-
公开(公告)号：US06516953B1
公开(公告)日：2003-02-11
申请号：US09452981
申请日：1999-12-02
IPC分类号： B01D2126
CPC分类号： G01N33/491 , A61B5/15003 , A61B5/150221 , A61B5/150236 , A61B5/150251 , A61B5/150351 , A61B5/150572 , A61B5/150755 , A61B5/154 , B01D21/0003 , B01D21/26 , B01D21/262 , B01D2221/10 , B01L3/50215 , B01L2300/042
摘要： A device and method is provided for separating components of a fluid sample. The device includes a plurality of constituents comprising a container, a liner in the container, a closure for the container and a composite element. The composite element is a seal plug with a density between the densities of the components of the fluid sample is releasably engaged with the container closure and with the liner. A needle cannula is used to deposit a fluid sample in the liner and the entire device is placed in a centrifuge. The centrifugal load causes the seal plug to separate from the closure and causes the liner to expand outwardly against the container. The seal plug migrates into the fluid sample and stabilizes between the densities of the components of the fluid sample. The liner will resiliently return to its initial configuration upon termination of centrifugal load such that the liner sealingly engages the seal plug and separates the components of the fluid sample.
摘要翻译： 提供了用于分离流体样品的组分的装置和方法。 该装置包括多个构件，其包括容器，容器中的衬垫，用于容器的封闭件和复合元件。 复合元件是密封塞，其密度在流体样品的部件的密度之间与容器封闭件和衬套可释放地接合。 使用针插管将流体样品沉积在衬垫中，并将整个装置放置在离心机中。 离心载荷使得密封塞与封闭件分离并使衬套朝向容器向外扩张。 密封塞移动到流体样品中并且在流体样品的组分的密度之间稳定。 当离心负载终止时，衬套将弹性地返回到其初始构型，使得衬套密封地接合密封塞并分离流体样品的部件。
-
公开(公告)号：US06479298B1
公开(公告)日：2002-11-12
申请号：US09454988
申请日：1999-12-03
IPC分类号： G01N118
CPC分类号： B01L3/50215 , G01N33/491 , Y10T436/25 , Y10T436/25375
摘要： A device and method for separating heavier and lighter fractions of a fluid sample. The device includes a plurality of constituents comprising a container and a composite element in the container. The composite element is a separator comprising at least two components and more particularly, a bellows with a seal body, a low-density float and a high-density ballast. A fluid sample is delivered to the container and the device is subjected to centrifugation whereby the centrifugal load causes the seal body of the separator to deform so that the separator migrates through the fluid sample and then stabilizes between the heavier and lighter fractions of the fluid sample. The seal body of the separator will resiliently return to its initial configuration upon termination of the centrifugal load such that the seal body sealingly engages the container and the composite element separates the heavier and lighter fractions of the fluid sample.
摘要翻译： 用于分离流体样品的较重和较轻馏分的装置和方法。 该装置包括多个构件，其包括容器中的容器和复合元件。 复合元件是包括至少两个部件的分离器，更具体地，具有密封体，低密度浮子和高密度压载物的波纹管。 将流体样品输送到容器并且使装置进行离心，由此离心负荷使得分离器的密封体变形，使得分离器通过流体样品移动，然后在流体样品的较重和较轻部分之间稳定 。 当离心负载终止时，分离器的密封体将弹性地返回到其初始构型，使得密封体密封地接合容器，并且复合元件分离流体样品的较重和较轻的部分。
-
公开(公告)号：US06471069B2
公开(公告)日：2002-10-29
申请号：US09727162
申请日：2000-11-30
IPC分类号： B01D2126
CPC分类号： B01L3/5021 , B01L3/50215 , B01L3/50825 , B01L2400/0605 , B01L2400/0638 , Y10T436/25375
摘要： A device and method for separating heavier and lighter fractions of a fluid sample. The device includes a flexible collapsible inner container disposed within a substantially rigid outer container. A closure seals the open top end of the outer container. A filter assembly is sealingly mounted to the open top end of the inner container. The filter assembly includes a filter that permits lighter fractions to pass therethrough, while substantially blocking the heavier fractions. The filter assembly further includes a filter support having a slit valve registered with the filter. The slit valve opens in response to fluid pressure created by the lighter fractions for permitting the lighter fractions to flow therethrough. A fluid sample is delivered to the inner container and the device is subjected to centrifugation whereby the centrifugal load causes the filter assembly to move toward the bottom end of the outer container and thereby enable the lighter fraction of the fluid sample to flow through the slit valve and into the space between the inner and outer containers. The slit valve closes upon termination of the centrifugal load such that separation between the heavier and lighter fractions of the fluid sample are maintained.
摘要翻译： 用于分离流体样品的较重和较轻馏分的装置和方法。 该装置包括设置在基本刚性的外部容器内的柔性可折叠内部容器。 封闭件密封外部容器的敞开的顶端。 过滤器组件密封地安装到内部容器的敞开的顶端。 过滤器组件包括允许较轻馏分通过的过滤器，同时基本上阻挡较重的馏分。 过滤器组件还包括具有与过滤器配准的狭缝阀的过滤器支撑件。 狭缝阀响应于较轻馏分产生的流体压力打开，以允许较轻馏分流过其中。 流体样品被输送到内部容器并且装置进行离心，由此离心负载使得过滤器组件朝着外部容器的底端移动，从而使较轻部分的流体样品流过狭缝阀 并进入内外容器之间的空间。 在离心负载终止时，狭缝阀关闭，使得维持流体样品的较重和较轻馏分之间的分离。
-
公开(公告)号：US06803022B2
公开(公告)日：2004-10-12
申请号：US09727282
申请日：2000-11-30
IPC分类号： B01L1100
CPC分类号： B01L3/50215
摘要： A device and method for separating heavier and lighter fractions of a fluid sample. The device includes a plurality of constituents comprising a container and a composite element in the container. The composite element is a separator comprising a deformable bellows, a ballast mounted to the lower end of the bellows, and a float is engageable with an upper end of the bellows. A fluid sample is delivered to the container and the device is subjected to centrifugation whereby the centrifugal load causes the ballast to move toward the bottom of the tube and causes an elongation and narrowing of the bellows. The separator then moves down the tube and stabilizes in a position between the separated phases of the fluid sample. Termination of the centrifugal load enables the bellows to return to its original condition in sealing engagement with the walls of the tube. The dense formed phase of the fluid sample will lie between the separator and the bottom of the tube, while less dense liquid phase of the fluid sample will be the separator.
摘要翻译： 用于分离流体样品的较重和较轻馏分的装置和方法。 该装置包括多个构件，其包括容器中的容器和复合元件。 复合元件是分离器，其包括可变形的波纹管，安装在波纹管的下端的压载物，浮子可与波纹管的上端接合。 将流体样品输送到容器，并且该装置进行离心，由此离心负载使压载物朝向管的底部移动并引起波纹管的伸长和变窄。 然后，分离器向下移动管并稳定在流体样品的分离相之间的位置。 离心负载的终止使得波纹管能够恢复到与管的壁密封接合的其初始状态。 流体样品的致密成形阶段将位于分离器和管的底部之间，而流体样品的较不致密的液相将是分离器。
-
公开(公告)号：US06497325B1
公开(公告)日：2002-12-24
申请号：US09454267
申请日：1999-12-03
申请人： Paul DiCesare , Jeffrey Karg , Fu-Chung Lin
发明人： Paul DiCesare , Jeffrey Karg , Fu-Chung Lin
IPC分类号： B01D2126
CPC分类号： B01L3/50215
摘要： A device and method is provided for separating heavier and lighter fractions of a fluid sample. The device includes a plurality of constituents. The constituents include a container, a liner in the container and a composite element in the liner for separating the fractions of a fluid sample. The separator comprises a specific density at a target density range as defined by separable fluid components densities. A fluid sample is delivered to the liner and then the device is subjected to centrifugation whereby the centrifugal load causes the liner to deform and the composite element migrates into the fluid sample and stabilizes between the heavier and lighter fractions of the fluid sample. The liner will resiliently return to its initial configuration upon termination of the centrifugal load such that the liner sealingly engages the composite element and separates the heavier and lighter fractions of the fluid sample.
摘要翻译： 提供了用于分离流体样品的较重和较轻馏分的装置和方法。 该装置包括多个成分。 组分包括容器，容器中的衬垫和用于分离流体样品的级分的衬垫中的复合元件。 分离器包括由可分离的流体组分密度所限定的目标密度范围的特定密度。 将流体样品输送到衬套，然后使装置进行离心，由此离心负载导致衬套变形，并且复合元件迁移到流体样品中并且在流体样品的较重和较轻部分之间稳定。 衬垫将在离心负载终止时弹性地返回到其初始构型，使得衬套密封地接合复合元件并分离流体样品的较重和较轻的部分。
-
6.发明授权Receptacle with a fused coating on an interior surface and an injection molding process for forming the article 失效在内表面上具有熔融涂层的容器和用于形成制品的注射成型工艺
公开(公告)号：US6017483A
公开(公告)日：2000-01-25
申请号：US896339
申请日：1997-07-18
申请人： Fu-Chung Lin
发明人： Fu-Chung Lin
IPC分类号： A61B5/154 , B29C37/00 , B29C41/08 , B29C41/12 , B29C41/14 , B29C45/14 , B29C45/16 , B29C45/26 , B29C33/52
CPC分类号： B29C37/0032 , B29C45/14778 , B29C2045/14319 , B29C41/08 , B29C41/12 , B29C41/14 , B29L2031/712
摘要： An injection molding method for forming an article having a receptacle with a coating on an interior surface includes providing an injection molding tool with at least one cavity in one part and at least one core pin projecting from a second part having an outside surface. The core pin is sized to fit within the cavity with a clearance thereby defining a cavity space. The injection molding tool has an open position wherein the core pin is withdrawn from the cavity and a closed position wherein the core pin is disposed within the cavity for defining the cavity space. The method further sequentially then includes moving the injection molding tool to the open position and applying a coating of a coating material to the outside surface of the core pin. The method further includes moving the injection molding tool to the closed position. The method then includes filling the cavity space with a thermoplastic substrate material, the substrate material being maintained at a temperature wherein the substrate material exhibits plastic flow, thereby fusing the coating material to the substrate material. The method of the invention then includes cooling the substrate material to a temperature wherein the substrate material becomes substantially solid, thereby forming an article from the substrate material having a receptacle with an interior surface with the coating material fused thereto. The method then includes returning the molding tool to the open position; and removing the article.
摘要翻译： 一种用于形成具有在内表面上具有涂层的容器的制品的注射成型方法，包括提供具有一个部分中的至少一个空腔和至少一个从具有外表面的第二部分突出的芯销的注射模制工具。 芯销的尺寸被设计成以间隙装配在腔内，从而限定空腔。 注射成型工具具有打开位置，其中芯销从空腔中取出并且闭合位置，其中芯销设置在空腔内以限定空腔。 该方法进一步依次包括将注射模制工具移动到打开位置并且将涂层材料的涂层施加到芯销的外表面。 该方法还包括将注射模具移动到关闭位置。 该方法然后包括用热塑性基底材料填充空腔，衬底材料保持在其中衬底材料表现出塑性流动的温度，从而将涂层材料熔合到衬底材料上。 然后，本发明的方法包括将衬底材料冷却到其中衬底材料变得基本上是固体的温度，从而从具有内表面的容器的衬底材料形成制品，其中涂覆材料与其融合。 该方法然后包括将模制工具返回到打开位置; 并移除文章。
-
公开(公告)号：US07947236B2
公开(公告)日：2011-05-24
申请号：US10785893
申请日：2004-02-24
CPC分类号： B01L3/50215 , B04B7/08 , G01N33/491 , Y10T29/49826
摘要： A device for separating heavier and lighter fractions of a fluid sample is provided, the device including a container and a unitary separator located therein, the separator having an overall density between the heavier and light fractions. The separator is capable of moving between the fractions upon centrifugation, and sealing the fractions from one another when centrifugation ends.
摘要翻译： 提供了一种用于分离流体样品的较重和较轻馏分的装置，该装置包括容器和位于其中的整体分离器，该分离器具有较重和较轻部分之间的总体密度。 分离器能够在离心后在各部分之间移动，并且当离心结束时将分离物彼此密封。
-
公开(公告)号：US08524171B2
公开(公告)日：2013-09-03
申请号：US13085831
申请日：2011-04-13
IPC分类号： B01D21/00
CPC分类号： B01L3/50215 , B04B7/08 , G01N33/491 , Y10T29/49826
摘要： A device for separating heavier and lighter fractions of a fluid sample is provided, the device including a container and a unitary separator located therein, the separator having an overall density between the heavier and light fractions. The separator is capable of moving between the fractions upon centrifugation, and sealing the fractions from one another when centrifugation ends.
摘要翻译： 提供了一种用于分离流体样品的较重和较轻馏分的装置，该装置包括容器和位于其中的整体分离器，该分离器具有较重和较轻部分之间的总体密度。 分离器能够在离心后在各部分之间移动，并且当离心结束时将分离物彼此密封。
-
公开(公告)号：US20080241001A1
公开(公告)日：2008-10-02
申请号：US11937954
申请日：2007-11-09
申请人： Bruce Haywood , Ajit Dastane , Fu-Chung Lin
发明人： Bruce Haywood , Ajit Dastane , Fu-Chung Lin
IPC分类号： B01L3/02
CPC分类号： A61B5/417 , A61B5/15003 , A61B5/150221 , A61B5/150236 , A61B5/150244 , A61B5/150274 , A61B5/150351 , A61B5/150366 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150893 , A61B5/154 , A61J1/05 , A61J1/12 , A61J7/00 , A61J7/0053 , B01L3/02 , B01L3/50 , B01L3/5082 , B01L2200/16 , B01L2300/0609 , C12M23/12 , C12M33/04 , G01N35/1095 , Y10T436/2525 , Y10T436/25375
摘要： A collection container and a method for collecting a biological sample, particularly whole blood, includes at least one stabilizing agent in an amount effective to stabilize and inhibit protein degradation and/or fragmentation. The stabilizing agent is able to stabilize proteases in the biological sample, particularly at the point of collection, by inhibiting protein degradation and/or fragmentation in the sample when the sample is stored. The stabilizing agent comprises or consists of one or more protease inhibitors.
摘要翻译： 收集容器和收集生物样品，特别是全血的方法包括至少一种有效稳定和抑制蛋白质降解和/或破碎的稳定剂。 当储存样品时，稳定剂能够通过抑制样品中的蛋白质降解和/或碎裂来稳定生物样品中的蛋白酶，特别是在收集点。 稳定剂包含或由一种或多种蛋白酶抑制剂组成。
-
公开(公告)号：US20110187021A1
公开(公告)日：2011-08-04
申请号：US13085831
申请日：2011-04-13
IPC分类号： B29C45/14
CPC分类号： B01L3/50215 , B04B7/08 , G01N33/491 , Y10T29/49826
摘要： A device for separating heavier and lighter fractions of a fluid sample is provided, the device including a container and a unitary separator located therein, the separator having an overall density between the heavier and light fractions. The separator is capable of moving between the fractions upon centrifugation, and sealing the fractions from one another when centrifugation ends.
摘要翻译： 提供了一种用于分离流体样品的较重和较轻馏分的装置，该装置包括容器和位于其中的整体分离器，该分离器具有较重和较轻部分之间的总体密度。 分离器能够在离心后在各部分之间移动，并且当离心结束时将分离物彼此密封。
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.045 秒)
