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公开(公告)号：US5554121A
公开(公告)日：1996-09-10
申请号：US280210
申请日：1994-07-25
CPC分类号： A61M25/104 , A61L29/06 , A61L29/14 , A61M25/0054 , A61M25/0045
摘要： A balloon dilatation having a relatively stiff proximal catheter shaft which is formed at least in part of an engineering thermoplastic polymer material with a tensile strength of at least about 10,000 psi, an elongation of at least 50% and a tensile modulus of at least 300,000 psi. The polymer is preferably an aromatic polymer, and particularly polyetheretherketone.
摘要翻译： 具有相对刚性的近端导管轴的球囊扩张，其至少部分地由至少约10,000psi的拉伸强度，至少50％的伸长率和至少300,000psi的拉伸模量形成在工程热塑性聚合物材料中 。 聚合物优选为芳族聚合物，特别是聚醚醚酮。
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公开(公告)号：US07842012B2
公开(公告)日：2010-11-30
申请号：US11346771
申请日：2006-02-03
申请人： Jeffrey T. Ellis , Robert D. Ainsworth , Deborah L. Kilpatrick , Alex Q. Tilson , Bridget A. Hurley
发明人： Jeffrey T. Ellis , Robert D. Ainsworth , Deborah L. Kilpatrick , Alex Q. Tilson , Bridget A. Hurley
CPC分类号： A61B5/14542 , A61B5/14552 , A61B5/1459 , A61B5/6851
摘要： A guidewire with a sensor which can detect NO and/or superoxide levels is disclosed. This invention can be useful for in vivo analysis of vascular health.
摘要翻译： 公开了一种具有可检测NO和/或超氧化物浓度的传感器的导丝。 本发明可用于血管健康的体内分析。
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公开(公告)号：US20090326574A1
公开(公告)日：2009-12-31
申请号：US12486639
申请日：2009-06-17
CPC分类号： A61F2/958 , A61B2017/22081
摘要： A method of treating vulnerable plaque comprising intentionally damaging or rupturing the vulnerable plaque using a wingless balloon which is inflated from a wingless unexpanded diameter to a limited expanded diameter. This process produces significant increase in ECM synthesis at the site of the damage or rupture. As a result, the method strengthens the vulnerable plaque while minimizing or avoiding damage to the surrounding wall of the body lumen or damaging a stable plaque mistakenly believed to be a vulnerable plaque. The method of the invention is particularly useful in treating a fibroatheroma type of vulnerable plaque. In one embodiment, the balloon is self-limiting such that it expands compliantly at initial inflation pressures, and above nominal pressure it expands noncompliantly. In an alternative embodiment, the balloon is inflated using a diameter-limiting device, such as a device which limits the inflation pressure or the volume of inflation fluid in the balloon.
摘要翻译： 一种治疗易损斑块的方法，包括使用从无翅未膨胀直径膨胀至有限扩张直径的无翼气球故意破坏或破裂易损斑块。 该过程在损伤或破裂部位产生ECM合成的显着增加。 因此，该方法可加强易损斑块，同时最大限度地减少或避免对体腔周围壁的损害或损坏被认为是易损斑块的稳定斑块。 本发明的方法特别可用于治疗纤维腺瘤型易损斑块。 在一个实施例中，气囊是自限制性的，使得其在初始充气压力下顺应地膨胀，并且在额定压力之上，其膨胀不顺利。 在替代实施例中，使用直径限制装置（例如限制气囊中的充气压力或膨胀流体的体积的装置）使球囊膨胀。
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公开(公告)号：US06972024B1
公开(公告)日：2005-12-06
申请号：US10032322
申请日：2001-12-21
CPC分类号： A61F2/958 , A61B2017/22081
摘要： A method of treating vulnerable plaque comprising intentionally damaging or rupturing the vulnerable plaque using a wingless balloon which is inflated from a wingless unexpanded diameter to a limited expanded diameter. This process produces significant increase in ECM synthesis at the site of the damage or rupture. As a result, the method strengthens the vulnerable plaque while minimizing or avoiding damage to the surrounding wall of the body lumen or damaging a stable plaque mistakenly believed to be a vulnerable plaque. The method of the invention is particularly useful in treating a fibroatheroma type of vulnerable plaque. In one embodiment, the balloon is self-limiting such that it expands compliantly at initial inflation pressures, and above nominal pressure it expands noncompliantly. In an alternative embodiment, the balloon is inflated using a diameter-limiting device, such as a device which limits the inflation pressure or the volume of inflation fluid in the balloon.
摘要翻译： 一种治疗易损斑块的方法，包括使用从无翅未膨胀直径膨胀至有限扩张直径的无翼气球故意破坏或破裂易损斑块。 该过程在损伤或破裂部位产生ECM合成的显着增加。 因此，该方法可加强易损斑块，同时最大限度地减少或避免对体腔周围壁的损害或损坏被认为是易损斑块的稳定斑块。 本发明的方法特别可用于治疗纤维腺瘤型易损斑块。 在一个实施例中，气囊是自限制性的，使得其在初始充气压力下顺应地膨胀，并且在额定压力之上，其膨胀不顺利。 在替代实施例中，使用直径限制装置（例如限制气囊中的充气压力或膨胀流体的体积的装置）使球囊膨胀。
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公开(公告)号：US5451209A
公开(公告)日：1995-09-19
申请号：US198181
申请日：1994-02-16
CPC分类号： A61M25/104 , A61M25/005 , A61M2025/0183 , A61M2025/1093
摘要： A composite tubular element for intravascular catheters, such as fixed-wire dilatation catheters and guiding and angiographic catheters, which is formed by braiding strands formed from an intimate mixture of polymeric matrix materials, such as fibers and powders, having a relatively low melting point and high strength reinforcing fibers having a relatively high melting point into a tubular element, heating the braided tubular element to melt the low melting point matrix materials and flow around the reinforcing fibers to form a matrix. A thermoplastic jacket or coating may then be extruded or otherwise applied to the exterior of the braided tubular element.
摘要翻译： 用于血管内导管的复合管状元件，例如固定丝扩张导管和引导和血管造影导管，其通过编织由诸如纤维和粉末的聚合物基质材料（诸如纤维和粉末）的相当低熔点的紧密混合物形成的线形成， 将具有较高熔点的高强度增强纤维加入到管状元件中，加热编织管状元件以熔化低熔点基体材料并在增强纤维周围流动以形成基体。 然后可以将热塑性护套或涂层挤出或以其它方式施加到编织管状元件的外部。
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公开(公告)号：US07553292B2
公开(公告)日：2009-06-30
申请号：US11140240
申请日：2005-05-26
IPC分类号： A61M29/00
CPC分类号： A61F2/958 , A61B2017/22081
摘要： A method of treating vulnerable plaque comprising intentionally damaging or rupturing the vulnerable plaque using a wingless balloon which is inflated from a wingless unexpanded diameter to a limited expanded diameter. This process produces significant increase in ECM synthesis at the site of the damage or rupture. As a result, the method strengthens the vulnerable plaque while minimizing or avoiding damage to the surrounding wall of the body lumen or damaging a stable plaque mistakenly believed to be a vulnerable plaque. The method of the invention is particularly useful in treating a fibroatheroma type of vulnerable plaque. In one embodiment, the balloon is self-limiting such that it expands compliantly at initial inflation pressures, and above nominal pressure it expands noncompliantly. In an alternative embodiment, the balloon is inflated using a diameter-limiting device, such as a device which limits the inflation pressure or the volume of inflation fluid in the balloon.
摘要翻译： 一种治疗易损斑块的方法，包括使用从无翅未膨胀直径膨胀至有限扩张直径的无翼气球故意破坏或破裂易损斑块。 该过程在损伤或破裂部位产生ECM合成的显着增加。 因此，该方法可加强易损斑块，同时最大限度地减少或避免对体腔周围壁的损害或损坏被认为是易损斑块的稳定斑块。 本发明的方法特别可用于治疗纤维腺瘤型易损斑块。 在一个实施例中，气囊是自限制性的，使得其在初始充气压力下顺应地膨胀，并且在额定压力之上，其膨胀不顺利。 在替代实施例中，使用直径限制装置（例如限制气囊中的充气压力或膨胀流体的体积的装置）使球囊膨胀。
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公开(公告)号：US20080139897A1
公开(公告)日：2008-06-12
申请号：US12008381
申请日：2008-01-09
CPC分类号： A61B5/0084 , A61B5/0086 , A61B5/02007 , A61B5/02154 , A61B5/1459 , A61B5/6853 , A61B2017/22001
摘要： An apparatus and method to perform therapeutic treatment and diagnosis of a patient's vasculature through the use of an intravascular device having an optical fiber disposed therein. In an embodiment, the apparatus includes an intravascular device to perform a therapeutic treatment and at least one optical fiber disposed through the intravascular device. The optical fiber is configured to provide diagnostic information before, during, and after the therapeutic treatment. In an embodiment, diagnostic information includes vessel and blood characteristics such as hemodynamic characteristics, hematological parameters related to blood and blood components, and thermal parameters of the vasculature.
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8.发明授权公开(公告)号：US07364657B2
公开(公告)日：2008-04-29
申请号：US11097022
申请日：2005-03-31
申请人： Evgenia Mandrusov , Albert K. Chin , William Earl Webler, Jr. , Yan Shen , Robert D. Ainsworth , Eugene Michel
发明人： Evgenia Mandrusov , Albert K. Chin , William Earl Webler, Jr. , Yan Shen , Robert D. Ainsworth , Eugene Michel
IPC分类号： B01D36/00 , B01D21/26 , B01D21/32 , B01D33/00 , B01D33/70 , B01D37/00 , B04B1/02 , B04B11/00 , B04B13/00
CPC分类号： A61B17/3472 , A61B1/015 , A61B1/313 , A61B2017/00969 , A61B2217/005 , A61K35/28 , A61K2035/124 , A61M5/00 , A61M2202/10 , A61M2210/02 , A61M2210/125
摘要： Numerous embodiments of a system and method for treating cardiac tissue are described. In one embodiment, bone marrow cells are extracted from a patient. The cells are then processed to isolate mononuclear cells, which can then be delivered back near the cardiac tissue of the patient.
摘要翻译： 描述了用于治疗心脏组织的系统和方法的许多实施例。 在一个实施方案中，从患者中提取骨髓细胞。 然后处理细胞以分离单核细胞，其然后可以在患者的心脏组织附近被递送回来。
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公开(公告)号：US07241257B1
公开(公告)日：2007-07-10
申请号：US10184868
申请日：2002-06-28
申请人： Robert D. Ainsworth , Hongzhi Bai , Greg Hyde
发明人： Robert D. Ainsworth , Hongzhi Bai , Greg Hyde
IPC分类号： A61M1/10
CPC分类号： A61B17/00234 , A61B17/3207 , A61B2017/00243 , A61B2017/22054 , A61B2017/22069 , A61F2/013 , A61F2/2427 , A61M1/1008 , A61M1/101 , A61M1/1018 , A61M1/1029 , A61M1/1031 , A61M1/122 , A61M1/125 , A61M25/10
摘要： In one embodiment, there is disclosed a device adapted to be used for percutaneous minimally invasive heart surgery including a catheter having a proximal end and a distal end adapted to be fed through a blood vessel, a pump associated with the distal end of the catheter, and a tool associated with the distal end of the catheter. The tool is adapted to be used for percutaneous minimally invasive heart surgery. Examples of the tools include a tool for excising natural tissue, a tool for excising a natural valve, and anthretomy device, a prosthetic valve delivery system, a balloon catheter, a knife, a stapler, and a screwdriver. The pump is used for maintaining blood flow around the site of the heart surgery while the surgery is taking place without the use of cardiopulmonary bypass.
摘要翻译： 在一个实施例中，公开了一种适用于经皮微创心脏手术的装置，包括具有适于通过血管进给的近端和远端的导管，与导管的远端相关的泵， 以及与导管的远端相关联的工具。 该工具适用于经皮微创心脏手术。 这些工具的实例包括用于切除天然组织的工具，用于切除自然瓣膜的工具，以及手术装置，假体瓣膜输送系统，球囊导管，刀，吻合器和螺丝起子。 该泵用于在手术正在进行而不使用体外循环的情况下维持心脏手术现场周围的血液流动。
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公开(公告)号：US06761786B2
公开(公告)日：2004-07-13
申请号：US10165916
申请日：2002-06-10
IPC分类号： B29C4788
CPC分类号： A61L27/16 , A61L29/041 , C08L23/06 , C08L2207/068 , Y10T156/1038 , Y10T428/139
摘要： Medical devices such as catheter balloons, stent covers and vascular grafts formed of ultrahigh molecular weight polyethylene. The devices are formed from polyethylene that has been processed so that it is microporous and has an oriented node and fibril structure. The balloons expand compliantly at low strains and are substantially less compliant at higher strains. The invention also comprises methods for making such balloons, including the steps of compacting a polyethylene powder and deforming it to impart the oriented structure.
摘要翻译： 诸如导管球囊，支架盖和由超高分子量聚乙烯形成的血管移植物的医疗装置。 这些装置由聚乙烯形成，其已经被处理以使其是微孔的并且具有定向的节点和原纤维结构。 气球在低应变下柔顺扩张，并且在较高应变下基本上较不顺应。 本发明还包括制造这种气球的方法，包括压制聚乙烯粉末并变形以赋予定向结构的步骤。
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