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公开(公告)号：US5376632A
公开(公告)日：1994-12-27
申请号：US906780
申请日：1992-06-30
CPC分类号： B82Y5/00 , A61K38/1816 , A61K47/48969 , Y10S514/814
摘要： The present invention relates to a new pharmaceutical composition for parenteral and local administration comprising an aqueous solution of erythropoietin and a .beta.- or .gamma.-cyclodextrin hydroxyalkyl derivative. The invention also relates to novel lyophilized or spray-dried erythropoietin compositions comprising a .beta.- or .gamma.-cyclodextrin hydroxyalkyl derivative, to processes for preparing such aqueous, lyophilized or spray-dried compositions and to a method for simultaneously stabilizing erythropoietin in an aqueous solution and preventing it from being adsorbed to surfaces.
摘要翻译： 本发明涉及用于胃肠外和局部给药的新型药物组合物，其包含促红细胞生成素的水溶液和β-或γ-环糊精羟烷基衍生物。 本发明还涉及包含β-或γ-环糊精羟烷基衍生物的新型冻干或喷雾干燥的促红细胞生成素组合物，用于制备这种水性，冻干或喷雾干燥的组合物的方法以及在水溶液中同时稳定促红细胞生成素的方法， 防止其吸附在表面上。
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公开(公告)号：US5491098A
公开(公告)日：1996-02-13
申请号：US231948
申请日：1994-04-21
IPC分类号： G01N33/532 , G01N33/553 , G01N33/58 , G03C5/58
CPC分类号： G03C5/58 , G01N33/532 , G01N33/553 , G01N33/585
摘要： An improved method for depositing metal particles on a marker which catalyzes the reduction of metal ions from a physical developer comprising a solution of metal ions, a molar excess of complexant in respect to the metal ions and a reducing agent. Said method being preferably employed for the detection of one or more components of an aggregate formed between a least one specific binding agent and its corresponding bindable substance by labelling at least one component of said aggregate with a marker and contacting said aggregate with a physical developer, whereby under influence of the marker a metal particle is formed which can be detected. Further the invention also relates to solutions and test-kits adapted for carrying out the above mentioned method.
摘要翻译： 一种用于在标记上沉积金属颗粒的改进方法，该方法催化从物理显影剂中还原金属离子，所述物理显影剂包含金属离子溶液，相对于金属离子摩尔过量的络合物和还原剂。 所述方法优选用于通过用标记物标记所述骨料的至少一种组分并将所述聚集体与物理显影剂接触来检测形成在至少一种特异性结合剂和其相应的可结合物质之间的聚集体的一种或多种组分， 由此在标记的影响下形成可以检测到的金属颗粒。 此外，本发明还涉及适于实施上述方法的溶液和试剂盒。
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公开(公告)号：US4837168A
公开(公告)日：1989-06-06
申请号：US941446
申请日：1986-12-15
IPC分类号： G01N33/545 , G01N33/543 , G01N33/546 , G01N33/564 , G01N33/569 , G01N33/58
CPC分类号： G01N33/54313 , G01N33/585 , Y10S436/80 , Y10S436/805 , Y10S436/808 , Y10S436/823 , Y10T428/2991
摘要： New method for the detection of specific binding agents and their corresponding bindable substances by employing a label which is a latex particle which can be visually detected.
摘要翻译： 通过使用可以被目视检测的胶乳颗粒的标签来检测特异性结合剂及其相应的可结合物质的新方法。
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公开(公告)号：US5681755A
公开(公告)日：1997-10-28
申请号：US467656
申请日：1995-06-06
IPC分类号： G01N33/532 , G01N33/553 , G01N33/58 , G03C5/58 , G01N33/533 , G03C5/30
CPC分类号： G03C5/58 , G01N33/532 , G01N33/553 , G01N33/585
摘要： An improved method for depositing metal particles on a marker which catalyzes the reduction of metal ions from a physical developer comprising a solution of metal ions, a molar excess of complexant in respect to the metal ions and a reducing agent. Said method being preferably employed for the detection of one or more components of an aggregate formed between a least one specific binding agent and its corresponding bindable substance by labelling at least one component of said aggregate with a marker and contacting said aggregate with a physical developer, whereby under influence of the marker a metal particle is formed which can be detected. Further the invention also relates to solutions and test-kits adapted for carrying out the above mentioned method.
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公开(公告)号：US5674755A
公开(公告)日：1997-10-07
申请号：US467655
申请日：1995-06-06
IPC分类号： G01N33/532 , G01N33/553 , G01N33/58 , G03C5/58 , G01N33/533 , G03C5/30
CPC分类号： G03C5/58 , G01N33/532 , G01N33/553 , G01N33/585
摘要： An improved method for depositing metal particles on a marker which catalyzes the reduction of metal ions from a physical developer comprising a solution of metal ions, a molar excess of complexant in respect to the metal ions and a reducing agent. Said method being preferably employed for the detection of one or more components of an aggregate formed between a least one specific binding agent and its corresponding bindable substance by labelling at least one component of said aggregate with a marker and contacting said aggregate with a physical developer, whereby under influence of the marker a metal particle is formed which can be detected. Further the invention also relates to solutions and test-kits adapted for carrying out the above mentioned method.
摘要翻译： 一种用于在标记上沉积金属颗粒的改进方法，该方法催化从物理显影剂中还原金属离子，所述物理显影剂包括金属离子溶液，相对于金属离子摩尔过量的络合物和还原剂。 所述方法优选用于通过用标记物标记所述骨料的至少一种组分并将所述聚集体与物理显影剂接触来检测形成在至少一种特异性结合剂和其相应的可结合物质之间的聚集体的一种或多种组分， 由此在标记的影响下形成可以检测到的金属颗粒。 此外，本发明还涉及适于实施上述方法的溶液和试剂盒。
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6.发明授权Method for the detection of specific binding agents and their corresponding bindable substances 失效用于检测特异性结合剂及其相应的可结合物质的方法
公开(公告)号：US5498551A
公开(公告)日：1996-03-12
申请号：US243425
申请日：1994-05-16
IPC分类号： G01N33/545 , G01N33/543 , G01N33/546 , G01N33/564 , G01N33/569 , G01N33/58
CPC分类号： G01N33/54313 , G01N33/585 , Y10S436/80 , Y10S436/805 , Y10S436/808 , Y10S436/823 , Y10T428/2991
摘要： New method for the detection of specific binding agents and their corresponding bindable substances by employing a label which is a latex particle which can be visually detected.
摘要翻译： 通过使用可以被目视检测的胶乳颗粒的标签来检测特异性结合剂及其相应的可结合物质的新方法。
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公开(公告)号：US5206122A
公开(公告)日：1993-04-27
申请号：US662586
申请日：1991-02-28
CPC分类号： G01N33/585 , G03C5/58
摘要： A light-stable physical developer comprising a solution of silver ions, a desensitizing agent and a reducing agent. A method for the detection of one or more components of an aggregate formed between at least one specific binding agent and its corresponding bindable substance by labelling at least one component of said aggregate with a marker and contacting said aggregate with said light-stable physical developer, whereby under influence of the marker a metal particle is formed which can be detected. Further the invention also relates to products, e.g. a test-kit adapted for carrying out the above mentioned method.
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公开(公告)号：US5441896A
公开(公告)日：1995-08-15
申请号：US73961
申请日：1993-06-08
IPC分类号： G01N33/543 , G01N33/553 , G01N33/58 , G01N21/77 , G01N33/537
CPC分类号： G01N33/585 , G01N33/54366 , Y10S435/805 , Y10S435/81 , Y10S435/962 , Y10S435/975 , Y10S436/805 , Y10S436/808 , Y10S436/81 , Y10S436/826 , Y10T436/25375 , Y10T436/255
摘要： The present invention is directed to a new assay procedure and improved solid phase assay devices for use with a so-called physical developer. The invention provides a new assay procedure for detecting the presence of an analyte in a fluid sample using a tracer having a metal label which signal is enhanced by applying a physical developer. The assay is performed with a device having a support for a test area and having attached thereto a binder specific for the analyte to be detected. The assay comprises the steps of directing the fluid sample and the tracer through a porous medium into contact with the test area at a controlled flow rate to allow binding of the analyte with the binder and the tracer to the analyte, directing a physical developer through said porous medium to amplify the signal generated by the tracer, and separating the device to allow the test area to be read. The invention further relates to devices and immunoassay test kits for carrying out the improved immunoassay procedure. A first device FIG. 2 according to the present invention has a support 4 having upper and lower surfaces and a test area on its upper surface. A removable filter 3 overlies the upper surface of the support. A second device FIG. 1 according to the present invention has a support 4 having upper and lower surfaces and a test area on its lower surface which is in contact with the absorptive layer 2.
摘要翻译： 本发明涉及用于所谓的物理显影剂的新的测定程序和改进的固相测定装置。 本发明提供了一种新的测定程序，用于使用具有金属标记的示踪剂来检测流体样品中分析物的存在，该信号通过施加物理显影剂得到增强。 使用具有对测试区域的支持并且附着有待检测分析物的粘合剂的装置进行测定。 该测定包括以下流程的步骤：引导流体样品和示踪剂通过多孔介质以受控的流速与测试区域接触，以使分析物与粘合剂和示踪剂结合到分析物上，引导物理显影剂通过所述 多孔介质以放大由示踪剂产生的信号，并分离该装置以允许读取测试区域。 本发明还涉及用于进行改进的免疫测定方法的装置和免疫测定试剂盒。 第一装置 根据本发明，图2所示的支架4具有上表面和下表面的支撑件4及其上表面上的测试区域。 可移动过滤器3覆盖在支撑件的上表面上。 第二装置 如图1所示，具有上下表面的支撑体4和与吸收层2接触的下表面的测试区域。
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