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    Membrane-based Double-layer Tube for Sample Collections
    1.
    发明申请
    Membrane-based Double-layer Tube for Sample Collections 审中-公开
    用于样品集合的膜基双层管

    公开(公告)号：US20080017577A1

    公开(公告)日：2008-01-24

    申请号：US11459076

    申请日：2006-07-21

    Applicant: Jizu Yi ,  Fu Chung Lin ,  Dimitrios Manoussakis ,  Craig Gelfand

    Inventor： Jizu Yi ,  Fu Chung Lin ,  Dimitrios Manoussakis ,  Craig Gelfand

    IPC: B01D61/18

    CPC classification number: B01L3/50825 ,  B01L3/502 ,  B01L3/5021 ,  B01L2300/047 ,  B01L2300/0672 ,  B01L2300/0681 ,  B01L2400/049

    Abstract: The fluid sample collection device is adapted to collect and separate a fluid sample into constituent parts such as separating plasma or serum from a blood sample. The device includes an evacuated outer container and an inner container. The outer container has a first open end and a second closed end. A pierceable closure closes the first open end thereby defining a first interior chamber. The inner container is contained within the outer container and separates the first interior chamber into an upper chamber portion and lower chamber portion in fluid communication. The inner container defines a second interior chamber separated from the lower chamber portion through a porous membrane. A port is provided for placing the second interior chamber in fluid communication with the first interior chamber. Another aspect of the device relates to a method of using the device to separate plasma or serum from a blood sample.

    Abstract translation: 流体样品收集装置适于将流体样品收集并分离成组成部分，例如从血液样品分离血浆或血清。 该装置包括抽真空的外部容器和内部容器。 外容器具有第一开口端和第二闭合端。 可刺破的封闭件封闭第一开口端，由此限定第一内部腔室。 内部容器被容纳在外部容器内并且将第一内部腔室分离成上部腔室部分和下部腔室部分，以使其流体连通。 内部容器限定通过多孔膜与下部室分隔开的第二内部室。 提供端口用于将第二内部腔室与第一内部腔室流体连通。 该装置的另一方面涉及使用该装置将血浆或血清与血液样品分离的方法。

    Device for separating components of a fluid sample
    2.
    发明授权
    Device for separating components of a fluid sample 有权
    用于分离流体样品的组分的装置

    公开(公告)号：US06516953B1

    公开(公告)日：2003-02-11

    申请号：US09452981

    申请日：1999-12-02

    Applicant: Paul C. DiCesare ,  Jeffrey Karg ,  Fu-Chung Lin ,  Jeffrey P. Radziunas

    Inventor： Paul C. DiCesare ,  Jeffrey Karg ,  Fu-Chung Lin ,  Jeffrey P. Radziunas

    IPC: B01D2126

    CPC classification number: G01N33/491 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150236 ,  A61B5/150251 ,  A61B5/150351 ,  A61B5/150572 ,  A61B5/150755 ,  A61B5/154 ,  B01D21/0003 ,  B01D21/26 ,  B01D21/262 ,  B01D2221/10 ,  B01L3/50215 ,  B01L2300/042

    Abstract: A device and method is provided for separating components of a fluid sample. The device includes a plurality of constituents comprising a container, a liner in the container, a closure for the container and a composite element. The composite element is a seal plug with a density between the densities of the components of the fluid sample is releasably engaged with the container closure and with the liner. A needle cannula is used to deposit a fluid sample in the liner and the entire device is placed in a centrifuge. The centrifugal load causes the seal plug to separate from the closure and causes the liner to expand outwardly against the container. The seal plug migrates into the fluid sample and stabilizes between the densities of the components of the fluid sample. The liner will resiliently return to its initial configuration upon termination of centrifugal load such that the liner sealingly engages the seal plug and separates the components of the fluid sample.

    Abstract translation: 提供了用于分离流体样品的组分的装置和方法。 该装置包括多个构件，其包括容器，容器中的衬垫，用于容器的封闭件和复合元件。 复合元件是密封塞，其密度在流体样品的部件的密度之间与容器封闭件和衬套可释放地接合。 使用针插管将流体样品沉积在衬垫中，并将整个装置放置在离心机中。 离心载荷使得密封塞与封闭件分离并使衬套朝向容器向外扩张。 密封塞移动到流体样品中并且在流体样品的组分的密度之间稳定。 当离心负载终止时，衬套将弹性地返回到其初始构型，使得衬套密封地接合密封塞并分离流体样品的部件。

    Receptacle with a fused coating on an interior surface and an injection molding process for forming the article
    3.
    发明授权
    Receptacle with a fused coating on an interior surface and an injection molding process for forming the article 失效
    在内表面上具有熔融涂层的容器和用于形成制品的注射成型工艺

    公开(公告)号：US6017483A

    公开(公告)日：2000-01-25

    申请号：US896339

    申请日：1997-07-18

    Applicant: Fu-Chung Lin

    Inventor： Fu-Chung Lin

    IPC: A61B5/154 ,  B29C37/00 ,  B29C41/08 ,  B29C41/12 ,  B29C41/14 ,  B29C45/14 ,  B29C45/16 ,  B29C45/26 ,  B29C33/52

    CPC classification number: B29C37/0032 ,  B29C45/14778 ,  B29C2045/14319 ,  B29C41/08 ,  B29C41/12 ,  B29C41/14 ,  B29L2031/712

    Abstract: An injection molding method for forming an article having a receptacle with a coating on an interior surface includes providing an injection molding tool with at least one cavity in one part and at least one core pin projecting from a second part having an outside surface. The core pin is sized to fit within the cavity with a clearance thereby defining a cavity space. The injection molding tool has an open position wherein the core pin is withdrawn from the cavity and a closed position wherein the core pin is disposed within the cavity for defining the cavity space. The method further sequentially then includes moving the injection molding tool to the open position and applying a coating of a coating material to the outside surface of the core pin. The method further includes moving the injection molding tool to the closed position. The method then includes filling the cavity space with a thermoplastic substrate material, the substrate material being maintained at a temperature wherein the substrate material exhibits plastic flow, thereby fusing the coating material to the substrate material. The method of the invention then includes cooling the substrate material to a temperature wherein the substrate material becomes substantially solid, thereby forming an article from the substrate material having a receptacle with an interior surface with the coating material fused thereto. The method then includes returning the molding tool to the open position; and removing the article.

    Abstract translation: 一种用于形成具有在内表面上具有涂层的容器的制品的注射成型方法，包括提供具有一个部分中的至少一个空腔和至少一个从具有外表面的第二部分突出的芯销的注射模制工具。 芯销的尺寸被设计成以间隙装配在腔内，从而限定空腔。 注射成型工具具有打开位置，其中芯销从空腔中取出并且闭合位置，其中芯销设置在空腔内以限定空腔。 该方法进一步依次包括将注射模制工具移动到打开位置并且将涂层材料的涂层施加到芯销的外表面。 该方法还包括将注射模具移动到关闭位置。 该方法然后包括用热塑性基底材料填充空腔，衬底材料保持在其中衬底材料表现出塑性流动的温度，从而将涂层材料熔合到衬底材料上。 然后，本发明的方法包括将衬底材料冷却到其中衬底材料变得基本上是固体的温度，从而从具有内表面的容器的衬底材料形成制品，其中涂覆材料与其融合。 该方法然后包括将模制工具返回到打开位置; 并移除文章。

    Device For Separating Components of a Fluid Sample
    4.
    发明申请
    Device For Separating Components of a Fluid Sample 有权
    用于分离流体样品的组分的装置

    公开(公告)号：US20110187021A1

    公开(公告)日：2011-08-04

    申请号：US13085831

    申请日：2011-04-13

    Applicant: Robert J. Losada ,  Fu-Chung Lin ,  Gregory L. Lusardi

    Inventor： Robert J. Losada ,  Fu-Chung Lin ,  Gregory L. Lusardi

    IPC: B29C45/14

    CPC classification number: B01L3/50215 ,  B04B7/08 ,  G01N33/491 ,  Y10T29/49826

    Abstract: A device for separating heavier and lighter fractions of a fluid sample is provided, the device including a container and a unitary separator located therein, the separator having an overall density between the heavier and light fractions. The separator is capable of moving between the fractions upon centrifugation, and sealing the fractions from one another when centrifugation ends.

    Abstract translation: 提供了一种用于分离流体样品的较重和较轻馏分的装置，该装置包括容器和位于其中的整体分离器，该分离器具有较重和较轻部分之间的总体密度。 分离器能够在离心后在各部分之间移动，并且当离心结束时将分离物彼此密封。

    Device for separating components of a fluid sample
    9.
    发明授权
    Device for separating components of a fluid sample 有权
    用于分离流体样品的组分的装置

    公开(公告)号：US06497325B1

    公开(公告)日：2002-12-24

    申请号：US09454267

    申请日：1999-12-03

    Applicant: Paul DiCesare ,  Jeffrey Karg ,  Fu-Chung Lin

    Inventor： Paul DiCesare ,  Jeffrey Karg ,  Fu-Chung Lin

    IPC: B01D2126

    CPC classification number: B01L3/50215

    Abstract: A device and method is provided for separating heavier and lighter fractions of a fluid sample. The device includes a plurality of constituents. The constituents include a container, a liner in the container and a composite element in the liner for separating the fractions of a fluid sample. The separator comprises a specific density at a target density range as defined by separable fluid components densities. A fluid sample is delivered to the liner and then the device is subjected to centrifugation whereby the centrifugal load causes the liner to deform and the composite element migrates into the fluid sample and stabilizes between the heavier and lighter fractions of the fluid sample. The liner will resiliently return to its initial configuration upon termination of the centrifugal load such that the liner sealingly engages the composite element and separates the heavier and lighter fractions of the fluid sample.

    Abstract translation: 提供了用于分离流体样品的较重和较轻馏分的装置和方法。 该装置包括多个成分。 组分包括容器，容器中的衬垫和用于分离流体样品的级分的衬垫中的复合元件。 分离器包括由可分离的流体组分密度所限定的目标密度范围的特定密度。 将流体样品输送到衬套，然后使装置进行离心，由此离心负载导致衬套变形，并且复合元件迁移到流体样品中并且在流体样品的较重和较轻部分之间稳定。 衬垫将在离心负载终止时弹性地返回到其初始构型，使得衬套密封地接合复合元件并分离流体样品的较重和较轻的部分。

    Device and method for separating components of a fluid sample
    10.
    发明授权
    Device and method for separating components of a fluid sample 有权
    用于分离流体样品组分的装置和方法

    公开(公告)号：US06479298B1

    公开(公告)日：2002-11-12

    申请号：US09454988

    申请日：1999-12-03

    Applicant: Henry F. Miller ,  Fu-Chung Lin ,  Robert J. Losada ,  Jeffrey P. Radziunas ,  Jeffrey Karg

    Inventor： Henry F. Miller ,  Fu-Chung Lin ,  Robert J. Losada ,  Jeffrey P. Radziunas ,  Jeffrey Karg

    IPC: G01N118

    CPC classification number: B01L3/50215 ,  G01N33/491 ,  Y10T436/25 ,  Y10T436/25375

    Abstract: A device and method for separating heavier and lighter fractions of a fluid sample. The device includes a plurality of constituents comprising a container and a composite element in the container. The composite element is a separator comprising at least two components and more particularly, a bellows with a seal body, a low-density float and a high-density ballast. A fluid sample is delivered to the container and the device is subjected to centrifugation whereby the centrifugal load causes the seal body of the separator to deform so that the separator migrates through the fluid sample and then stabilizes between the heavier and lighter fractions of the fluid sample. The seal body of the separator will resiliently return to its initial configuration upon termination of the centrifugal load such that the seal body sealingly engages the container and the composite element separates the heavier and lighter fractions of the fluid sample.

    Abstract translation: 用于分离流体样品的较重和较轻馏分的装置和方法。 该装置包括多个构件，其包括容器中的容器和复合元件。 复合元件是包括至少两个部件的分离器，更具体地，具有密封体，低密度浮子和高密度压载物的波纹管。 将流体样品输送到容器并且使装置进行离心，由此离心负荷使得分离器的密封体变形，使得分离器通过流体样品移动，然后在流体样品的较重和较轻部分之间稳定 。 当离心负载终止时，分离器的密封体将弹性地返回到其初始构型，使得密封体密封地接合容器，并且复合元件分离流体样品的较重和较轻的部分。

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