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    Noninvasive devices, methods, and systems for shrinking of tissues
    1.
    发明授权
    Noninvasive devices, methods, and systems for shrinking of tissues 有权
    用于收缩组织的无创器件，方法和系统

    公开(公告)号：US06976492B2

    公开(公告)日：2005-12-20

    申请号：US10338193

    申请日：2003-01-07

    申请人： Frank Ingle ,  Garry L. Carter ,  Robert J. Laird ,  John P. Claude ,  Paul Do ,  Brian J. Mosel

    发明人： Frank Ingle ,  Garry L. Carter ,  Robert J. Laird ,  John P. Claude ,  Paul Do ,  Brian J. Mosel

    IPC分类号： A61B18/12 ,  A61B17/00 ,  A61B18/00 ,  A61B18/02 ,  A61B18/14 ,  A61N1/06 ,  A61N1/40 ,  A61B19/00

    CPC分类号： A61B18/1482 ,  A61B18/14 ,  A61B18/1477 ,  A61B18/1485 ,  A61B18/1815 ,  A61B2017/00084 ,  A61B2017/003 ,  A61B2018/00011 ,  A61B2018/00023 ,  A61B2018/00083 ,  A61B2018/00095 ,  A61B2018/00148 ,  A61B2018/0016 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/00505 ,  A61B2018/00517 ,  A61B2018/00523 ,  A61B2018/00553 ,  A61B2018/00559 ,  A61B2018/00791 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1273 ,  A61B2018/1425 ,  A61B2018/1467 ,  A61B2018/1472 ,  A61B2090/3782 ,  A61B2218/002 ,  A61N1/06 ,  A61N1/403 ,  A61N7/02

    摘要： The invention provides improved devices, methods, and systems for shrinking of collagenated tissues, particularly for treating urinary incontinence in a noninvasive manner by directing energy to a patient's own support tissues. This energy heats fascia and other collagenated support tissues, causing them to contract. The energy can be applied intermittently, often between a pair of large plate electrodes having cooled flat electrode surfaces, the electrodes optionally being supported by a clamp structure. Such cooled plate electrodes are capable of directing electrical energy through an intermediate tissue and into fascia while the cooled electrode surface prevents injury to the intermediate tissue, particularly where the electrode surfaces are cooled before, during, and after an intermittent heating cycle. Ideally, the plate electrode comprises an electrode array including discrete electrode surface segments so that the current flux can be varied to selectively target the fascia. Alternatively, chilled “liquid electrodes” may direct current through a selected portion of the bladder (or other body cavity) while also cooling the bladder wall, an insulating gas can prevent heating of an alternative bladder portion and the adjacent tissues, and/or ultrasound transducers direct energy through an intermediate tissue and into fascia with little or no injury to the intermediate tissue. Cooled electrodes may be used to chill an intermediate engaged tissue so as to cause the maximum temperature difference between the target tissue and the intermediate tissue prior to initiating RF heating. This allows the dimensions of tissue reaching the treatment temperature to be controlled and/or minimized, the dimensions of protected intermediate tissue to be maximized, and the like.

    摘要翻译： 本发明提供了用于收缩胶原组织的改进的装置，方法和系统，特别是通过将能量引导到患者自己的支撑组织以非侵入性方式治疗尿失禁。 这种能量加热筋膜和其他胶原支持组织，导致它们收缩。 间歇地施加能量，通常在具有冷却的平坦电极表面的一对大平板电极之间，电极可选地由夹持结构支撑。 这样的冷却板电极能够将电能引导通过中间组织并进入筋膜，同时冷却的电极表面防止对中间组织的损伤，特别是在电极表面在间歇加热循环之前，期间和之后被冷却时。 理想地，平板电极包括包括分立电极表面段的电极阵列，使得可以改变电流通量以选择性地靶向仪表板。 或者，冷却的“液体电极”可以引导电流通过膀胱（或其他体腔）的选定部分，同时还冷却膀胱壁，绝缘气体可以防止替代膀胱部分和相邻组织和/或超声波的加热 换能器将能量通过中间组织直接导入筋膜，对中间组织几乎没有或没有损伤。 冷却的电极可用于冷却中间接合组织，以便在开始RF加热之前引起目标组织和中间组织之间的最大温差。 这允许控制和/或最小化达到治疗温度的组织的尺寸，被保护的中间组织的尺寸被最大化等等。

    Noninvasive devices, methods, and systems for shrinking of tissues
    6.
    发明授权
    Noninvasive devices, methods, and systems for shrinking of tissues 失效
    用于收缩组织的无创器件，方法和系统

    公开(公告)号：US06480746B1

    公开(公告)日：2002-11-12

    申请号：US08910775

    申请日：1997-08-13

    申请人： Frank Ingle ,  Garry L. Carter

    发明人： Frank Ingle ,  Garry L. Carter

    IPC分类号： A61N1818

    CPC分类号： A61B18/1485 ,  A61B18/1815 ,  A61B2017/00084 ,  A61B2017/003 ,  A61B2018/00011 ,  A61B2018/00023 ,  A61B2018/0016 ,  A61B2018/0022 ,  A61B2018/00517 ,  A61B2018/00523 ,  A61B2018/00791 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1273 ,  A61B2018/1467 ,  A61B2018/1472 ,  A61B2090/3782 ,  A61B2218/002 ,  A61N7/02

    摘要： The invention provides improved devices, methods, and systems for shrinking of collagenated tissues, particularly for treating urinary incontinence in a noninvasive manner by directing energy to a patient's own support tissues. This energy gently heats fascia and other collagenated support tissues, causing them to contract. The energy will preferably be applied between a pair of large plate electrodes having cooled flat electrode surfaces. Such cooled plate electrodes are capable of directing electrical energy through an intermediate tissue and into fascia while the cooled electrode surface prevents injury to the intermediate tissue. Ideally, the plate electrode comprises an electrode array including discrete electrode surface segments so that the current flux can be varied to selectively target the fascia.

    摘要翻译： 本发明提供了用于收缩胶原组织的改进的装置，方法和系统，特别是通过将能量引导到患者自己的支撑组织以非侵入性方式治疗尿失禁。 这种能量轻轻地加热筋膜和其他胶原支持组织，导致它们收缩。 能量将优选地施加在具有冷却的平坦电极表面的一对大板电极之间。 这样的冷却板电极能够将电能引导通过中间组织并进入筋膜，同时冷却的电极表面防止对中间组织的损伤。 理想地，平板电极包括包括分立电极表面段的电极阵列，使得可以改变电流通量以选择性地靶向仪表板。

    Apparatus and methods for uniformly distributing coolant within a cryo-ablation device
    7.
    发明授权
    Apparatus and methods for uniformly distributing coolant within a cryo-ablation device 有权
    在冷冻消融装置内均匀分配冷却剂的装置和方法

    公开(公告)号：US08469919B2

    公开(公告)日：2013-06-25

    申请号：US12388399

    申请日：2009-02-18

    申请人： Frank Ingle ,  Raphael Hon

    发明人： Frank Ingle ,  Raphael Hon

    IPC分类号： A61B18/18

    CPC分类号： A61B18/02 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262

    摘要： Apparatus and methods for uniformly distributing coolant within a cryo-ablation device. A nozzle apparatus includes a tubular member having a plurality of angled apertures that induce swirling of coolant streams dispersed through the angled apertures. Coolant swirling round the tubular member and along an inner surface of an inflatable balloon element inflates the balloon element and cryogenically ablate tissue. The swirling action achieved using angled apertures uniformly distributes coolant along the inner surface of the balloon such that the temperatures along an inner surface of the balloon element and ablation of tissue adjacent to the balloon element are substantially uniform.

    摘要翻译： 在冷冻消融装置内均匀分配冷却剂的装置和方法。 喷嘴装置包括管状构件，其具有多个成角度的孔，其引导分散通过倾斜孔的冷却剂流的旋转。 冷却液在管状构件周围旋转并且沿着可充气球囊元件的内表面膨胀，从而使球囊元件膨胀并且低温地烧蚀组织。 使用角度孔使得的旋转动作沿着球囊的内表面均匀地分布冷却剂，使得沿着球囊元件的内表面的温度和与球囊元件相邻的组织的消融基本上是均匀的。

    CARDIAC FUNCTION MONITOR USING INFORMATION INDICATIVE OF LEAD MOTION
    8.
    发明申请
    CARDIAC FUNCTION MONITOR USING INFORMATION INDICATIVE OF LEAD MOTION 有权
    心脏功能监测器使用信号指示铅运动

    公开(公告)号：US20110319778A1

    公开(公告)日：2011-12-29

    申请号：US13168531

    申请日：2011-06-24

    申请人： Robert J. Sweeney ,  Allan C. Shuros ,  Krzysztof Z. Siejko ,  David C. Olson ,  Frank Ingle

    发明人： Robert J. Sweeney ,  Allan C. Shuros ,  Krzysztof Z. Siejko ,  David C. Olson ,  Frank Ingle

    IPC分类号： A61B5/0245 ,  A61N1/365

    CPC分类号： A61N1/36514 ,  A61B5/02133 ,  A61B5/026 ,  A61N1/08 ,  A61N1/36142 ,  A61N1/36578

    摘要： Systems and methods to monitor cardiac function using information indicative of lead motion are described. In an example, a system including an implantable medical device can include a receiver circuit configured to be electrically coupled to conductor comprising a portion of an implantable lead and be configured to obtain information indicative of a movement of the implantable lead due at least in part to a motion of a heart. The system can include a sensing circuit configured to obtain information indicative of cardiac electrical activity. The system can include a processor circuit configured to construct a template representative of a contraction of the heart, where the template can be constructed using the information indicative of the movement of the implantable lead due at least in part to the motion of the heart during the contraction, and using the information indicative of the cardiac electrical activity sensed during the contraction.

    摘要翻译： 描述使用指示引导运动的信息来监测心脏功能的系统和方法。 在一个示例中，包括可植入医疗装置的系统可以包括被配置为电耦合到导体的接收器电路，该导体包括可植入引线的一部分，并且被配置为获得指示可植入引线的移动的信息， 一个心脏的动作。 该系统可以包括被配置为获得指示心脏电活动的信息的感测电路。 该系统可以包括配置成构造代表心脏收缩的模板的处理器电路，其中可以使用指示可植入导线的运动的信息来构建模板，至少部分地由于心脏的运动 并且使用指示在收缩期间感测到的心脏电活动的信息。

    RENAL ARTERY DENERVATION APPARATUS EMPLOYING HELICAL SHAPING ARRANGEMENT
    9.
    发明申请
    RENAL ARTERY DENERVATION APPARATUS EMPLOYING HELICAL SHAPING ARRANGEMENT 审中-公开
    使用正畸形状装置的肾脏ARENY DENERVATION装置

    公开(公告)号：US20110264086A1

    公开(公告)日：2011-10-27

    申请号：US13087163

    申请日：2011-04-14

    申请人： Frank Ingle

    发明人： Frank Ingle

    IPC分类号： A61B18/18

    CPC分类号： A61B18/1492 ,  A61B18/02 ,  A61B2017/00084 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00285 ,  A61B2018/00505 ,  A61B2018/0212 ,  A61B2018/1435

    摘要： Devices, systems, and methods provide for renal sympathetic nerve activity modification and termination. Apparatuses are configured for intravascular delivery of a denervation therapy to a renal artery of a patient, and preferably create a lesion or lesions that define a pattern that completes at least one revolution of the renal artery. Various denervation therapy elements may be employed, including a cryotherapy arrangement, a drug eluting arrangement, an RF ablation arrangement, an ultrasonic ablation catheter, a laser ablation catheter, a microwave ablation catheter, or a combination of these therapy elements.

    摘要翻译： 装置，系统和方法提供肾交感神经活动修饰和终止。 设备被配置用于去神经支配治疗的血管内递送到患者的肾动脉，并且优选地产生限定完成肾动脉至少一圈的模式的损伤或损伤。 可以使用各种去神经治疗元件，包括冷冻治疗装置，药物洗脱装置，RF消融装置，超声消融导管，激光消融导管，微波消融导管或这些治疗元件的组合。

    PHOTOTHERAPY FOR RENAL DENERVATION
    10.
    发明申请
    PHOTOTHERAPY FOR RENAL DENERVATION 审中-公开
    用于肾功能衰竭的摄影

    公开(公告)号：US20110257641A1

    公开(公告)日：2011-10-20

    申请号：US13086121

    申请日：2011-04-13

    申请人： Roger Hastings ,  Frank Ingle ,  Allan C. Shuros ,  Eric Petersen ,  Mark Hollingsworth

    发明人： Roger Hastings ,  Frank Ingle ,  Allan C. Shuros ,  Eric Petersen ,  Mark Hollingsworth

    IPC分类号： A61B18/24

    CPC分类号： A61B18/24 ,  A61B2018/00011 ,  A61B2018/1807 ,  A61B2018/208 ,  A61B2018/263 ,  A61B2090/3782 ,  A61N2007/003

    摘要： Apparatuses and methods facilitate delivery of optical or photoacoustic energy to innervated vascular that contributes to renal sympathetic nerve activity. The optical energy delivered may be of sufficient power to scan or image innervated renal or aortal tissue. The optical energy delivered may be of sufficient power to ablate innervated renal or aortal tissue, such as by thermal laser ablation or photoacoustic laser ablation. A catheter for intravascular or extravascular deployment supports an optical fiber arrangement comprising a coupling for receiving light from a laser light source. An optics arrangement is supported by the catheter and coupled to the optical fiber arrangement. The optics arrangement includes one or more optical elements arranged to receive the laser light and direct optical energy to target innervated tissue or a water source from which a cavitation bubble may be created and launched for acoustically shocking the target innervated tissue.

    摘要翻译： 装置和方法有助于将光学或光声能量传递给有助于肾交感神经活动的神经支配的血管。 输送的光能可能具有足够的功率来扫描或图像支配的肾脏或主动脉组织。 输送的光能可能具有足够的功率来消融支配的肾或主动脉组织，例如通过热激光烧蚀或光声激光烧蚀。 用于血管内或血管外展开的导管支持包括用于接收来自激光光源的光的耦合器的光纤装置。 光学装置由导管支撑并耦合到光纤装置。 光学装置包括一个或多个光学元件，其布置成接收激光并将光能引导到目标主导组织或水源，从该水源可以产生和发射空化气泡用于声学震动目标神经组织。