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公开(公告)号：US07897170B2
公开(公告)日：2011-03-01
申请号：US11809459
申请日：2007-06-01
申请人： Frederick H. Strickler , Mark Boden
发明人： Frederick H. Strickler , Mark Boden
IPC分类号： A61F13/00
CPC分类号： A61L27/16 , A61L29/041 , A61L31/048 , C08L53/00
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided that contain at least one covalently crosslinked polymeric region, which contains at least one block copolymer comprising at least one low Tg block and at least one high Tg block.
摘要翻译： 根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含至少一个共价交联的聚合物区域，其含有至少一个包含至少一个低Tg嵌段和至少一个高Tg嵌段的嵌段共聚物。
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公开(公告)号：US20080051541A1
公开(公告)日：2008-02-28
申请号：US11809459
申请日：2007-06-01
申请人： Frederick H. Strickler , Mark Boden
发明人： Frederick H. Strickler , Mark Boden
CPC分类号： A61L27/16 , A61L29/041 , A61L31/048 , C08L53/00
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided that contain at least one covalently crosslinked polymeric region, which contains at least one block copolymer comprising at least one low Tg block and at least one high Tg block.
摘要翻译： 根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含至少一个共价交联的聚合物区域，其含有至少一个包含至少一个低Tg嵌段和至少一个高Tg嵌段的嵌段共聚物。
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3.发明授权公开(公告)号：US08911760B2
公开(公告)日：2014-12-16
申请号：US12650234
申请日：2009-12-30
申请人： Mark Boden , Marlene C. Schwarz , Frederick H. Strickler , Rudolf Faust , Umaprasana Ojha , Tomoya Higashihara
发明人： Mark Boden , Marlene C. Schwarz , Frederick H. Strickler , Rudolf Faust , Umaprasana Ojha , Tomoya Higashihara
IPC分类号： A61F13/00 , A61K31/74 , C08G63/91 , C08L67/00 , C08G79/02 , C08G63/02 , C08G63/08 , C08G64/00 , C08G64/18 , A61L27/16 , A61L27/54 , A61L27/58 , A61L29/04 , A61L29/14 , A61L29/16 , A61L31/04 , A61L31/14 , A61L31/16 , C08G18/42 , C08G18/62 , C08G18/76 , C08G63/00 , C08G63/06 , C08G64/42 , C08G69/08
CPC分类号： C08F299/04 , A61L27/165 , A61L27/54 , A61L27/58 , A61L29/041 , A61L29/148 , A61L29/16 , A61L31/048 , A61L31/148 , A61L31/16 , A61L2300/00 , C08G18/4266 , C08G18/6204 , C08G18/7671 , C08G63/00 , C08G63/06 , C08G63/912 , C08G64/18 , C08G64/42 , C08G69/08 , C08G2261/126 , C08L53/02
摘要： The present invention pertains to copolymers having one or more polyisobutylene segments and one or more biodegradable polymer segments, to methods of making such copolymers, to medical articles that contain such copolymers, and to methods of making such medical articles. According to certain aspects of the invention, copolymers are provided, which comprise a plurality of polyisobutylene segments and a plurality of biodegradable polymer segments. According to certain aspects of the invention, copolymers are provided, which comprise urethane linkages, urea linkages, amide linkages, ester linkages, anhydride linkages, carbonate linkages, linkages commonly described as “click” chemistry linkages, and combinations of two or more types of such linkages.
摘要翻译： 本发明涉及具有一个或多个聚异丁烯链段和一个或多个生物可降解聚合物链段的共聚物，制备这种共聚物的方法，含有这种共聚物的医药制品，以及制备这种医疗制品的方法。 根据本发明的某些方面，提供了包含多个聚异丁烯链段和多个可生物降解的聚合物链段的共聚物。 根据本发明的某些方面，提供了共聚物，其包含氨基甲酸酯键，脲键，酰胺键，酯键，酸酐键，碳酸酯键，通常描述为“点击”化学键的键，以及两种或更多种类型 这样的联系。
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4.发明授权Polyisobutylene urethane, urea and urethane/urea copolymers and medical devices containing the same 有权聚异丁烯聚氨酯，尿素和氨基甲酸酯/尿素共聚物以及含有它们的医疗装置公开(公告)号：US08501831B2
公开(公告)日：2013-08-06
申请号：US13618148
申请日：2012-09-14
申请人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
发明人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
IPC分类号： A61N1/05
CPC分类号： C08G18/6204 , A61L27/18 , A61L31/06 , C08G18/10 , C08G18/12 , C08G18/4063 , C08G18/4854 , C08G18/4858 , C08G18/6511 , C08G18/7657 , C08L75/00 , C08G18/3206
摘要： The present invention pertains to polyisobutylene urethane, urea and urethane/urea copolymers, to methods of making such copolymers and to medical devices that contain such polymers. According to certain aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment, an additional polymeric segment that is not a polyisobutylene segment, and a segment comprising a residue of a diisocyanate. According to other aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment and end groups that comprise alkyl-, alkenyl- or alkynyl-chain-containing end groups.
摘要翻译： 本发明涉及聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/尿素共聚物，涉及制备这种共聚物的方法和含有这种聚合物的医疗装置。 根据本发明的某些方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段，不是聚异丁烯链段的另外的聚合链段和包含二异氰酸酯残基的链段。 根据本发明的其它方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段和包含含有烷基，链烯基或炔基链的端基的端基。
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5.发明申请公开(公告)号：US20130013040A1
公开(公告)日：2013-01-10
申请号：US13618148
申请日：2012-09-14
申请人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
发明人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
CPC分类号： C08G18/6204 , A61L27/18 , A61L31/06 , C08G18/10 , C08G18/12 , C08G18/4063 , C08G18/4854 , C08G18/4858 , C08G18/6511 , C08G18/7657 , C08L75/00 , C08G18/3206
摘要： The present invention pertains to polyisobutylene urethane, urea and urethane/urea copolymers, to methods of making such copolymers and to medical devices that contain such polymers. According to certain aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment, an additional polymeric segment that is not a polyisobutylene segment, and a segment comprising a residue of a diisocyanate. According to other aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment and end groups that comprise alkyl-, alkenyl- or alkynyl-chain-containing end groups.
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6.发明申请POLYISOBUTYLENE URETHANE, UREA AND URETHANE/UREA COPOLYMERS AND MEDICAL DEVICES CONTAINING THE SAME 审中-公开聚异丁烯尿素，尿素和尿素/尿素共聚物和含有它的医疗装置公开(公告)号：US20090326077A1
公开(公告)日：2009-12-31
申请号：US12492440
申请日：2009-06-26
申请人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
发明人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
CPC分类号： C08G18/6204 , A61L27/18 , A61L31/06 , C08G18/10 , C08G18/12 , C08G18/4063 , C08G18/4854 , C08G18/4858 , C08G18/6511 , C08G18/7657 , C08L75/00 , C08G18/3206
摘要： The present invention pertains to polyisobutylene urethane, urea and urethane/urea copolymers, to methods of making such copolymers and to medical devices that contain such polymers. According to certain aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment, an additional polymeric segment that is not a polyisobutylene segment, and a segment comprising a residue of a diisocyanate. According to other aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment and end groups that comprise alkyl-, alkenyl- or alkynyl-chain-containing end groups.
摘要翻译： 本发明涉及聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/尿素共聚物，涉及制备这种共聚物的方法和含有这种聚合物的医疗装置。 根据本发明的某些方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段，不是聚异丁烯链段的另外的聚合链段和包含二异氰酸酯残基的链段。 根据本发明的其它方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段和包含含有烷基，链烯基或炔基链的端基的端基。
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公开(公告)号：US20090186067A1
公开(公告)日：2009-07-23
申请号：US12395276
申请日：2009-02-27
申请人： Frederick H. Strickler , Mark Boden
发明人： Frederick H. Strickler , Mark Boden
CPC分类号： A61L29/041 , A61L27/16 , A61L31/048 , C08L53/00
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided that contain at least one covalently crosslinked polymeric region, which contains at least one block copolymer comprising at least one low Tg block and at least one high Tg block.
摘要翻译： 根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含至少一个共价交联的聚合物区域，其含有至少一个包含至少一个低Tg嵌段和至少一个高Tg嵌段的嵌段共聚物。
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8.发明授权Polyisobutylene urethane, urea and urethane/urea copolymers and medical devices containing the same 有权聚异丁烯聚氨酯，尿素和氨基甲酸酯/尿素共聚物以及含有它们的医疗装置公开(公告)号：US08324290B2
公开(公告)日：2012-12-04
申请号：US12492483
申请日：2009-06-26
申请人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
发明人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
IPC分类号： A61N1/05
CPC分类号： C08G18/6204 , A61L27/18 , A61L31/06 , C08G18/10 , C08G18/12 , C08G18/4063 , C08G18/4854 , C08G18/4858 , C08G18/6511 , C08G18/7657 , C08L75/00 , C08G18/3206
摘要： The present invention pertains to polyisobutylene urethane, urea and urethane/urea copolymers, to methods of making such copolymers and to medical devices that contain such polymers. According to certain aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment, an additional polymeric segment that is not a polyisobutylene segment, and a segment comprising a residue of a diisocyanate. According to other aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment and end groups that comprise alkyl-, alkenyl- or alkynyl-chain-containing end groups.
摘要翻译： 本发明涉及聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/尿素共聚物，涉及制备这种共聚物的方法和含有这种聚合物的医疗装置。 根据本发明的某些方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段，不是聚异丁烯链段的另外的聚合链段和包含二异氰酸酯残基的链段。 根据本发明的其它方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段和包含含有烷基，链烯基或炔基链的端基的端基。
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9.发明授权Medical devices having polymeric regions based on styrene-isobutylene copolymers 有权具有基于苯乙烯 - 异丁烯共聚物的聚合物区域的医疗装置公开(公告)号：US07887830B2
公开(公告)日：2011-02-15
申请号：US12070806
申请日：2008-02-21
IPC分类号： A61F2/00
CPC分类号： A61L31/048 , A61L27/16 , A61L27/34 , A61L29/041 , A61L29/085 , A61L31/10 , C08L53/02
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions. These polymeric regions, in turn, contain one or more polymers, at least one of which is a copolymer that includes a styrene monomer and an isobutylene monomer. Moreover, the styrene monomer content of the copolymer typically ranges from 25 to 50 mol %.
摘要翻译： 根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含一个或多个聚合物区域。 这些聚合物区域又包含一种或多种聚合物，其中至少一种是包括苯乙烯单体和异丁烯单体的共聚物。 此外，共聚物的苯乙烯单体含量通常为25〜50摩尔％。
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10.发明申请公开(公告)号：US20100166820A1
公开(公告)日：2010-07-01
申请号：US12650234
申请日：2009-12-30
申请人： Mark Boden , Marlene C. Schwarz , Frederick H. Strickler , Rudolf Faust , Umaprasana Ojha , Tomoya Higashihara
发明人： Mark Boden , Marlene C. Schwarz , Frederick H. Strickler , Rudolf Faust , Umaprasana Ojha , Tomoya Higashihara
IPC分类号： A61K9/00 , C08G61/00 , C08G63/00 , C08G64/00 , C08G63/08 , C08G69/48 , C08G79/02 , C08G18/00
CPC分类号： C08F299/04 , A61L27/165 , A61L27/54 , A61L27/58 , A61L29/041 , A61L29/148 , A61L29/16 , A61L31/048 , A61L31/148 , A61L31/16 , A61L2300/00 , C08G18/4266 , C08G18/6204 , C08G18/7671 , C08G63/00 , C08G63/06 , C08G63/912 , C08G64/18 , C08G64/42 , C08G69/08 , C08G2261/126 , C08L53/02
摘要： The present invention pertains to copolymers having one or more polyisobutylene segments and one or more biodegradable polymer segments, to methods of making such copolymers, to medical articles that contain such copolymers, and to methods of making such medical articles. According to certain aspects of the invention, copolymers are provided, which comprise a plurality of polyisobutylene segments and a plurality of biodegradable polymer segments. According to certain aspects of the invention, copolymers are provided, which comprise urethane linkages, urea linkages, amide linkages, ester linkages, anhydride linkages, carbonate linkages, linkages commonly described as “click” chemistry linkages, and combinations of two or more types of such linkages.
摘要翻译： 本发明涉及具有一个或多个聚异丁烯链段和一个或多个生物可降解聚合物链段的共聚物，制备这种共聚物的方法，含有这种共聚物的医药制品以及制备这种医疗制品的方法。 根据本发明的某些方面，提供了包含多个聚异丁烯链段和多个可生物降解的聚合物链段的共聚物。 根据本发明的某些方面，提供了共聚物，其包含氨基甲酸酯键，脲键，酰胺键，酯键，酸酐键，碳酸酯键，通常描述为“点击”化学键的键，以及两种或更多种类型 这样的联系。
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