摘要:
To provide cytokine production inhibitors useful as preventive or therapeutic medicines for diseases accompanied by hyperactivated immune functions.A cytokine production inhibitor containing, as an active ingredient, a thioamide compound represented by the formula (I) or a salt thereof: wherein A is N, NO, C—NO2 or C—CN; Hal is a halogen; M1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, amino, O, S, SO or SO2; M2 is amino, O, S or a single bond; R1 is a halogen, alkyl or the like; each of R2, R3, R4 and R5 is independently H, alkyl or the like; R6 is a halogen, alkyl or the like; Cy is cycloalkyl, cycloalkenyl, aryl or heterocyclyl; each of k, p and q is independently an integer of from 0 to 3; and r is an integer of from 0 to 5.
摘要:
To provide cytokine production inhibitors useful as preventive or therapeutic medicines for diseases accompanied by hyperactivated immune functions. A cytokine production inhibitor containing, as an active ingredient, a thioamide compound represented by the formula (I) or a salt thereof: wherein A is N, NO, C—NO2 or C—CN; Hal is a halogen; M1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, amino, O, S, SO or SO2; M2 is amino, O, S or a single bond; R1 is a halogen, alkyl or the like; each of R2, R3, R4 and R5 is independently H, alkyl or the like; R6 is a halogen, alkyl or the like; Cy is cycloalkyl, cycloalkenyl, aryl or heterocyclyl; each of k, p and q is independently an integer of from 0 to 3; and r is an integer of from 0 to 5.
摘要翻译:提供可用作预防或治疗药物的细胞因子产生抑制剂,用于伴有过度活化的免疫功能的疾病。 含有式(I)所示的硫代酰胺化合物或其盐作为活性成分的细胞因子产生抑制剂:其中A为N,NO,C-NO 2或C-CN; 卤素是卤素; M 1是烷基,烯基,炔基,环烷基,环烯基,芳基,杂环基,氨基,O,S,SO或SO 2。 M 2是氨基,O,S或单键; R 1是卤素,烷基等; R 2,R 3,R 4和R 5各自独立地为H,烷基等; R 6是卤素,烷基等; Cy是环烷基,环烯基,芳基或杂环基; k,p和q各自独立地为0〜3的整数; r为0〜5的整数。
摘要:
Driving is effected by MLA under a condition of L≠M or (M/L·(L+D) )≠N where M represents the total number of row electrodes, L represents the number of simultaneously selected row electrodes, D represents the number of dummy row electrodes and N represents the maximum magnifying power of a column voltage wherein driving is performed at a driving bias ratio which is deviated toward the minimum bias ratio with respect to the optimum bias ratio.
摘要:
Presented is a driving device 301 for a liquid crystal panel 10, which is provided with a controller 1, a memory 2, a row selection pattern generating circuit 7, a row voltage generating circuit 9, a latch circuit 6B, a column voltage generating circuit 11 and an operating circuit 51 (a line buffer group 3, a comparator circuit 4, adder circuits 5A, 5B, a latch circuit 6A and an imaginary data generating circuit 8), wherein an orthogonal matrix B of 6 simultaneously selected rows and 2 imaginary rows which is formed by expanding an orthogonal matrix A of 4 rows is used for a row selection pattern, and column output voltages are operated with a unit of A.
摘要:
An anthracycline antibiotic FA-1180 A, A.sub.1, B or B.sub.1, or salts thereof, said antibiotic having the formula (I): ##STR1## wherein R represents an acetyl group or a 1-hydroxyethyl group.