公开(公告)号：US06471069B2

公开(公告)日：2002-10-29

申请号：US09727162

申请日：2000-11-30

Applicant: Fu-Chung Lin ,  Paul C. DiCesare ,  Jeffrey Radziunas

Inventor： Fu-Chung Lin ,  Paul C. DiCesare ,  Jeffrey Radziunas

IPC: B01D2126

CPC classification number: B01L3/5021 ,  B01L3/50215 ,  B01L3/50825 ,  B01L2400/0605 ,  B01L2400/0638 ,  Y10T436/25375

Abstract: A device and method for separating heavier and lighter fractions of a fluid sample. The device includes a flexible collapsible inner container disposed within a substantially rigid outer container. A closure seals the open top end of the outer container. A filter assembly is sealingly mounted to the open top end of the inner container. The filter assembly includes a filter that permits lighter fractions to pass therethrough, while substantially blocking the heavier fractions. The filter assembly further includes a filter support having a slit valve registered with the filter. The slit valve opens in response to fluid pressure created by the lighter fractions for permitting the lighter fractions to flow therethrough. A fluid sample is delivered to the inner container and the device is subjected to centrifugation whereby the centrifugal load causes the filter assembly to move toward the bottom end of the outer container and thereby enable the lighter fraction of the fluid sample to flow through the slit valve and into the space between the inner and outer containers. The slit valve closes upon termination of the centrifugal load such that separation between the heavier and lighter fractions of the fluid sample are maintained.

Abstract translation: 用于分离流体样品的较重和较轻馏分的装置和方法。 该装置包括设置在基本刚性的外部容器内的柔性可折叠内部容器。 封闭件密封外部容器的敞开的顶端。 过滤器组件密封地安装到内部容器的敞开的顶端。 过滤器组件包括允许较轻馏分通过的过滤器，同时基本上阻挡较重的馏分。 过滤器组件还包括具有与过滤器配准的狭缝阀的过滤器支撑件。 狭缝阀响应于较轻馏分产生的流体压力打开，以允许较轻馏分流过其中。 流体样品被输送到内部容器并且装置进行离心，由此离心负载使得过滤器组件朝着外部容器的底端移动，从而使较轻部分的流体样品流过狭缝阀 并进入内外容器之间的空间。 在离心负载终止时，狭缝阀关闭，使得维持流体样品的较重和较轻馏分之间的分离。

公开(公告)号：US06516953B1

公开(公告)日：2003-02-11

申请号：US09452981

申请日：1999-12-02

Applicant: Paul C. DiCesare ,  Jeffrey Karg ,  Fu-Chung Lin ,  Jeffrey P. Radziunas

Inventor： Paul C. DiCesare ,  Jeffrey Karg ,  Fu-Chung Lin ,  Jeffrey P. Radziunas

IPC: B01D2126

CPC classification number: G01N33/491 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150236 ,  A61B5/150251 ,  A61B5/150351 ,  A61B5/150572 ,  A61B5/150755 ,  A61B5/154 ,  B01D21/0003 ,  B01D21/26 ,  B01D21/262 ,  B01D2221/10 ,  B01L3/50215 ,  B01L2300/042

Abstract: A device and method is provided for separating components of a fluid sample. The device includes a plurality of constituents comprising a container, a liner in the container, a closure for the container and a composite element. The composite element is a seal plug with a density between the densities of the components of the fluid sample is releasably engaged with the container closure and with the liner. A needle cannula is used to deposit a fluid sample in the liner and the entire device is placed in a centrifuge. The centrifugal load causes the seal plug to separate from the closure and causes the liner to expand outwardly against the container. The seal plug migrates into the fluid sample and stabilizes between the densities of the components of the fluid sample. The liner will resiliently return to its initial configuration upon termination of centrifugal load such that the liner sealingly engages the seal plug and separates the components of the fluid sample.

Abstract translation: 提供了用于分离流体样品的组分的装置和方法。 该装置包括多个构件，其包括容器，容器中的衬垫，用于容器的封闭件和复合元件。 复合元件是密封塞，其密度在流体样品的部件的密度之间与容器封闭件和衬套可释放地接合。 使用针插管将流体样品沉积在衬垫中，并将整个装置放置在离心机中。 离心载荷使得密封塞与封闭件分离并使衬套朝向容器向外扩张。 密封塞移动到流体样品中并且在流体样品的组分的密度之间稳定。 当离心负载终止时，衬套将弹性地返回到其初始构型，使得衬套密封地接合密封塞并分离流体样品的部件。

公开(公告)号：US06803022B2

公开(公告)日：2004-10-12

申请号：US09727282

申请日：2000-11-30

Applicant: Paul C. DiCesare ,  Jeffrey R. Radziunas ,  Robert Losada ,  Fu-Chung Lin

Inventor： Paul C. DiCesare ,  Jeffrey R. Radziunas ,  Robert Losada ,  Fu-Chung Lin

IPC: B01L1100

CPC classification number: B01L3/50215

Abstract: A device and method for separating heavier and lighter fractions of a fluid sample. The device includes a plurality of constituents comprising a container and a composite element in the container. The composite element is a separator comprising a deformable bellows, a ballast mounted to the lower end of the bellows, and a float is engageable with an upper end of the bellows. A fluid sample is delivered to the container and the device is subjected to centrifugation whereby the centrifugal load causes the ballast to move toward the bottom of the tube and causes an elongation and narrowing of the bellows. The separator then moves down the tube and stabilizes in a position between the separated phases of the fluid sample. Termination of the centrifugal load enables the bellows to return to its original condition in sealing engagement with the walls of the tube. The dense formed phase of the fluid sample will lie between the separator and the bottom of the tube, while less dense liquid phase of the fluid sample will be the separator.

Abstract translation: 用于分离流体样品的较重和较轻馏分的装置和方法。 该装置包括多个构件，其包括容器中的容器和复合元件。 复合元件是分离器，其包括可变形的波纹管，安装在波纹管的下端的压载物，浮子可与波纹管的上端接合。 将流体样品输送到容器，并且该装置进行离心，由此离心负载使压载物朝向管的底部移动并引起波纹管的伸长和变窄。 然后，分离器向下移动管并稳定在流体样品的分离相之间的位置。 离心负载的终止使得波纹管能够恢复到与管的壁密封接合的其初始状态。 流体样品的致密成形阶段将位于分离器和管的底部之间，而流体样品的较不致密的液相将是分离器。

公开(公告)号：US07112211B2

公开(公告)日：2006-09-26

申请号：US10339434

申请日：2003-01-09

Applicant: Hanson S. Gifford, III ,  Lee R. Bolduc ,  Jeffrey A. Stein ,  Paul C. DiCesare ,  Peter F. Costa ,  William A. Holmes

Inventor： Hanson S. Gifford, III ,  Lee R. Bolduc ,  Jeffrey A. Stein ,  Paul C. DiCesare ,  Peter F. Costa ,  William A. Holmes

IPC: A61B17/11

CPC classification number: A61B17/12109 ,  A61B17/064 ,  A61B17/0643 ,  A61B17/11 ,  A61B17/115 ,  A61B17/12036 ,  A61B17/12045 ,  A61B17/12136 ,  A61B2017/00243 ,  A61B2017/0641 ,  A61B2017/1135 ,  A61B2017/12127 ,  A61F2002/30092 ,  A61F2210/0014

Abstract: A system for performing an end-to-side vascular anastomosis. including an anastomosis device, an application instrument and methods for performing a vascular anastomosis. The system is applicable for performing an anastomosis between a vascular graft and the ascending aorta in coronary artery bypass surgery, particularly in port-access CABG surgery. A first aspect of the invention includes a vascular anastomosis staple. A first configuration has two parts: an anchor member, forming the attachment with the target vessel wall and a coupling member, forming the attachment with the bypass graft vessel. The anastomosis is completed by inserting the coupling member, with the graft vessel attached, into the anchor member. A second configuration combines the functions of the anchor member and the coupling member into a one-piece anastomosis staple. A second aspect of the invention includes an anastomotic fitting, having an inner flange over which the graft vessel is everted and an outer flange which contacts the exterior surface of the target vessel. A tailored amount of compression applied by the inner and outer flanges grips the target vessel wall and creates a leak-proof seal between the graft vessel and the target vessel. A third aspect of the invention has a flange to which the graft vessel attaches, by everting the graft vessel over the flange, and a plurality of staple-like members which attach the flange and the everted end of the graft vessel to the wall of the target vessel to form the anastomosis.

Abstract translation: 用于进行端对侧血管吻合的系统。 包括吻合装置，应用仪器和用于进行血管吻合的方法。 该系统适用于在冠状动脉旁路手术中进行血管移植物和升主动脉之间的吻合，特别是在进入CABG手术中。 本发明的第一方面包括血管吻合缝合物。 第一构造具有两部分：锚定构件，与目标血管壁形成附件和联接构件，与旁路移植血管形成附件。 通过将连接构件插入到锚定构件中来完成吻合。 第二种结构将锚定构件和联接构件的功能结合成一体式吻合钉。 本发明的第二方面包括一种吻合装置，其具有内部凸缘，移植物容器在其上延伸，外部凸缘接触目标血管的外表面。 由内外法兰施加的定制的压缩量夹住目标血管壁，并在移植血管和靶血管之间产生防漏密封。 本发明的第三方面具有凸缘，移植管通过使移植物容器穿过凸缘而附接到该凸缘上，以及多个钉状构件，其将该移植物容器的凸缘和脱出端附接到 靶血管形成吻合。

公开(公告)号：US06984238B2

公开(公告)日：2006-01-10

申请号：US10830952

申请日：2004-04-23

Applicant: Hanson S. Gifford, III ,  Lee R. Bolduc ,  Jeffrey A. Stein ,  Paul C. DiCesare ,  Peter F. Costa ,  William A. Holmes

Inventor： Hanson S. Gifford, III ,  Lee R. Bolduc ,  Jeffrey A. Stein ,  Paul C. DiCesare ,  Peter F. Costa ,  William A. Holmes

IPC: A61B17/11

CPC classification number: A61B17/12109 ,  A61B17/064 ,  A61B17/0643 ,  A61B17/11 ,  A61B17/115 ,  A61B17/12036 ,  A61B17/12045 ,  A61B17/12136 ,  A61B2017/00243 ,  A61B2017/0641 ,  A61B2017/1135 ,  A61B2017/12127 ,  A61F2002/30092 ,  A61F2210/0014

Abstract: A system for performing an end-to-side vascular anastomosis. including an anastomosis device, an application instrument and methods for performing a vascular anastomosis. The system is applicable for performing an anastomosis between a vascular graft and the ascending aorta in coronary artery bypass surgery, particularly in port-access CABG surgery. A first aspect of the invention includes a vascular anastomosis staple. A first configuration has two parts: an anchor member, forming the attachment with the target vessel wall and a coupling member, forming the attachment with the bypass graft vessel. The anastomosis is completed by inserting the coupling member, with the graft vessel attached, into the anchor member. A second configuration combines the functions of the anchor member and the coupling member into a one-piece anastomosis staple. A second aspect of the invention includes an anastomotic fitting, having an inner flange over which the graft vessel is everted and an outer flange which contacts the exterior surface of the target vessel. A tailored amount of compression applied by the inner and outer flanges grips the target vessel wall and creates a leak-proof seal between the graft vessel and the target vessel. A third aspect of the invention has a flange to which the graft vessel attaches, by everting the graft vessel over the flange, and a plurality of staple-like members which attach the flange and the everted end of the graft vessel to the wall of the target vessel to form the anastomosis

公开(公告)号：US06371965B2

公开(公告)日：2002-04-16

申请号：US09756447

申请日：2001-01-08

Applicant: Hanson S. Gifford, III ,  Lee R. Bolduc ,  Jeffrey A. Stein ,  Paul C. DiCesare ,  Peter F. Costa ,  William A. Holmes

Inventor： Hanson S. Gifford, III ,  Lee R. Bolduc ,  Jeffrey A. Stein ,  Paul C. DiCesare ,  Peter F. Costa ,  William A. Holmes

IPC: A61B1711

CPC classification number: A61B17/12109 ,  A61B17/064 ,  A61B17/0643 ,  A61B17/11 ,  A61B17/115 ,  A61B17/12036 ,  A61B17/12045 ,  A61B17/12136 ,  A61B2017/00243 ,  A61B2017/0641 ,  A61B2017/1135 ,  A61B2017/12127 ,  A61F2002/30092 ,  A61F2210/0014

Abstract: A system for performing an end-to-side vascular anastomosis, including an anastomosis device, an application instrument and methods for performing a vascular anastomosis. The system is applicable for performing an anastomosis between a vascular graft and the ascending aorta in coronary artery bypass surgery, particularly in port-access CABG surgery. A first aspect of the invention includes a vascular anastomosis staple. A first configuration has two parts: an anchor member, forming the attachment with the target vessel wall and a coupling member, forming the attachment with the bypass graft vessel. The anastomosis is completed by inserting the coupling member, with the graft vessel attached, into the anchor member. A second configuration combines the functions of the anchor member and the coupling member into a one-piece anastomosis staple. A second aspect of the invention includes an anastomotic fitting, having an inner flange over which the graft vessel is everted and an outer flange which contacts the exterior surface of the target vessel. A tailored amount of compression applied by the inner and outer flanges grips the target vessel wall and creates a leak-proof seal between the graft vessel and the target vessel. A third aspect of the invention has a flange to which the graft vessel attaches, by everting the graft vessel over the flange, and a plurality of staple-like members which attach the flange and the everted end of the graft vessel to the wall of the target vessel to form the anastomosis.

公开(公告)号：US06267772B1

公开(公告)日：2001-07-31

申请号：US09291651

申请日：1999-04-06

Applicant: Paul J. Mulhauser ,  Paul C. DiCesare

Inventor： Paul J. Mulhauser ,  Paul C. DiCesare

IPC: A61B1700

CPC classification number: A61F2/0063 ,  A61B17/00234 ,  A61F2/02 ,  A61F2002/0072 ,  A61F2002/009 ,  B29C2045/14885

Abstract: An implantable prosthesis for occluding the opening of a muscle or tissue defect. The implant is laparoscopically deliverable with a system for loading and delivering the prosthesis through a trocar cannula. The prosthesis includes an implantable material with a body portion sufficient to extend across and occlude a defect opening. Antimigration barbs extend from the implantable material to prevent migration of the prosthesis after implantation. A semi-rigid ring may be attached to the material for supporting the body portion. The barbs may be located on the ring. The implantable prosthesis may be provided with a sufficient hoop strength to prevent the body portion from collapsing into the defect opening.

Abstract translation: 用于闭塞肌肉或组织缺损开放的可植入假体。 该植入物具有腹腔镜可递送的系统，用于通过套管针套管装载和输送假体。 假体包括可植入材料，其具有足以延伸并阻塞缺损开口的主体部分。 抗迁移倒钩从可植入材料延伸，以防止假体在植入后迁移。 半刚性环可以附着到用于支撑身体部分的材料上。 倒钩可能位于环上。 可植入的假体可以具有足够的箍强度以防止主体部分塌陷到缺损开口中。

公开(公告)号：US06171321B2

公开(公告)日：2001-01-09

申请号：US09315365

申请日：1999-05-18

Applicant: Hanson S. Gifford, III ,  Lee R. Bolduc ,  Jeffrey A. Stein ,  Paul C. DiCesare ,  Peter F. Costa ,  William A. Holmes

Inventor： Hanson S. Gifford, III ,  Lee R. Bolduc ,  Jeffrey A. Stein ,  Paul C. DiCesare ,  Peter F. Costa ,  William A. Holmes

IPC: A61B1711

CPC classification number: A61B17/12109 ,  A61B17/064 ,  A61B17/0643 ,  A61B17/11 ,  A61B17/115 ,  A61B17/12036 ,  A61B17/12045 ,  A61B17/12136 ,  A61B2017/00243 ,  A61B2017/0641 ,  A61B2017/1135 ,  A61B2017/12127 ,  A61F2002/30092 ,  A61F2210/0014

Abstract: A system for performing an end-to-side vascular anastomosis, including an anastomosis device, an application instrument and methods for performing a vascular anastomosis. The system is applicable for performing an anastomosis between a vascular graft and the ascending aorta in coronary artery bypass surgery, particularly in port-access CABG surgery. A first aspect of the invention includes a vascular anastomosis staple. A first configuration has two parts: an anchor member, forming the attachment with the target vessel wall and a coupling member. forming the attachment with the bypass graft vessel. The anastomosis is completed by inserting the coupling member, with the graft vessel attached, into the anchor member. A second configuration combines the functions of the anchor member and the coupling member into a one-piece anastomosis staple. A second aspect of the invention includes an anastomotic fitting, having an inner flange over which the graft vessel is everted and an outer flange which contacts the exterior surface of the target vessel. A tailored amount of compression applied by the inner and outer flanges grips the target vessel wall and creates a leak-proof seal between the graft vessel and the target vessel. A third aspect of the invention has a flange to which the graft vessel attaches, by everting the graft vessel over the flange, and a plurality of staple-like members which attach the flange and the everted end of the graft vessel to the wall of the target vessel to form the anastomosis.

Abstract translation: 一种用于执行端对侧血管吻合的系统，包括吻合装置，应用仪器和用于进行血管吻合的方法。 该系统适用于在冠状动脉旁路手术中进行血管移植物和升主动脉之间的吻合，特别是在进入CABG手术中。 本发明的第一方面包括血管吻合缝合物。 第一构造具有两部分：锚定构件，与靶血管壁形成附件和联接构件。 用旁路移植血管形成附件。 通过将连接构件插入到锚定构件中来完成吻合。 第二种结构将锚定构件和联接构件的功能结合成一体式吻合钉。 本发明的第二方面包括一种吻合装置，其具有内部凸缘，移植物容器在其上延伸，外部凸缘接触目标血管的外表面。 由内外法兰施加的定制的压缩量夹住目标血管壁，并在移植血管和靶血管之间产生防漏密封。 本发明的第三方面具有凸缘，移植管通过使移植物容器穿过凸缘而附接到该凸缘上，以及多个钉状构件，其将该移植物容器的凸缘和脱出端附接到 靶血管形成吻合。

公开(公告)号：US5695525A

公开(公告)日：1997-12-09

申请号：US485714

申请日：1995-06-07

Applicant: Paul J. Mulhauser ,  Paul C. DiCesare

Inventor： Paul J. Mulhauser ,  Paul C. DiCesare

IPC: A61B17/00 ,  A61F2/00 ,  A61F2/08

CPC classification number: A61F2/0063 ,  A61F2/02 ,  A61B17/00234 ,  A61F2002/0072 ,  A61F2002/009 ,  B29C2045/14885

Abstract: An implantable prosthesis and device and method for loading and delivering the implantable prosthesis to a trocar cannula. The implantable prosthesis includes a body portion sufficient to extend across and occlude a defect opening and a semi-rigid ring for supporting the body portion. The implantable prosthesis may be provided with a sufficient hoop strength to prevent the body portion from collapsing into the defect opening. A loading and delivery tool includes a main body with a lumen sized to collapse the implantable prosthesis. An elongated shaft is rotatable to wind the implant into a slender configuration and axially moveable to advance the rolled-up implant into the trocar cannula. A cartridge extends from the main body and holds the implant in a normal expanded configuration.

Abstract translation: 一种用于将可植入假体装载并递送到套管针套管的可植入假体和装置和方法。 可植入假体包括足以延伸穿过缺损开口的主体部分和用于支撑身体部分的半刚性环。 可植入的假体可以具有足够的箍强度以防止主体部分塌陷到缺损开口中。 装载和递送工具包括主体，其具有尺寸适于折叠可植入假体的内腔。 细长轴可旋转以将植入物卷绕成细长的构造并且可轴向移动以将卷起的植入物推进到套针套管中。 药筒从主体延伸并且以正常的扩张构型保持植入物。

公开(公告)号：US4562839A

公开(公告)日：1986-01-07

申请号：US456163

申请日：1983-01-06

Applicant: Joseph W. Blake, III ,  Paul C. DiCesare

Inventor： Joseph W. Blake, III ,  Paul C. DiCesare

IPC: A61B17/12 ,  A61B17/128 ,  A61B17/28

CPC classification number: A61B17/128 ,  A61B2017/2929

Abstract: An instrument for applying clips to a surgical site has an applicator with two jaws which are movable between open and closed positions. A mechanism is provided for feeding the respectively leading clip of a string of such clips between the jaws, whereupon the jaws are closed and the leading clip is cinched as it is being applied to the surgical site. To vary the presentation of the clip, i.e., its orientation relative to the surgical site, the mechanism is mounted so that it can turn about a longitudinal axis of the instrument. In one embodiment, a slide button is provided which can be slid forward and backward with one finger of a user, such translatory movement of the button being converted into a turning movement of the mechanism and consequently also of the clip which is being held between the anvils preparatory to its application to the surgical site. In another embodiment, turning movement is effected by rotating a knob secured to the mechanism.

Abstract translation: 用于将夹子应用于外科手术部位的器具具有两个可在打开位置和闭合位置之间移动的钳口。 提供了一种用于将这样的夹子的线的分别引导的夹子馈送在钳口之间的机构，于是钳口被关闭，并且引导夹子在被施加到外科手术部位时被束紧。 为了改变夹子的呈现，即其相对于手术部位的取向，该机构被安装成使得其可以围绕器械的纵向轴线转动。 在一个实施例中，提供了可以用用户的一个手指向前和向后滑动的滑动按钮，按钮的这种平移运动被转换成该机构的转动运动，因此也被夹持在 砧座准备应用于手术部位。 在另一个实施例中，通过旋转固定到机构的旋钮实现转动运动。