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公开(公告)号：US08404834B2
公开(公告)日：2013-03-26
申请号：US12747981
申请日：2008-12-15
申请人： Frank Hacket , Thomas Hey , Franziska Hauschild , Helmut Knoller , Martin Schimmel , Klaus Sommermeyer
发明人： Frank Hacket , Thomas Hey , Franziska Hauschild , Helmut Knoller , Martin Schimmel , Klaus Sommermeyer
CPC分类号： C08B31/00 , A61K47/61 , C08B31/125
摘要： The invention relates to a method for the preparation of a hydroxyalkyl starch derivative which comprises reacting hydroxyalkyl starch (HAS) via the optionally oxidized reducing end of the HAS with the amino group M of a crosslinking compound which, apart from the amino group, comprises a specifically protected carbonyl group, namely an acetal group or a ketal group.
摘要翻译： 本发明涉及一种制备羟烷基淀粉衍生物的方法，其包括将羟烷基淀粉（HAS）经由任选氧化的HAS还原端与交联化合物的氨基M反应，所述交联化合物除了氨基外，还包含 特别保护的羰基，即缩醛基或缩酮基。
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公开(公告)号：US20100305033A1
公开(公告)日：2010-12-02
申请号：US12747981
申请日：2008-12-15
申请人： Frank Hacket , Thomas Hey , Franziska Hauschild , Helmut Knoller , Martin Schimmel , Klaus Sommermeyer
发明人： Frank Hacket , Thomas Hey , Franziska Hauschild , Helmut Knoller , Martin Schimmel , Klaus Sommermeyer
IPC分类号： A61K31/718 , A61P19/10 , A61P7/04 , A61P37/04 , A61P35/00 , A61P35/02 , A61P7/06 , A61P29/00 , A61P43/00 , A61P11/00 , C08B31/00 , C07K17/10
CPC分类号： C08B31/00 , A61K47/61 , C08B31/125
摘要： The invention relates to a method for the preparation of a hydroxyalkyl starch derivative which comprises reacting hydroxyalkyl starch (HAS) via the optionally oxidised reducing end of the HAS with the amino group M of a crosslinking compound which, apart from the amino group, comprises a specifically protected carbonyl group, namely an acetal group or a ketal group.
摘要翻译： 本发明涉及一种制备羟烷基淀粉衍生物的方法，其包括将羟烷基淀粉（HAS）经由任选氧化的HAS还原端与交联化合物的氨基M反应，所述交联化合物除氨基以外还包含 特别保护的羰基，即缩醛基或缩酮基。
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3.发明申请公开(公告)号：US20100297078A1
公开(公告)日：2010-11-25
申请号：US12747972
申请日：2008-12-15
申请人： Frank Hacket , Wolfram Eichner , Helmut Knoller , Andreas Mitsch , Martin Schimmel , Norbert Zander , Franziska Hauschild
发明人： Frank Hacket , Wolfram Eichner , Helmut Knoller , Andreas Mitsch , Martin Schimmel , Norbert Zander , Franziska Hauschild
IPC分类号： A61K38/21 , C08B31/12 , C07K14/56 , C07K14/505 , C07K14/535 , C07H7/02 , C07K1/00 , A61K38/18 , A61P35/00 , A61P35/02 , A61P1/16 , A61P7/06 , A61P13/12 , A61P31/18
摘要： A method of producing a hydroxyalkyl starch (HAS) derivative, comprising a) reacting optionally oxidized hydroxyalkyl starch with a compound (D) comprising at least two functional groups —O—NH2 or a salt thereof, and b) reacting the hydroxyalkyl starch derivative obtained in step a) with a compound (L) comprising at least two functional groups W1 and W2 independently selected from the group consisting of an aldehyde group, a suitably protected aldehyde group, a keto group, and a suitably protected keto group.
摘要翻译： 一种制备羟烷基淀粉（HAS）衍生物的方法，包括：a）任选地氧化的羟烷基淀粉与包含至少两个官能团-O-NH 2或其盐的化合物（D）反应，和b）使获得的羟烷基淀粉衍生物 在步骤a）中，使用包含至少两个官能团W1和W2的化合物（L），其独立地选自醛基，适当保护的醛基，酮基和适当保护的酮基。
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公开(公告)号：US08840879B2
公开(公告)日：2014-09-23
申请号：US13018648
申请日：2011-02-01
申请人： Wolfram Eichner , Martin Schimmel , Frank Hacket , Elmar Kraus , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Langer , Michele Orlando , Klaus Sommermeyer
发明人： Wolfram Eichner , Martin Schimmel , Frank Hacket , Elmar Kraus , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Langer , Michele Orlando , Klaus Sommermeyer
摘要： Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a covalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. Methods of producing the conjugates and the use of the conjugates also are provided herein.
摘要翻译： 本文提供羟烷基淀粉和蛋白质的缀合物。 共轭物通过羟烷基淀粉或羟烷基淀粉和蛋白质的衍生物之间的共价键形成。 本文还提供了产生缀合物的方法和缀合物的用途。
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公开(公告)号：US20090047251A1
公开(公告)日：2009-02-19
申请号：US11518558
申请日：2006-09-08
申请人： Wolfram Eichner , Martin Schimmel , Frank Hacket , Elmar Kraus , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Langer , Michele Orlando , Klaus Sommermeyer
发明人： Wolfram Eichner , Martin Schimmel , Frank Hacket , Elmar Kraus , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Langer , Michele Orlando , Klaus Sommermeyer
摘要： Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a convalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. Methods of producing the conjugates and the use of the conjugates also are provided herein.
摘要翻译： 本文提供羟烷基淀粉和蛋白质的缀合物。 缀合物通过羟烷基淀粉或羟烷基淀粉和蛋白质的衍生物之间的共价连接形成。 本文还提供了产生缀合物的方法和缀合物的用途。
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公开(公告)号：US20110200555A1
公开(公告)日：2011-08-18
申请号：US13018648
申请日：2011-02-01
申请人： Wolfram Eichner , Martin Schimmel , Frank Hacket , Elmar Kraus , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Langer , Michele Orlando , Klaus Sommermeyer
发明人： Wolfram Eichner , Martin Schimmel , Frank Hacket , Elmar Kraus , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Langer , Michele Orlando , Klaus Sommermeyer
IPC分类号： A61K38/21 , C07K14/565 , C07K14/535 , C12N9/96 , C07K14/81 , C07K14/755 , C07K1/107 , C12P21/00 , A61K38/19 , A61K38/48 , A61K38/57 , A61K38/37 , A61P25/00 , A61P7/00 , A61P7/02 , A61P9/10 , A61P11/00 , A61P17/00 , A61P7/04
摘要： Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a convalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. Methods of producing the conjugates and the use of the conjugates also are provided herein.
摘要翻译： 本文提供羟烷基淀粉和蛋白质的缀合物。 缀合物通过羟烷基淀粉或羟烷基淀粉和蛋白质的衍生物之间的共价连接形成。 本文还提供了产生缀合物的方法和缀合物的用途。
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公开(公告)号：US08017739B2
公开(公告)日：2011-09-13
申请号：US11518558
申请日：2006-09-08
申请人： Wolfram Eichner , Martin Schimmel , Frank Hacket , Elmar Kraus , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Langer , Michele Orlando , Klaus Sommermeyer
发明人： Wolfram Eichner , Martin Schimmel , Frank Hacket , Elmar Kraus , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Langer , Michele Orlando , Klaus Sommermeyer
摘要： Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a convalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. Methods of producing the conjugates and the use of the conjugates also are provided herein.
摘要翻译： 本文提供羟烷基淀粉和蛋白质的缀合物。 缀合物通过羟烷基淀粉或羟烷基淀粉和蛋白质的衍生物之间的共价连接形成。 本文还提供了产生缀合物的方法和缀合物的用途。
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公开(公告)号：US20140073602A9
公开(公告)日：2014-03-13
申请号：US13809199
申请日：2011-07-11
CPC分类号： C08B31/125 , A61K47/61 , C08L3/08
摘要： The present invention relates to nitric oxide delivering hydroxyalkyl starch derivatives, methods of preparing the same, and specific uses of these hydroxyalkyl starch derivatives.
摘要翻译： 本发明涉及一氧化氮递送羟烷基淀粉衍生物，其制备方法以及这些羟烷基淀粉衍生物的具体用途。
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公开(公告)号：US20050036979A1
公开(公告)日：2005-02-17
申请号：US10859923
申请日：2004-06-03
申请人： Wolfgang Metzger , Veit Otto , Walter Ruger , Martin Schimmel
发明人： Wolfgang Metzger , Veit Otto , Walter Ruger , Martin Schimmel
CPC分类号： B01J20/261 , A61M1/3679 , B01J20/26 , B01J20/265 , B01J20/28004 , B01J20/28019 , B01J20/28083 , B01J20/28085 , C08F8/12 , C08F2810/20 , C08F2220/325
摘要： This invention relates to an adsorbent for lowering the concentration of fibrinogen and/or fibrin in the blood or blood plasma, encompassing an organic matrix with synthetic side chains covalently bound to the matrix and exhibiting terminal vicinal hydroxy groups formed by the hydrolysis of terminal epoxy groups, which synthetic side chains are free of peptides and of any groups of aromatics. The invention further relates to a method for preparing the adsorbent, and to the use of the adsorbent for producing an adsorber serving to lower the concentration of fibrinogen and/or fibrin in the blood or blood plasma.
摘要翻译： 本发明涉及一种用于降低血液或血浆中纤维蛋白原和/或纤维蛋白浓度的吸附剂，其包含与基质共价结合的合成侧链的有机基质，并显示由末端环氧基团水解形成的末端连位羟基 ，哪些合成侧链没有肽和任何芳香族组。 本发明还涉及一种制备吸附剂的方法，以及使用该吸附剂制备用于降低血液或血浆中纤维蛋白原和/或纤维蛋白浓度的吸附剂。
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公开(公告)号：US20130184237A1
公开(公告)日：2013-07-18
申请号：US13809199
申请日：2011-07-11
CPC分类号： C08B31/125 , A61K47/61 , C08L3/08
摘要： The present invention relates to nitric oxide delivering hydroxyalkyl starch derivatives, methods of preparing the same, and specific uses of these hydroxyalkyl starch derivatives.
摘要翻译： 本发明涉及一氧化氮递送羟烷基淀粉衍生物，其制备方法以及这些羟烷基淀粉衍生物的具体用途。
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