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1.发明申请APPARATUS AND METHOD FOR CHILLING CRYO-ABLATION COOLANT AND RESULTING CRYO-ABLATION SYSTEM 有权冷冻消融冷却剂和结晶洗涤系统的设备和方法公开(公告)号：US20090281533A1
公开(公告)日：2009-11-12
申请号：US12432465
申请日：2009-04-29
申请人： Frank W. Ingle , Leonard George , Raphael Hon , Joann Heberer
发明人： Frank W. Ingle , Leonard George , Raphael Hon , Joann Heberer
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/22051 , A61B2018/00166 , A61B2018/00172 , A61B2018/0022 , A61B2018/00577 , A61B2018/0212 , A61B2018/0262
摘要： Apparatus and methods for cooling liquid coolant, such as nitrous oxide, to be delivered to a cryo-ablation device such as a balloon catheter. A hose or conduit in fluid communication with the ablation device includes an outer member and inner tubes. A first inner tube disposed within a lumen of the outer member carries liquid coolant to the ablation device. Another inner tube also disposed within the lumen carries liquid coolant and terminates within the lumen such that gaseous coolant derived from liquid coolant flowing through the second inner tube flows within the lumen to cool or chill the first inner tube and liquid coolant carried by the first inner tube to the ablation device.
摘要翻译： 用于冷却诸如一氧化二氮的液体冷却剂的装置和方法将被输送到诸如球囊导管的低温消融装置。 与消融装置流体连通的软管或导管包括外部构件和内部管。 设置在外部构件的内腔内的第一内管将液体冷却剂携带到消融装置。 还设置在内腔内的另一内管承载液体冷却剂并且终止在内腔内，使得源自流过第二内管的液体冷却剂的气态冷却剂在管腔内流动以冷却或冷却第一内管和由第一内管 管到消融装置。
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2.发明授权Apparatus and method for chilling cryo-ablation coolant and resulting cryo-ablation system 有权用于冷冻冷冻消融冷却剂和产生的冷冻消融系统的装置和方法公开(公告)号：US09028445B2
公开(公告)日：2015-05-12
申请号：US12432465
申请日：2009-04-29
申请人： Frank W. Ingle , Leonard George , Raphael Hon , Joann Heberer
发明人： Frank W. Ingle , Leonard George , Raphael Hon , Joann Heberer
CPC分类号： A61B18/02 , A61B2017/22051 , A61B2018/00166 , A61B2018/00172 , A61B2018/0022 , A61B2018/00577 , A61B2018/0212 , A61B2018/0262
摘要： Apparatus and methods for cooling liquid coolant, such as nitrous oxide, to be delivered to a cryo-ablation device such as a balloon catheter. A hose or conduit in fluid communication with the ablation device includes an outer member and inner tubes. A first inner tube disposed within a lumen of the outer member carries liquid coolant to the ablation device. Another inner tube also disposed within the lumen carries liquid coolant and terminates within the lumen such that gaseous coolant derived from liquid coolant flowing through the second inner tube flows within the lumen to cool or chill the first inner tube and liquid coolant carried by the first inner tube to the ablation device.
摘要翻译： 用于冷却诸如一氧化二氮的液体冷却剂的装置和方法将被输送到诸如球囊导管的低温消融装置。 与消融装置流体连通的软管或导管包括外部构件和内部管。 设置在外部构件的内腔内的第一内管将液体冷却剂携带到消融装置。 还设置在内腔内的另一内管承载液体冷却剂并且终止在内腔内，使得源自流过第二内管的液体冷却剂的气态冷却剂在管腔内流动以冷却或冷却第一内管和由第一内管 管到消融装置。
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公开(公告)号：US20100191231A1
公开(公告)日：2010-07-29
申请号：US12695268
申请日：2010-01-28
申请人： Joann Heberer
发明人： Joann Heberer
CPC分类号： A61M25/00 , A61B18/02 , A61B18/1492 , A61B90/11 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61M25/0138 , A61M25/0152 , A61M25/0662 , A61M2025/0681
摘要： A method of performing a catheter-based procedure can include introducing a delivery sheath inside a patient's body and advancing a secondary sheath through the delivery sheath, toward a treatment site inside the patient's body. The secondary sheath can be distinct from the delivery sheath, coaxial to the delivery sheath along at least a portion of a length of the delivery sheath, and can have a default linear shape that is substantially free of radial bias. The method can further include introducing a catheter through the delivery sheath and secondary sheath, to the treatment site, and performing a procedure at the treatment site with the catheter. Performing the procedure can include performing the procedure while maintaining at a relatively fixed position the secondary sheath.
摘要翻译： 执行基于导管的程序的方法可以包括将输送护套引入患者体内并将次级护套穿过输送护套推向患者体内的治疗部位。 辅助护套可以不同于输送护套，沿着输送护套的长度的至少一部分与输送护套同轴，并且可以具有基本上没有径向偏压的默认线性形状。 该方法还可以包括将导管穿过输送护套和次级护套引入治疗部位，并在导管的处理部位进行手术。 执行该过程可以包括执行该过程，同时保持在次级护套的相对固定位置。
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公开(公告)号：US07537598B2
公开(公告)日：2009-05-26
申请号：US11114932
申请日：2005-04-26
申请人： Niraj A. Shah , Joann Heberer
发明人： Niraj A. Shah , Joann Heberer
IPC分类号： A61F11/00
CPC分类号： A61F2/013 , A61F2/95 , A61F2/966 , A61F2002/018 , A61F2230/0006 , A61F2230/0076 , A61F2230/008 , A61F2230/0097 , A61M25/09
摘要： A sheath attached to a guide wire, a tubular shaft member slidable on the guide wire and a filtering assembly constricted within the sheath are movable in a vessel to a position distal to a lesion in the direction of fluid flow. The filtering assembly may be formed from a plurality of angularly spaced splines and a mesh disposed on the splines having properties of passing fluid in the vessel while blocking the passage of emboli in the fluid. The splines may be provided with shape memory for expanding against the wall of the vessel when released from constriction by the sheath. The sheath may be moved relative to the filtering assembly and the support member to release the filter for expansion against the vessel wall. An interventional device can be used to treat the lesion. Any emboli released into the vessel as a result of the interventional treatment are blocked by the filter member while fluid is allowed to pass there through.
摘要翻译： 附接到导丝的护套，可在引导线上滑动的管状轴构件和在护套内收缩的过滤组件可在容器中沿流体流动方向移动到损伤远侧的位置。 过滤组件可以由多个角度间隔的花键形成，并且设置在花键上的网具有使流体在容器中通过的特性，同时阻止栓塞在流体中的通过。 花键可以设置有形状记忆，用于当从护套的收缩松开时抵靠容器的壁膨胀。 护套可以相对于过滤组件和支撑构件移动以释放过滤器用于膨胀抵靠血管壁。 可以使用介入装置来治疗病变。 由于介入治疗而释放到血管中的任何栓塞被过滤器构件堵塞，同时允许流体通过。
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5.发明申请公开(公告)号：US20100049184A1
公开(公告)日：2010-02-25
申请号：US12542978
申请日：2009-08-18
申请人： Leonard J. George , Joann Heberer
发明人： Leonard J. George , Joann Heberer
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/00017 , A61B2017/00539 , A61B2018/00023 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： A cryotherapy catheter can include an elongate member and an inflatable balloon at a distal end of the elongate member, the elongate member having lumens formed therein to supply cryogenic fluid to a chamber of the balloon and to channel exhaust from the balloon chamber; and a controller programmed to control a first rate at which the cryogenic fluid is supplied to the balloon chamber and a second rate at which exhaust is channeled from the balloon chamber, wherein the controller is programmed to a) develop, during a first phase of a cryotherapy procedure, a first pressure inside the balloon chamber at a value that is greater than an ambient pressure outside and adjacent to a proximal end of the elongate member, and b) develop, during a second phase of the cryotherapy procedure, the first pressure at a value that is less than the ambient pressure.
摘要翻译： 冷冻治疗导管可以包括在细长构件的远端处的细长构件和可膨胀气囊，细长构件具有形成在其中的腔，以将低温流体供应到球囊的腔室并且引导气囊腔排出; 以及控制器，其被编程为控制所述低温流体被供应到所述球囊腔室的第一速率以及从所述气囊腔室引导排气的第二速率，其中所述控制器被编程为a）在第一阶段期间， 冷冻治疗程序，气囊腔内的第一压力的值大于在细长构件的近端外部和邻近的环境压力，以及b）在冷冻治疗过程的第二阶段期间，将第一压力 一个小于环境压力的值。
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公开(公告)号：US06344045B1
公开(公告)日：2002-02-05
申请号：US09642961
申请日：2000-08-17
IPC分类号： A61F1100
CPC分类号： A61L29/049 , A61F2/958 , A61M25/1027 , A61M25/104 , A61M29/02 , B29C47/00 , B29C47/0023 , B29C47/065 , B29C55/24 , B29K2075/00 , B29L2022/022 , B29L2031/7542
摘要： The present invention is directed to a gauging system and method for using the same for determining the size of a lesion within a patient's body prior to stenting the lesion. In one embodiment the gauging system includes a catheter having an elongated shaft with proximal and distal ends, and an outer sheath formed of a compliant material and disposed about at least a portion of the catheter elongated shaft and being slidable over the same. In another embodiment, the gauging system further includes a radially expandable member formed of the same or different compliant material mounted on a distal section of the shaft and has an interior chamber in fluid communication with an inflation lumen extending within at least a portion of a distal shaft section to a location spaced proximally from the shaft distal end.
摘要翻译： 本发明涉及一种测量系统和方法，用于在支架植入病变之前确定患者体内损伤的尺寸。 在一个实施例中，测量系统包括具有细长轴的导管，其具有近端和远端，以及由柔性材料形成并且围绕导管细长轴的至少一部分设置并可在其上滑动的外护套。 在另一个实施例中，测量系统还包括由安装在轴的远侧部分上的相同或不同顺应性材料形成的径向可扩张构件，并且具有与膨胀腔流体连通的内部腔室，所述内部腔室在至少一部分远端 轴部分到距离轴远端近近距离的位置。
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公开(公告)号：US20090326526A1
公开(公告)日：2009-12-31
申请号：US12459032
申请日：2009-06-26
申请人： Frank Ingle , Joann Heberer
发明人： Frank Ingle , Joann Heberer
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B1/2275 , A61B18/0218 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2090/064
摘要： A method, system, and device for detecting whether an expandable member completely occludes an anatomic passageway allows a user, such as a physician, clinician, or surgeon, to perform a medical procedure more efficiently and increases the procedure's chances of success. An incomplete occlusion can be immediately detected by monitoring the pressure difference across the expandable member. Through this method, a user can quickly diagnose the problem and reposition the expandable member in the anatomic passageway. In particular, in a cryoablation procedure, devices incorporating this method can help ensure a uniform and complete lesion in the pulmonary vein to electrically isolate the pulmonary vein from the atrium, thus preventing atrial fibrillation.
摘要翻译： 用于检测可扩张构件是否完全遮蔽解剖通道的方法，系统和装置允许诸如医师，临床医师或外科医生之类的使用者更有效地执行医疗程序，并且增加程序的成功机会。 可以通过监测可膨胀构件上的压力差来立即检测到不完全闭塞。 通过这种方法，用户可以快速诊断问题，并将可扩展构件重新定位在解剖通道中。 特别地，在冷冻消融过程中，结合该方法的装置可以帮助确保肺静脉中的均匀和完整的损伤以将肺静脉与心房电隔离，从而防止心房颤动。
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公开(公告)号：US06964670B1
公开(公告)日：2005-11-15
申请号：US09615157
申请日：2000-07-13
申请人： Niraj A. Shah , Joann Heberer
发明人： Niraj A. Shah , Joann Heberer
CPC分类号： A61F2/013 , A61F2/95 , A61F2/966 , A61F2002/018 , A61F2230/0006 , A61F2230/0076 , A61F2230/008 , A61F2230/0097 , A61M25/09
摘要： A sheath attached to a guide wire, a tubular shaft member slidable on the guide wire and a filtering assembly constricted within the sheath are movable in a vessel to a position distal to a lesion in the direction of fluid flow. The filtering assembly may be formed from a plurality of angularly spaced splines and a mesh disposed on the splines having properties of passing fluid in the vessel while blocking the passage of emboli in the fluid. The splines may be provided with shape memory for expanding against the wall of the vessel when released from constriction by the sheath. The sheath may be moved relative to the filtering assembly and the support member to release the filter for expansion against the vessel wall. An interventional device can be used to treat the lesion. Any emboli released into the vessel as a result of the interventional treatment are blocked by the filter member while fluid is allowed to pass there through.
摘要翻译： 附接到导丝的护套，可在引导线上滑动的管状轴构件和在护套内收缩的过滤组件可在容器中沿流体流动方向移动到损伤远侧的位置。 过滤组件可以由多个角度间隔的花键形成，并且设置在花键上的网具有使流体在容器中通过的特性，同时阻止栓塞在流体中的通过。 花键可以设置有形状记忆，用于当从护套的收缩松开时抵靠容器的壁膨胀。 护套可以相对于过滤组件和支撑构件移动以释放过滤器用于膨胀抵靠血管壁。 可以使用介入装置来治疗病变。 由于介入治疗而释放到血管中的任何栓塞被过滤器构件堵塞，同时允许流体通过。
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9.发明授权公开(公告)号：US08845627B2
公开(公告)日：2014-09-30
申请号：US12542978
申请日：2009-08-18
申请人： Leonard J. George , Joann Heberer
发明人： Leonard J. George , Joann Heberer
CPC分类号： A61B18/02 , A61B2017/00017 , A61B2017/00539 , A61B2018/00023 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： A cryotherapy catheter can include an elongate member and an inflatable balloon at a distal end of the elongate member, the elongate member having lumens formed therein to supply cryogenic fluid to a chamber of the balloon and to channel exhaust from the balloon chamber; and a controller programmed to control a first rate at which the cryogenic fluid is supplied to the balloon chamber and a second rate at which exhaust is channeled from the balloon chamber, wherein the controller is programmed to a) develop, during a first phase of a cryotherapy procedure, a first pressure inside the balloon chamber at a value that is greater than an ambient pressure outside and adjacent to a proximal end of the elongate member, and b) develop, during a second phase of the cryotherapy procedure, the first pressure at a value that is less than the ambient pressure.
摘要翻译： 冷冻治疗导管可以包括在细长构件的远端处的细长构件和可膨胀气囊，细长构件具有形成在其中的腔，以将低温流体供应到球囊的腔室并且引导气囊腔排出; 以及控制器，其被编程为控制所述低温流体被供应到所述球囊腔室的第一速率以及从所述气囊腔室引导排气的第二速率，其中所述控制器被编程为a）在第一阶段期间， 冷冻治疗程序，气囊腔内的第一压力的值大于在细长构件的近端外部和邻近的环境压力，以及b）在冷冻治疗过程的第二阶段期间，将第一压力 一个小于环境压力的值。
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公开(公告)号：US08821485B2
公开(公告)日：2014-09-02
申请号：US12695268
申请日：2010-01-28
申请人： Joann Heberer
发明人： Joann Heberer
IPC分类号： A61B18/02 , A61B18/12 , A61M25/00 , A61M25/06 , A61B18/14 , A61B19/00 , A61M25/01 , A61B18/00
CPC分类号： A61M25/00 , A61B18/02 , A61B18/1492 , A61B90/11 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61M25/0138 , A61M25/0152 , A61M25/0662 , A61M2025/0681
摘要： A method of performing a catheter-based procedure can include introducing a delivery sheath inside a patient's body and advancing a secondary sheath through the delivery sheath, toward a treatment site inside the patient's body. The secondary sheath can be distinct from the delivery sheath, coaxial to the delivery sheath along at least a portion of a length of the delivery sheath, and can have a default linear shape that is substantially free of radial bias. The method can further include introducing a catheter through the delivery sheath and secondary sheath, to the treatment site, and performing a procedure at the treatment site with the catheter. Performing the procedure can include performing the procedure while maintaining at a relatively fixed position the secondary sheath.
摘要翻译： 执行基于导管的程序的方法可以包括将输送护套引入患者体内并将次级护套穿过输送护套推向患者体内的治疗部位。 辅助护套可以不同于输送护套，沿着输送护套的长度的至少一部分与输送护套同轴，并且可以具有基本上没有径向偏压的默认线性形状。 该方法还可以包括将导管穿过输送护套和次级护套引入治疗部位，并在导管的处理部位进行手术。 执行该过程可以包括执行该过程，同时保持在次级护套的相对固定位置。
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