Carbazolyl-(4)-oxypropanolamine compounds and therapeutic compositions
    3.
    发明授权
    Carbazolyl-(4)-oxypropanolamine compounds and therapeutic compositions 失效
    (4) - 氧丙醇胺化合物和治疗组合物

    公开(公告)号:US4503067A

    公开(公告)日:1985-03-05

    申请号:US479921

    申请日:1983-04-04

    CPC分类号: C07D209/88 C07D317/64

    摘要: Carbazolyl-(4)-oxypropanolamine compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkanoyl or aroyl;R.sub.2 is hydrogen, lower alkyl or arylalkyl;R.sub.3 is hydrogen or lower alkyl;R.sub.4 is hydrogen or lower alkyl, or when X is oxygen, R.sub.4 together with R.sub.5 can represent --CH.sub.2 --O--;X is a valency bond, --CH.sub.2 --, oxygen or sulfur;Ar is mono- or bicyclic aryl or pyridyl;R.sub.5 and R.sub.6 are individually selected from hydrogen, halogen, hydroxyl, lower alkyl, aminocarbonyl, lower alkoxy, aralkyloxy, lower alkylthio, lower alkylsulphinyl or lower alkylsulphonyl;R.sub.5 and R.sub.6 together can represent methylenedioxy;and the salts thereof with physiologically acceptable acids are outstandingly effective in the treatment and prophylaxis of circulatory and cardiac diseases, e.g., hypertension and angina pectoris.

    摘要翻译: 式(I)的羧基 - (4) - 氧丙醇胺化合物,其中R 1是氢,低级烷酰基或芳酰基; R2是氢,低级烷基或芳基烷基; R3是氢或低级烷基; R4是氢或低级烷基,或者当X是氧时,R4与R5一起可以代表-CH2-O-; X是价键,-CH 2 - ,氧或硫; Ar是单环或双环芳基或吡啶基; R5和R6分别选自氢,卤素,羟基,低级烷基,氨基羰基,低级烷氧基,芳烷氧基,低级烷硫基,低级烷基亚磺酰基或低级烷基磺酰基; R5和R6一起可以代表亚甲二氧基; 并且其与生理上可接受的酸的盐在治疗和预防循环和心脏疾病例如高血压和心绞痛方面是显着的。