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40 条记录 (耗时 0.041 秒)

    Method for producing a two-chamber arrangement, and such a two-chamber arrangement
    8.
    发明授权
    Method for producing a two-chamber arrangement, and such a two-chamber arrangement 有权
    用于制造双室装置的方法，以及这种两室装置

    公开(公告)号：US06712202B2

    公开(公告)日：2004-03-30

    申请号：US09925894

    申请日：2001-08-09

    申请人： Hans-Jorg Muller ,  Klaus Sommermeyer ,  Bernd Eschenbach

    发明人： Hans-Jorg Muller ,  Klaus Sommermeyer ,  Bernd Eschenbach

    IPC分类号： B65D8132

    CPC分类号： A61J1/2093 ,  A61J1/10 ,  A61J1/2024 ,  A61J1/2027

    摘要： To produce a two-chamber arrangement having a first chamber, which is filled with a first component, and a second chamber, which is filled with a second component, two separate bags are sterilized and filled independently of each other with the first/second component. Only after the bags have been sterilized and filled are they connected to each other in such a way that the component contained in one chamber can be transferred into the other chamber so as to be able to mix the two components together. Once they have been filled, the first and second bags are preferably sealed with an openable peel seam, after which the bag ends are welded together.

    摘要翻译： 为了产生具有填充有第一部件的第一腔室和填充有第二部件的第二腔室的两腔室装置，两个单独的袋子被彼此独立地灭菌并且被填充有第一/第二部件 。 只有在袋被灭菌和填充之后，它们彼此连接，使得容纳在一个室中的组分可以被转移到另一个室中，以便能够将两个组分混合在一起。 一旦它们被填充，第一和第二袋优选用可打开的剥离缝密封，之后将袋端焊接在一起。

    Dialysis solution for peritoneal dialysis
    9.
    发明授权
    Dialysis solution for peritoneal dialysis 失效
    透析溶液用于腹膜透析

    公开(公告)号：US06284140B1

    公开(公告)日：2001-09-04

    申请号：US08815442

    申请日：1997-03-11

    申请人： Klaus Sommermeyer ,  Jutta Passlick-Deetjen

    发明人： Klaus Sommermeyer ,  Jutta Passlick-Deetjen

    IPC分类号： A61M128

    CPC分类号： A61K31/715 ,  A61M1/287 ,  Y10S514/929

    摘要： The present invention relates to dialysis solutions for peritoneal dialysis, containing hydroxyethyl starch as the osmotically-active substance, electrolytes and, optionally, conventional additives, where the hydroxyethyl starch has a molecular weight Mw in the range from 10,000 to 150,000, a substitution MS in the range from 0.10 to 0.40, a substitution DS in the range from 0.09 to 0.35 and a substitution ratio C2/C6≧8. With this peritoneal dialysis solution it is possible, with an outstanding ultrafiltration, to maintain a longer dwell time, for example the dialysis solution can be utilized for a period of 12 hours in the CAPD without replacement. In addition, the inventive dialysis solution is also particularly advantageous for patients with residual kidney function. The resorption of the osmotically active substance is clearly diminished and even after a dwell time of 12 hours it amounts to a maximum of 60-70%.

    摘要翻译： 本发明涉及用于腹膜透析的透析溶液，其包含羟乙基淀粉作为渗透活性物质，电解质和任选的常规添加剂，其中羟乙基淀粉的分子量Mw为10,000至150,000，取代MS为 在0.10至0.40的范围内，取代DS在0.09至0.35的范围内，取代率C2 / C6> = 8。 使用这种腹膜透析溶液，通过卓越的超滤可以保持更长的停留时间，例如透析溶液可以在CAPD中使用12小时而不需要更换。 此外，本发明的透析溶液对于具有残留肾功能的患者也是特别有利的。 渗透活性物质的吸收明显减少，即使在停留时间为12小时后，其最多达到60-70％。

    Coupling Proteins to a Modified Polysaccharide
    10.
    发明申请
    Coupling Proteins to a Modified Polysaccharide 有权
    将蛋白质偶联到改性多糖

    公开(公告)号：US20090233847A1

    公开(公告)日：2009-09-17

    申请号：US12473462

    申请日：2009-05-28

    申请人： Jurgen Hemberger ,  Michele Orlando ,  Klaus Sommermeyer ,  Wolfram Eichner ,  Sven Frie ,  Katharina Lutterbeck ,  Cornelius Jungheinrich ,  Roland Scharpf

    发明人： Jurgen Hemberger ,  Michele Orlando ,  Klaus Sommermeyer ,  Wolfram Eichner ,  Sven Frie ,  Katharina Lutterbeck ,  Cornelius Jungheinrich ,  Roland Scharpf

    IPC分类号： A61K38/17 ,  C07K14/47

    CPC分类号： C08B31/185 ,  A61K47/61 ,  C08B31/00 ,  C08B31/18 ,  C08H1/00

    摘要： The invention relates to a method for coupling proteins to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the protein is based on a covalent bond which is the result of a coupling reaction between the terminal aldehyde group or a functional group of the modified polysaccharide molecule resulting from the chemical reaction of this aldehyde group and a functional group of the protein which reacts with the aldehyde group or with the resulting functional group of the polysaccharide molecule. The bond directly resulting from the coupling reaction can be optionally modified by a further reaction to the aforementioned covalent bond. The invention further relates to pharmaceutical compositions that comprise conjugates formed in this coupling process and to the use of conjugates and compositions for the prophylaxis or therapy of the human or animal body.

    摘要翻译： 本发明涉及将蛋白质与淀粉衍生的改性多糖偶联的方法。 改性多糖和蛋白质之间的结合相互作用是基于共价键，其是由该醛基的化学反应引起的末端醛基或改性多糖分子的官能团之间的偶联反应的结果， 与醛基反应的蛋白质组或与所得多糖分子的官能团反应的蛋白质组。 可以通过进一步与上述共价键的反应来任意地修饰由偶联反应直接得到的键。 本发明还涉及药物组合物，其包含在该偶联过程中形成的缀合物以及用于预防或治疗人或动物体的缀合物和组合物的用途。