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    Dihydropyridine derivatives
    6.
    发明授权
    Dihydropyridine derivatives 失效
    二氢吡啶衍生物

    公开(公告)号：US4910195A

    公开(公告)日：1990-03-20

    申请号：US113967

    申请日：1987-10-29

    申请人： Atsuyuki Ashimori ,  Taizo Ono ,  Yoshihisa Inoue ,  Chikara Fukaya ,  Kazumasa Yokoyama

    发明人： Atsuyuki Ashimori ,  Taizo Ono ,  Yoshihisa Inoue ,  Chikara Fukaya ,  Kazumasa Yokoyama

    IPC分类号： C07D211/90 ,  A61K31/4427 ,  A61K31/455 ,  A61P3/00 ,  A61P7/02 ,  A61P9/12 ,  A61P43/00 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D417/12 ,  C07D417/14

    CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D417/12 ,  C07D417/14

    摘要： Dihydropyridine derivatives represented by formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.6, which may be the same or different, each represents an alkyl group, a cycloalkyl group or an alkoxyalkyl group; R.sub.4 and R.sub.5, which may be the same or different, each represents a hydrogen atom, a halogen atom, a nitro group, a halogenated alkyl group, an alkylsulfonyl group, a halogenated alkoxy group, an alkylsulfinyl group, an alkyl group, a cycloalkyl group, an alkxoy group, a cyano group, an alkoxycarbonyl group or an alkylthio group (provided that R.sub.4 and R.sub.5 are not hydrogen atoms at the same time); X represents a vinylene group or an azomethine group; A and B are each an alkylene group or an alkenylene group; R.sub.7 and R.sub.8, which may be the same or different, each represents a hydrogen atom, an alkyl group, an alkenyl group, an aralkyl group, an aryl group, or a heterocyclic group (provided that R.sub.7 and R.sub.8 may combine with the adjacent nitrogen atom to form a heterocyclic ring), and acid addition salts of the dihydropyridine derivatives of formula (I).

    摘要翻译： 由式（I）表示的二氢吡啶衍生物：其中R 1，R 2，R 3和R 6可以相同或不同，各自表示烷基，环烷基或烷氧基烷基; R 4和R 5可以相同或不同，各自表示氢原子，卤素原子，硝基，卤代烷基，烷基磺酰基，卤代烷氧基，烷基亚磺酰基，烷基，环烷基 基团，烷氧基，氰基，烷氧基羰基或烷硫基（条件是R4和R5不同时为氢原子）; X表示亚乙烯基或偶氮甲碱基; A和B各自为亚烷基或亚烯基; 可以相同或不同的R 7和R 8各自表示氢原子，烷基，烯基，芳烷基，芳基或杂环基（条件是R 7和R 8可以与相邻的氮 原子以形成杂环）和式（I）的二氢吡啶衍生物的酸加成盐。

    Dihydropyridine derivatives and pharmaceutical composition thereof
    7.
    发明授权
    Dihydropyridine derivatives and pharmaceutical composition thereof 失效
    二氢吡啶衍生物及其药物组合物

    公开(公告)号：US4886819A

    公开(公告)日：1989-12-12

    申请号：US87513

    申请日：1987-08-20

    申请人： Atsuyuki Ashimori ,  Taizo Ono ,  Yoshihisa Inoue ,  Chikara Fukaya ,  Kazumasa Yokoyama

    发明人： Atsuyuki Ashimori ,  Taizo Ono ,  Yoshihisa Inoue ,  Chikara Fukaya ,  Kazumasa Yokoyama

    IPC分类号： C07D211/90 ,  C07D401/04

    CPC分类号： C07D401/04 ,  C07D211/90

    摘要： Dihydropyridine derivatives of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, A, B are defined as in the specification and nontoxic acid-addition salts thereof, have an excellent calcium blocking action (Ca-antagonist), and antihypertensive action, a platelet aggregation-inhibiting action, a phosphodiesterase-inhibiting action and the like, and thus are useful as a medicine, such as a coronary vasocilator, a cerebral hyperkinemic, antihypertensive, thrombosis-preventing or -treating agents, phosphodiesterase-inhibitor or the like. Pharmaceutical compositions and methods of use are also disclosed.

    摘要翻译： 其中R 1，R 2，R 3，R 4，R 5，A，B如说明书中所定义的式（I）的二氢吡啶衍生物及其无毒酸加成盐具有优异的钙阻断作用（Ca-拮抗剂） ，抗高血压作用，血小板聚集抑制作用，磷酸二酯酶抑制作用等，因此可用作药物，例如冠状动脉血管扩张剂，脑hyperkinemic，抗高血压，预防或预防血栓形成剂，磷酸二酯酶 抑制剂等。 还公开了药物组合物和使用方法。