevin Eng ,  Pierre Thibault ,  Denis Faubert ,  Navdeep Jaitly ,  Sylvain Brunet ,  Frank R.M. Aguilera ,  John S.-C. Tsang ,  Michael Hu ,  Joachim B. Ostermann ,  Marguerite Boulos ,  Paul E. Kearney ,  Heather Butler ,  Sajani Swamy ,  Lyes Hamaidi

IPC分类号： C07K16/30 ,  C07K16/46 ,  A61K39/395 ,  G01N33/574 ,  A61P35/04

CPC分类号： G01N33/57419 ,  A01K2217/05 ,  A01K2217/075 ,  C07K14/4748 ,  G01N2500/04

摘要： Surprisingly, the present inventors have discovered that expression of TAT-005 protein in human patients is associated with cancer, and that the over-expressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-005 is associated with abnormal development and growth, and may be useful as a target for the identification of anti-cancer com\ pounds, including antibodies for use in immunotherapy. Accordingly, the present invention provides methods for the identification of compounds that inhibit TAT-005 expression or activity, comprising: contacting a candidate compound with a TAT-005 and detecting the presence or absence of binding between said compound and said TAT-005, or detecting a change in TAT-005 expression or activity. Methods are also included for the identification of compounds that modulate TAT-005 expression or activity, comprising: administering a compound to a cell or cell population, and detecting a change in TAT-005 expression or activity. The methods of the invention are useful for the identification of anti-cancer compounds.

摘要翻译： 令人惊奇的是，本发明人已经发现，人类患者中TAT-005蛋白的表达与癌症相关，并且过度表达的蛋白质存在于质膜组分中。 因此，本发明人已经发现，TAT-005与异常发育和生长相关，并且可用作鉴定抗癌药物的靶标，包括用于免疫治疗的抗体。 因此，本发明提供了用于鉴定抑制TAT-005表达或活性的化合物的方法，包括：使候选化合物与TAT-005接触并检测所述化合物与所述TAT-005之间是否存在结合，或 检测TAT-005表达或活性的变化。 还包括用于鉴定调节TAT-005表达或活性的化合物的方法，包括：向细胞或细胞群体施用化合物，并检测TAT-005表达或活性的变化。 本发明的方法可用于鉴定抗癌化合物。

公开(公告)号：US20070150812A1

公开(公告)日：2007-06-28

申请号：US11317773

申请日：2005-12-23

申请人： Michael Hu

发明人： Michael Hu

IPC分类号： G06F17/00

CPC分类号： G06Q10/10

摘要： A user support system and related user interface that integrates FAQ features and helpdesk features. The user interface screen includes menu windows that allow the user to select a main category and a subcategory of the support topic, and displays a list of frequently asked questions (FAQ) based on the user-selected main category and subcategory. A message input window and associated metadata windows are also displayed on the user interface screen, which allow the user to send a question to the support provider. The support provider then communicates with the user through email or other means to provide answers to the user's questions. Optionally, after the support request is resolved, the question and answer may be used to update the FAQ database, taking into consideration the category and subcategory already selected by the user.

摘要翻译： 用户支持系统和相关的用户界面，集成了FAQ功能和帮助台功能。 用户界面屏幕包括允许用户选择支持主题的主要类别和子类别的菜单窗口，并且基于用户选择的主类别和子类别显示常见问题（FAQ）的列表。 消息输入窗口和关联的元数据窗口也显示在用户界面屏幕上，这允许用户向支持提供商发送问题。 支持提供商然后通过电子邮件或其他方式与用户通信，以提供用户问题的答案。 可选地，在解决支持请求之后，可以使用问题和答案来更新FAQ数据库，同时考虑到用户已经选择的类别和子类别。

公开(公告)号：US07011245B1

公开(公告)日：2006-03-14

申请号：US10981717

申请日：2004-11-05

申请人： Michael Hu

发明人： Michael Hu

IPC分类号： G06F17/00

CPC分类号： G07D7/0047

摘要： Parallel and reflective coding structures inclusive of data from both parties to a transaction are propagated beginning with an algorithm derived maker's code, an item code unique to and associated with a single article made by a maker, and data identifying both the maker and the legitimate acquirer. Use of secure hash algorithms, single and double key encryption are suggested to obtain two virtually irreversible parallel coding structures that reflect the identities of the current and previous owner and are also mathematically reflective in that one code is derivable by either code structure in verification of both authenticity and ownership. Multiple modes of verification with coding printed on a receipt for the article are provided including Internet, offline computer, land line and SMS cellular telephone. Authenticity, non-repudiation, proof of legitimate ownership and provenance are provided for any article of value including pharmaceuticals and other consumable product warranting authentification.

摘要翻译： 平行和反射编码结构包括来自交易双方的数据，首先从算法派生制作者的代码，独立于制造商制作的单个文章的关联项目代码以及识别制造商和合法收购方的数据开始传播 。 建议使用安全散列算法，单密钥和双密钥加密来获得反映当前和前一个所有者的身份的两个实际上不可逆的并行编码结构，并且在数学上也是反思性的，因为一个代码可以通过验证两者的代码结构 真实性和所有权。 提供了打印在文章收据上的编码的多种验证模式，包括互联网，离线计算机，陆线和SMS蜂窝电话。 为任何有价值的物品提供真实性，不可否认性，合法所有权和来源证明，包括药品和其他消费品保证认证。

公开(公告)号：US20050014850A1

公开(公告)日：2005-01-20

申请号：US10623395

申请日：2003-07-18

申请人： Michael Hu

发明人： Michael Hu

IPC分类号： B01F3/08 ,  B01F3/12 ,  C01G23/00 ,  C04B35/632

CPC分类号： C04B35/632 ,  B82Y30/00 ,  C01G23/003 ,  C01P2004/04 ,  C01P2004/64 ,  C01P2006/40 ,  C04B35/6264 ,  C04B35/63 ,  C04B2235/3234 ,  C04B2235/449

摘要： Disclosed is a method for making amorphous spherical particles of zirconium titanate and crystalline spherical particles of zirconium titanate comprising the steps of mixing an aqueous solution of zirconium salt and an aqueous solution of titanium salt into a mixed solution having equal moles of zirconium and titanium and having a total salt concentration in the range from 0.01 M to about 0.5 M. A stearic dispersant and an organic solvent is added to the mixed salt solution, subjecting the zirconium salt and the titanium salt in the mixed solution to a coprecipitation reaction forming a solution containing amorphous spherical particles of zirconium titanate wherein the volume ratio of the organic solvent to aqueous part is in the range from 1 to 5. The solution of amorphous spherical particles is incubated in an oven at a temperature ≦100° C. for a period of time ≦24 hours converting the amorphous particles to fine or ultrafine crystalline spherical particles of zirconium titanate.

摘要翻译： 公开了一种制备钛酸锆的无定形球形颗粒和钛酸锆的结晶球形颗粒的方法，包括以下步骤：将锆盐水溶液和钛盐水溶液混合到具有相等摩尔数的锆和钛的混合溶液中，并具有 总盐浓度在0.01M至约0.5M的范围内。将硬脂分散剂和有机溶剂加入到混合盐溶液中，使锆盐和钛盐在混合溶液中进行共沉淀反应，形成含有 钛酸锆的无定形球形颗粒，其中有机溶剂与水性部分的体积比在1至5的范围内。将无定形球形颗粒溶液在温度<= 100℃的烘箱中温育一段时间 时间<= 24小时，将无定形颗粒转变成钛酸锆的细晶或超细结晶球形颗粒。

公开(公告)号：US20070100969A1

公开(公告)日：2007-05-03

申请号：US11262649

申请日：2005-10-31

申请人： Michael Hu

发明人： Michael Hu

IPC分类号： G06F15/177

CPC分类号： G06F9/44505

摘要： A method and system for automatically configuring software distributed through a network. A server of the software vendor gathers certain information such as the user's name during a software download or purchase process, and generates a custom webpage containing software configuration information and/or a user id. The software being distributed includes an automatic configuration program. When the software is launched, the automatic configuration program finds the custom webpage and scrapes the necessary configuration information from it. The automatic configuration program then automatically configures the downloaded software using the configuration information. The automatic configuration program may also obtain additional configuration information from the server using the id contained in the custom webpage.

摘要翻译： 一种用于自动配置通过网络分发的软件的方法和系统。 软件供应商的服务器在软件下载或购买过程中收集诸如用户名的某些信息，并生成包含软件配置信息和/或用户ID的自定义网页。 正在分发的软件包括自动配置程序。 当软件启动时，自动配置程序会找到自定义网页并从中删除必要的配置信息。 然后，自动配置程序使用配置信息自动配置下载的软件。 自动配置程序还可以使用自定义网页中包含的id从服务器获取附加的配置信息。

公开(公告)号：US20070033269A1

公开(公告)日：2007-02-08

申请号：US11496963

申请日：2006-07-31

申请人： Gregory Atkinson ,  Michael Hu

发明人： Gregory Atkinson ,  Michael Hu

IPC分类号： G06F15/16

CPC分类号： H04L67/20 ,  G06Q10/10 ,  G06Q30/02

摘要： A computer-implemented method employs message windows in a functional bar (e.g., toolbar, status bar, address bar, task bar, etc.) embedded in a software program to display messages (including text, images, animation, video, audio, etc.), where the messages displayed in the windows are based on searches conducted by the user. The software program in which the windows are embedded may be a browser or non-browser application. The messages displayed in the windows are downloaded from a server connected to the computer. In one embodiment, the messages are downloaded when the computer is connected to the server and stored on the computer, and later displayed in the message windows when the computer is not connected to the server. The method can be used to display advertisement or to allow organizations to communicate with their constituents. The method allows advertisers and organizations to select subgroups of users to direct their messages to.

摘要翻译： 计算机实现的方法在嵌入在软件程序中的功能栏（例如，工具栏，状态栏，地址栏，任务栏等）中使用消息窗口来显示消息（包括文本，图像，动画，视频，音频等） 。），其中窗口中显示的消息是基于用户进行的搜索。 嵌入Windows的软件程序可能是浏览器或非浏览器应用程序。 窗口中显示的消息是从连接到计算机的服务器下载的。 在一个实施例中，当计算机连接到服务器并存储在计算机上时，下载消息，并且当计算机未连接到服务器时随后显示在消息窗口中。 该方法可用于显示广告或允许组织与其成员通信。 该方法允许广告商和组织选择用户的子组来指导他们的消息。