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公开(公告)号：US20070106065A1
公开(公告)日：2007-05-10
申请号：US11344933
申请日：2006-01-31
申请人： Paul Kearney , Heather Butler , Navdeep Jaitly , Sajani Swamy , Lyes Hamaidi , Marcelo Filgueira , Pierre Thibault , Denis Faubert , Daniel Chelsky , Joel Lanoix , Sylvain Brunet , Kevin Eng , Frank Aguilera , John Tsang , Michael Hu , Joachim Ostermann , Marguerite Boulos
发明人： Paul Kearney , Heather Butler , Navdeep Jaitly , Sajani Swamy , Lyes Hamaidi , Marcelo Filgueira , Pierre Thibault , Denis Faubert , Daniel Chelsky , Joel Lanoix , Sylvain Brunet , Kevin Eng , Frank Aguilera , John Tsang , Michael Hu , Joachim Ostermann , Marguerite Boulos
CPC分类号： C07K14/82 , C07K14/4748 , C07K16/3046
摘要： Surprisingly, the present inventors have discovered that expression of TAT-001 protein in human patients is associated with cancer, and that the overexpressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-001 is associated with abnormal development and growth, and may be useful as a target for the identification of anti-cancer compounds, including antibodies for use in immunotherapy. Accordingly, the present invention provides methods for the identification of compounds that inhibit TAT-001 expression or activity, comprising: contacting a candidate compound with a TAT-001 and detecting the presence or absence of binding between said compound and said TAT-001, or detecting a change in TAT-001 expression or activity. Methods are also included for the identification of anti-cancer compounds and compounds that modulate TAT-001 expression or activity, comprising: administering a compound to a cell or cell population, and detecting a change in TAT-001 expression or activity.
摘要翻译： 令人惊奇的是，本发明人已经发现，人类患者中TAT-001蛋白的表达与癌症有关，并且过表达的蛋白质存在于质膜组分中。 因此，本发明人已经发现，TAT-001与异常发育和生长有关，可用作鉴定抗癌化合物的靶标，包括用于免疫治疗的抗体。 因此，本发明提供了用于鉴定抑制TAT-001表达或活性的化合物的方法，包括：使候选化合物与TAT-001接触并检测所述化合物与所述TAT-001之间是否存在结合，或 检测TAT-001表达或活性的变化。 还包括用于鉴定调节TAT-001表达或活性的抗癌化合物和化合物的方法，包括：向细胞或细胞群施用化合物，并检测TAT-001表达或活性的变化。
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公开(公告)号：US20100183630A1
公开(公告)日：2010-07-22
申请号：US11922881
申请日：2006-06-29
申请人： Marcelo Filgueira , Daniel Chelsky , Joel Lanoix , Kevin Eng , Pierre Thibault , Denis Faubert , Navdeep Jaitly , Sylvain Brunet , Frank R.M. Aguilera , John S.-C. Tsang , Michael Hu , Joachim B. Ostermann , Marguerite Boulos , Paul E. Kearney , Heather Butler , Sajani Swamy , Lyes Hamaidi
发明人： Marcelo Filgueira , Daniel Chelsky , Joel Lanoix , Kevin Eng , Pierre Thibault , Denis Faubert , Navdeep Jaitly , Sylvain Brunet , Frank R.M. Aguilera , John S.-C. Tsang , Michael Hu , Joachim B. Ostermann , Marguerite Boulos , Paul E. Kearney , Heather Butler , Sajani Swamy , Lyes Hamaidi
IPC分类号： C07K16/30 , C07K16/46 , A61K39/395 , G01N33/574 , A61P35/04
CPC分类号： G01N33/57419 , A01K2217/05 , A01K2217/075 , C07K14/4748 , G01N2500/04
摘要： Surprisingly, the present inventors have discovered that expression of TAT-005 protein in human patients is associated with cancer, and that the over-expressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-005 is associated with abnormal development and growth, and may be useful as a target for the identification of anti-cancer com\ pounds, including antibodies for use in immunotherapy. Accordingly, the present invention provides methods for the identification of compounds that inhibit TAT-005 expression or activity, comprising: contacting a candidate compound with a TAT-005 and detecting the presence or absence of binding between said compound and said TAT-005, or detecting a change in TAT-005 expression or activity. Methods are also included for the identification of compounds that modulate TAT-005 expression or activity, comprising: administering a compound to a cell or cell population, and detecting a change in TAT-005 expression or activity. The methods of the invention are useful for the identification of anti-cancer compounds.
摘要翻译： 令人惊奇的是，本发明人已经发现，人类患者中TAT-005蛋白的表达与癌症相关，并且过度表达的蛋白质存在于质膜组分中。 因此，本发明人已经发现，TAT-005与异常发育和生长相关，并且可用作鉴定抗癌药物的靶标，包括用于免疫治疗的抗体。 因此，本发明提供了用于鉴定抑制TAT-005表达或活性的化合物的方法，包括：使候选化合物与TAT-005接触并检测所述化合物与所述TAT-005之间是否存在结合，或 检测TAT-005表达或活性的变化。 还包括用于鉴定调节TAT-005表达或活性的化合物的方法，包括：向细胞或细胞群体施用化合物，并检测TAT-005表达或活性的变化。 本发明的方法可用于鉴定抗癌化合物。
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公开(公告)号：US20060031023A1
公开(公告)日：2006-02-09
申请号：US11246325
申请日：2005-10-06
申请人： Frank Aguilera , Denis Faubert , Marguerite Boulos , John Tsang , Michael Hu , Joachim Ostermann , Paul Kearney , Pierre Thibault
发明人： Frank Aguilera , Denis Faubert , Marguerite Boulos , John Tsang , Michael Hu , Joachim Ostermann , Paul Kearney , Pierre Thibault
CPC分类号： G01N33/6848 , Y10T436/24
摘要： The present invention is directed to computer automated methods and systems for identifying and characterizing biomolecules in a biological sample. Mass spectrometry measurements are obtained on biomolecules in a sample. These measurements are analyzed to determine the abundance of the biomolecules in the sample, and the abundance measurements are coupled with one or more distinguishing characteristics of biomolecules they are associated with, thereby permitting computer-mediated comparison of abundances of biomolecules from multiple biological samples.
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公开(公告)号：US20060269944A1
公开(公告)日：2006-11-30
申请号：US11429113
申请日：2006-05-04
申请人： Frank Aguilera , Denis Faubert , Marguerite Boulos , John Tsang , Michael Hu , Joachim Ostermann , Paul Kearney , Pierre Thibault
发明人： Frank Aguilera , Denis Faubert , Marguerite Boulos , John Tsang , Michael Hu , Joachim Ostermann , Paul Kearney , Pierre Thibault
CPC分类号： G01N33/6848 , Y10T436/24
摘要： The present invention is directed to computer automated methods and systems for identifying and characterizing biomolecules in a biological sample. Mass spectrometry measurements are obtained on biomolecules in a sample. These measurements are analyzed to determine the abundance of the biomolecules in the sample, and the abundance measurements are coupled with one or more distinguishing characteristics of biomolecules they are associated with, thereby permitting computer-mediated comparison of abundances of biomolecules from multiple biological samples.
摘要翻译： 本发明涉及用于识别和表征生物样品中生物分子的计算机自动化方法和系统。 在样品中的生物分子上获得质谱测量。 分析这些测量以确定样品中生物分子的丰度，并且丰度测量与其相关联的生物分子的一个或多个区别特征相结合，从而允许计算机介导的来自多个生物样品的生物分子丰度的比较。
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公开(公告)号：US20060003385A1
公开(公告)日：2006-01-05
申请号：US11188954
申请日：2005-07-25
申请人： Frank Aguilera , Denis Faubert , Marguerite Boulos , John Tsang , Michael Hu , Joachim Ostermann , Paul Kearney , Pierre Thibault
发明人： Frank Aguilera , Denis Faubert , Marguerite Boulos , John Tsang , Michael Hu , Joachim Ostermann , Paul Kearney , Pierre Thibault
CPC分类号： G01N33/6848 , Y10T436/24
摘要： The present invention is directed to computer automated methods and systems for identifying and characterizing biomolecules in a biological sample. Mass spectrometry measurements are obtained on biomolecules in a sample. These measurements are analyzed to determine the abundance of the biomolecules in the sample, and the abundance measurements are coupled with one or more distinguishing characteristics of biomolecules they are associated with, thereby permitting computer-mediated comparison of abundances of biomolecules from multiple biological samples.
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公开(公告)号：US6124675A
公开(公告)日：2000-09-26
申请号：US88079
申请日：1998-06-01
CPC分类号： H01J49/102 , H01J27/04
摘要： The metastable atom bombardment source provides a charged particle free beam of metastable species that can be used to bombard and ionize organic and inorganic substances in a gas phase. The metastable atoms are produced by inducing a discharge in a gas (rare gases or small molecules). The discharge is curved between the cathode and anode, with the cathode located in a medium pressure zone and the anode located off-axis in a low pressure zone; A nozzle located between the cathode and the anode provides a collimated beam of metastable atoms of low kinetic energy that is directed at an ion volume containing the substances to be analyzed.
摘要翻译： 亚稳态原子轰击源提供了一种可带电粒子的亚稳态物质束，可用于轰击和离子化气相中的有机和无机物质。 亚稳态原子通过在气体（稀有气体或小分子）中的排放而产生。 放电在阴极和阳极之间弯曲，阴极位于中压区域，阳极位于低压区域的轴外; 位于阴极和阳极之间的喷嘴提供准直的低动能的亚稳态原子束，其指向含有待分析物质的离子体积。
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