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    Noninvasive devices, methods, and systems for shrinking of tissues
    1.
    发明授权
    Noninvasive devices, methods, and systems for shrinking of tissues 有权
    用于收缩组织的无创器件，方法和系统

    公开(公告)号：US06976492B2

    公开(公告)日：2005-12-20

    申请号：US10338193

    申请日：2003-01-07

    申请人： Frank Ingle ,  Garry L. Carter ,  Robert J. Laird ,  John P. Claude ,  Paul Do ,  Brian J. Mosel

    发明人： Frank Ingle ,  Garry L. Carter ,  Robert J. Laird ,  John P. Claude ,  Paul Do ,  Brian J. Mosel

    IPC分类号： A61B18/12 ,  A61B17/00 ,  A61B18/00 ,  A61B18/02 ,  A61B18/14 ,  A61N1/06 ,  A61N1/40 ,  A61B19/00

    CPC分类号： A61B18/1482 ,  A61B18/14 ,  A61B18/1477 ,  A61B18/1485 ,  A61B18/1815 ,  A61B2017/00084 ,  A61B2017/003 ,  A61B2018/00011 ,  A61B2018/00023 ,  A61B2018/00083 ,  A61B2018/00095 ,  A61B2018/00148 ,  A61B2018/0016 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/00505 ,  A61B2018/00517 ,  A61B2018/00523 ,  A61B2018/00553 ,  A61B2018/00559 ,  A61B2018/00791 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1273 ,  A61B2018/1425 ,  A61B2018/1467 ,  A61B2018/1472 ,  A61B2090/3782 ,  A61B2218/002 ,  A61N1/06 ,  A61N1/403 ,  A61N7/02

    摘要： The invention provides improved devices, methods, and systems for shrinking of collagenated tissues, particularly for treating urinary incontinence in a noninvasive manner by directing energy to a patient's own support tissues. This energy heats fascia and other collagenated support tissues, causing them to contract. The energy can be applied intermittently, often between a pair of large plate electrodes having cooled flat electrode surfaces, the electrodes optionally being supported by a clamp structure. Such cooled plate electrodes are capable of directing electrical energy through an intermediate tissue and into fascia while the cooled electrode surface prevents injury to the intermediate tissue, particularly where the electrode surfaces are cooled before, during, and after an intermittent heating cycle. Ideally, the plate electrode comprises an electrode array including discrete electrode surface segments so that the current flux can be varied to selectively target the fascia. Alternatively, chilled “liquid electrodes” may direct current through a selected portion of the bladder (or other body cavity) while also cooling the bladder wall, an insulating gas can prevent heating of an alternative bladder portion and the adjacent tissues, and/or ultrasound transducers direct energy through an intermediate tissue and into fascia with little or no injury to the intermediate tissue. Cooled electrodes may be used to chill an intermediate engaged tissue so as to cause the maximum temperature difference between the target tissue and the intermediate tissue prior to initiating RF heating. This allows the dimensions of tissue reaching the treatment temperature to be controlled and/or minimized, the dimensions of protected intermediate tissue to be maximized, and the like.

    摘要翻译： 本发明提供了用于收缩胶原组织的改进的装置，方法和系统，特别是通过将能量引导到患者自己的支撑组织以非侵入性方式治疗尿失禁。 这种能量加热筋膜和其他胶原支持组织，导致它们收缩。 间歇地施加能量，通常在具有冷却的平坦电极表面的一对大平板电极之间，电极可选地由夹持结构支撑。 这样的冷却板电极能够将电能引导通过中间组织并进入筋膜，同时冷却的电极表面防止对中间组织的损伤，特别是在电极表面在间歇加热循环之前，期间和之后被冷却时。 理想地，平板电极包括包括分立电极表面段的电极阵列，使得可以改变电流通量以选择性地靶向仪表板。 或者，冷却的“液体电极”可以引导电流通过膀胱（或其他体腔）的选定部分，同时还冷却膀胱壁，绝缘气体可以防止替代膀胱部分和相邻组织和/或超声波的加热 换能器将能量通过中间组织直接导入筋膜，对中间组织几乎没有或没有损伤。 冷却的电极可用于冷却中间接合组织，以便在开始RF加热之前引起目标组织和中间组织之间的最大温差。 这允许控制和/或最小化达到治疗温度的组织的尺寸，被保护的中间组织的尺寸被最大化等等。

    Noninvasive devices, methods, and systems for shrinking of tissues
    6.
    发明授权
    Noninvasive devices, methods, and systems for shrinking of tissues 失效
    用于收缩组织的无创器件，方法和系统

    公开(公告)号：US06480746B1

    公开(公告)日：2002-11-12

    申请号：US08910775

    申请日：1997-08-13

    申请人： Frank Ingle ,  Garry L. Carter

    发明人： Frank Ingle ,  Garry L. Carter

    IPC分类号： A61N1818

    CPC分类号： A61B18/1485 ,  A61B18/1815 ,  A61B2017/00084 ,  A61B2017/003 ,  A61B2018/00011 ,  A61B2018/00023 ,  A61B2018/0016 ,  A61B2018/0022 ,  A61B2018/00517 ,  A61B2018/00523 ,  A61B2018/00791 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1273 ,  A61B2018/1467 ,  A61B2018/1472 ,  A61B2090/3782 ,  A61B2218/002 ,  A61N7/02

    摘要： The invention provides improved devices, methods, and systems for shrinking of collagenated tissues, particularly for treating urinary incontinence in a noninvasive manner by directing energy to a patient's own support tissues. This energy gently heats fascia and other collagenated support tissues, causing them to contract. The energy will preferably be applied between a pair of large plate electrodes having cooled flat electrode surfaces. Such cooled plate electrodes are capable of directing electrical energy through an intermediate tissue and into fascia while the cooled electrode surface prevents injury to the intermediate tissue. Ideally, the plate electrode comprises an electrode array including discrete electrode surface segments so that the current flux can be varied to selectively target the fascia.

    摘要翻译： 本发明提供了用于收缩胶原组织的改进的装置，方法和系统，特别是通过将能量引导到患者自己的支撑组织以非侵入性方式治疗尿失禁。 这种能量轻轻地加热筋膜和其他胶原支持组织，导致它们收缩。 能量将优选地施加在具有冷却的平坦电极表面的一对大板电极之间。 这样的冷却板电极能够将电能引导通过中间组织并进入筋膜，同时冷却的电极表面防止对中间组织的损伤。 理想地，平板电极包括包括分立电极表面段的电极阵列，使得可以改变电流通量以选择性地靶向仪表板。

    Tissue localizing and separating assembly
    7.
    发明授权
    Tissue localizing and separating assembly 失效
    组织定位和分离装配

    公开(公告)号：US07351211B2

    公开(公告)日：2008-04-01

    申请号：US11245625

    申请日：2005-10-07

    申请人： Eric L. Buehlmann ,  Lisanne A. Eng ,  Christine P. Ventura ,  Robert J. Laird ,  Frank Ingle

    发明人： Eric L. Buehlmann ,  Lisanne A. Eng ,  Christine P. Ventura ,  Robert J. Laird ,  Frank Ingle

    IPC分类号： A61B10/00 ,  A61B18/14

    CPC分类号： A61B18/148 ,  A61B18/1477 ,  A61B90/39 ,  A61B2018/1407 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2018/144 ,  A61B2090/3908

    摘要： A tissue separator assembly has an elongate tubular member and a tissue separator device located at a distal end of the elongate tubular member. An elongate coupler extends through the lumen of the elongate tubular member and has a distal coupler end. A tissue localization assembly has an elongate member and a localization device located at the distal end of the elongate member. The localization device may be movable from a first, radially-contracted state to a second, radially-expandable state. The distal coupler end of the elongate coupler and the proximal end of the elongate tubular member of the localization assembly are joinable to one another to permit docking of the tissue localization assembly to the tissue separator assembly. Methods of use of this device are also described.

    摘要翻译： 组织分离器组件具有细长的管状构件和位于细长管状构件的远端处的组织分离器装置。 细长联接器延伸穿过细长管状构件的内腔并且具有远端联接器端部。 组织定位组件具有细长构件和位于细长构件的远端处的定位装置。 定位装置可以从第一径向收缩状态移动到第二径向可扩张状态。 细长联接器的远端联接器端和定位组件的细长管状构件的近端可彼此连接，以允许组织定位组件对接组织分离器组件。 还描述了该装置的使用方法。

    Noninvasive devices, methods and systems for shrinking of tissues
    9.
    发明申请
    Noninvasive devices, methods and systems for shrinking of tissues 审中-公开
    用于收缩组织的无创器件，方法和系统

    公开(公告)号：US20050288680A1

    公开(公告)日：2005-12-29

    申请号：US11215156

    申请日：2005-08-29

    申请人： Frank Ingle ,  Garry Carter ,  Robert Laird ,  John Claude ,  Paul Do ,  Brian Mosel

    发明人： Frank Ingle ,  Garry Carter ,  Robert Laird ,  John Claude ,  Paul Do ,  Brian Mosel

    IPC分类号： A61B18/12 ,  A61B17/00 ,  A61B18/00 ,  A61B18/02 ,  A61B18/14 ,  A61N1/06 ,  A61N1/40 ,  A61B19/00

    CPC分类号： A61B18/1482 ,  A61B18/14 ,  A61B18/1477 ,  A61B18/1485 ,  A61B18/1815 ,  A61B2017/00084 ,  A61B2017/003 ,  A61B2018/00011 ,  A61B2018/00023 ,  A61B2018/00083 ,  A61B2018/00095 ,  A61B2018/00148 ,  A61B2018/0016 ,  A61B2018/0022 ,  A61B2018/00232 ,  A61B2018/00505 ,  A61B2018/00517 ,  A61B2018/00523 ,  A61B2018/00553 ,  A61B2018/00559 ,  A61B2018/00791 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1273 ,  A61B2018/1425 ,  A61B2018/1467 ,  A61B2018/1472 ,  A61B2090/3782 ,  A61B2218/002 ,  A61N1/06 ,  A61N1/403 ,  A61N7/02

    摘要： The invention provides improved devices, methods, and systems for shrinking of collagenated tissues, particularly for treating urinary incontinence in a noninvasive manner by directing energy to a patient's own support tissues. This energy heats fascia and other collagenated support tissues, causing them to contract. The energy can be applied intermittently, often between a pair of large plate electrodes having cooled flat electrode surfaces, the electrodes optionally being supported by a clamp structure. Such cooled plate electrodes are capable of directing electrical energy through an intermediate tissue and into fascia while the cooled electrode surface prevents injury to the intermediate tissue, particularly where the electrode surfaces are cooled before, during, and after an intermittent-heating cycle. Ideally, the plate electrode comprises an electrode array including discrete electrode surface segments so that the current flux can be varied to selectively target the fascia. Alternatively, chilled “liquid electrodes” may direct current through a selected portion of the bladder (or other body cavity) while also cooling the bladder wall, an insulating gas can prevent heating of an alternative bladder portion and the adjacent tissues, and/or ultrasound transducers direct energy through an intermediate tissue and into fascia with little or no injury to the intermediate tissue. Cooled electrodes may be used to chill an intermediate engaged tissue so as to cause the maximum temperature difference between the target tissue and the intermediate tissue prior to initiating RF heating. This allows the dimensions of tissue reaching the treatment temperature to be controlled and/or minimized, the dimensions of protected intermediate tissue to be maximized, and the like.

    摘要翻译： 本发明提供了用于收缩胶原组织的改进的装置，方法和系统，特别是通过将能量引导到患者自己的支撑组织以非侵入性方式治疗尿失禁。 这种能量加热筋膜和其他胶原支持组织，导致它们收缩。 间歇地施加能量，通常在具有冷却的平坦电极表面的一对大平板电极之间，电极可选地由夹持结构支撑。 这种冷却的平板电极能够将电能引导通过中间组织并进入筋膜，同时冷却的电极表面防止对中间组织的损伤，特别是在电极表面在间歇加热循环之前，期间和之后冷却。 理想地，平板电极包括包括分立电极表面段的电极阵列，使得可以改变电流通量以选择性地靶向仪表板。 或者，冷却的“液体电极”可以引导电流通过膀胱（或其他体腔）的选定部分，同时还冷却膀胱壁，绝缘气体可以防止替代膀胱部分和相邻组织和/或超声波的加热 换能器将能量通过中间组织直接导入筋膜，对中间组织几乎没有或没有损伤。 冷却的电极可用于冷却中间接合组织，以便在开始RF加热之前引起目标组织和中间组织之间的最大温差。 这允许控制和/或最小化达到治疗温度的组织的尺寸，被保护的中间组织的尺寸被最大化等等。

    Apparatus and methods for uniformly distributing coolant within a cryo-ablation device
    10.
    发明授权
    Apparatus and methods for uniformly distributing coolant within a cryo-ablation device 有权
    在冷冻消融装置内均匀分配冷却剂的装置和方法

    公开(公告)号：US08469919B2

    公开(公告)日：2013-06-25

    申请号：US12388399

    申请日：2009-02-18

    申请人： Frank Ingle ,  Raphael Hon

    发明人： Frank Ingle ,  Raphael Hon

    IPC分类号： A61B18/18

    CPC分类号： A61B18/02 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262

    摘要： Apparatus and methods for uniformly distributing coolant within a cryo-ablation device. A nozzle apparatus includes a tubular member having a plurality of angled apertures that induce swirling of coolant streams dispersed through the angled apertures. Coolant swirling round the tubular member and along an inner surface of an inflatable balloon element inflates the balloon element and cryogenically ablate tissue. The swirling action achieved using angled apertures uniformly distributes coolant along the inner surface of the balloon such that the temperatures along an inner surface of the balloon element and ablation of tissue adjacent to the balloon element are substantially uniform.

    摘要翻译： 在冷冻消融装置内均匀分配冷却剂的装置和方法。 喷嘴装置包括管状构件，其具有多个成角度的孔，其引导分散通过倾斜孔的冷却剂流的旋转。 冷却液在管状构件周围旋转并且沿着可充气球囊元件的内表面膨胀，从而使球囊元件膨胀并且低温地烧蚀组织。 使用角度孔使得的旋转动作沿着球囊的内表面均匀地分布冷却剂，使得沿着球囊元件的内表面的温度和与球囊元件相邻的组织的消融基本上是均匀的。