公开(公告)号：US20070219215A1

公开(公告)日：2007-09-20

申请号：US10588859

申请日：2005-02-16

申请人： Fuminori Kato ,  Hirohiko Kimura ,  Kiyoshi Tamai ,  Kazuhiro Yamamoto ,  Mitsuo Sano ,  Shinya Mori ,  Takashi Okada ,  Toshihiko Ueki ,  Kumiko Azuma

发明人： Fuminori Kato ,  Hirohiko Kimura ,  Kiyoshi Tamai ,  Kazuhiro Yamamoto ,  Mitsuo Sano ,  Shinya Mori ,  Takashi Okada ,  Toshihiko Ueki ,  Kumiko Azuma

IPC分类号： A61K31/496 ,  A61K31/16 ,  A61K31/44 ,  C07D213/00 ,  C07D401/00 ,  C07C327/02 ,  A61K31/445

CPC分类号： C07D239/34 ,  C07C233/66 ,  C07C233/69 ,  C07C233/71 ,  C07C233/78 ,  C07C323/42 ,  C07C327/48 ,  C07C2603/74 ,  C07D213/83 ,  C07D239/42

摘要： To provide cytokine production inhibitors useful as preventive or therapeutic medicines for diseases accompanied by hyperactivated immune functions. A cytokine production inhibitor containing, as an active ingredient, a thioamide compound represented by the formula (I) or a salt thereof: wherein A is N, NO, C—NO2 or C—CN; Hal is a halogen; M1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, amino, O, S, SO or SO2; M2 is amino, O, S or a single bond; R1 is a halogen, alkyl or the like; each of R2, R3, R4 and R5 is independently H, alkyl or the like; R6 is a halogen, alkyl or the like; Cy is cycloalkyl, cycloalkenyl, aryl or heterocyclyl; each of k, p and q is independently an integer of from 0 to 3; and r is an integer of from 0 to 5.

摘要翻译： 提供可用作预防或治疗药物的细胞因子产生抑制剂，用于伴有过度活化的免疫功能的疾病。 含有式（I）所示的硫代酰胺化合物或其盐作为活性成分的细胞因子产生抑制剂：其中A为N，NO，C-NO 2或C-CN; 卤素是卤素; M 1是烷基，烯基，炔基，环烷基，环烯基，芳基，杂环基，氨基，O，S，SO或SO 2。 M 2是氨基，O，S或单键; R 1是卤素，烷基等; R 2，R 3，R 4和R 5各自独立地为H，烷基等; R 6是卤素，烷基等; Cy是环烷基，环烯基，芳基或杂环基; k，p和q各自独立地为0〜3的整数; r为0〜5的整数。

公开(公告)号：US07632865B2

公开(公告)日：2009-12-15

申请号：US10588859

申请日：2005-02-16

申请人： Fuminori Kato ,  Hirohiko Kimura ,  Kiyoshi Tamai ,  Kazuhiro Yamamoto ,  Mitsuo Sano ,  Shinya Mori ,  Takashi Okada ,  Toshihiko Ueki ,  Kumiko Azuma

发明人： Fuminori Kato ,  Hirohiko Kimura ,  Kiyoshi Tamai ,  Kazuhiro Yamamoto ,  Mitsuo Sano ,  Shinya Mori ,  Takashi Okada ,  Toshihiko Ueki ,  Kumiko Azuma

IPC分类号： A61K31/165 ,  C07C327/42

CPC分类号： C07D239/34 ,  C07C233/66 ,  C07C233/69 ,  C07C233/71 ,  C07C233/78 ,  C07C323/42 ,  C07C327/48 ,  C07C2603/74 ,  C07D213/83 ,  C07D239/42

摘要： To provide cytokine production inhibitors useful as preventive or therapeutic medicines for diseases accompanied by hyperactivated immune functions.A cytokine production inhibitor containing, as an active ingredient, a thioamide compound represented by the formula (I) or a salt thereof: wherein A is N, NO, C—NO2 or C—CN; Hal is a halogen; M1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, amino, O, S, SO or SO2; M2 is amino, O, S or a single bond; R1 is a halogen, alkyl or the like; each of R2, R3, R4 and R5 is independently H, alkyl or the like; R6 is a halogen, alkyl or the like; Cy is cycloalkyl, cycloalkenyl, aryl or heterocyclyl; each of k, p and q is independently an integer of from 0 to 3; and r is an integer of from 0 to 5.

摘要翻译： 提供可用作预防或治疗药物的细胞因子产生抑制剂，用于伴有过度活化的免疫功能的疾病。 1.一种细胞因子产生抑制剂，含有作为活性成分的式（I）所示的硫代酰胺化合物或其盐：其中A为N，NO，C-NO 2或C-CN; 卤素是卤素; M 1是烷基，烯基，炔基，环烷基，环烯基，芳基，杂环基，氨基，O，S，SO或SO 2; M2是氨基，O，S或单键; R1是卤素，烷基等; R2，R3，R4和R5各自独立地为H，烷基等; R6是卤素，烷基等; Cy是环烷基，环烯基，芳基或杂环基; k，p和q各自独立地为0〜3的整数; r为0〜5的整数。

公开(公告)号：US20130171226A1

公开(公告)日：2013-07-04

申请号：US13808218

申请日：2011-07-05

申请人： Takao Awazu ,  Mitsuo Sano ,  Akira Nakagawa

发明人： Takao Awazu ,  Mitsuo Sano ,  Akira Nakagawa

IPC分类号： A01N25/30

CPC分类号： A01N25/30 ,  A01N25/04 ,  A01N43/40 ,  A01N43/88 ,  A01N43/90 ,  A01N47/18 ,  A01N51/00 ,  A01N57/16

摘要： There has been a problem such that if a water-based pesticidal suspension containing, as an active ingredient, an agricultural chemical having a high aqueous solubility, particularly an agricultural chemical having an aqueous solubility exceeding 500 mg/L at 20° C., is stored for a long period of time, the active ingredient particles tend to grow and become coarse, whereby a stabilized suspension is hardly obtainable. To solve such a problem, the present invention provides a water-based pesticidal suspension comprising (a) an agricultural chemical or its salt having an aqueous solubility of from 500 mg/L to 6,000 mg/L at 20° C., (b) a polycarboxylate type surfactant, (c) a sulfonate type surfactant, and (d) water.

摘要翻译： 存在如下问题：如果含有水溶性较高的农药的水性杀虫剂悬浮液，特别是在20℃下水溶解度超过500mg / L的农药，则为 长时间储存​​时，活性成分颗粒易于生长并变得粗糙，难以获得稳定的悬浮液。 为了解决这个问题，本发明提供一种水性杀虫剂悬浮液，其包含（a）在20℃下水溶解度为500mg / L至6,000mg / L的农药或其盐，（b） 聚羧酸盐型表面活性剂，（c）磺酸盐型表面活性剂和（d）水。

公开(公告)号：US07037347B2

公开(公告)日：2006-05-02

申请号：US10333054

申请日：2001-07-12

申请人： Akio Kuzuhara ,  Mitsuo Sano

发明人： Akio Kuzuhara ,  Mitsuo Sano

IPC分类号： D06P1/39

CPC分类号： A61Q5/065 ,  A61K8/81 ,  A61K8/817 ,  A61K8/84 ,  A61K8/88 ,  A61K2800/5426

摘要： Pretreatment agents for hair colorings with acid dye comprising at least one cationic polymer selected from the group consisting of polymers having amino groups and polymers having quaternary ammonium groups. The pretreatment agents for hair colorings with acid dye are used for improving coloring ability and color fastness of hair colorings with acid dye.

摘要翻译： 包含至少一种选自具有氨基的聚合物和具有季铵基团的聚合物的至少一种阳离子聚合物的酸性染料的预处理剂。 用酸性染料染发的预处理剂用于提高染发剂的着色能力和染色牢度。

公开(公告)号：US09629360B2

公开(公告)日：2017-04-25

申请号：US13808218

申请日：2011-07-05

申请人： Takao Awazu ,  Mitsuo Sano ,  Akira Nakagawa

发明人： Takao Awazu ,  Mitsuo Sano ,  Akira Nakagawa

IPC分类号： A01N25/30 ,  A01N25/04 ,  A01N43/40 ,  A01P7/04 ,  A01P3/00

CPC分类号： A01N25/30 ,  A01N25/04 ,  A01N43/40 ,  A01N43/88 ,  A01N43/90 ,  A01N47/18 ,  A01N51/00 ,  A01N57/16

摘要： A water-based pesticidal suspension comprises (a) flonicamid, (b) a polycarboxylate surfactant, (c) a sulfonate surfactant, and (d) water. The sulfonate surfactant (c) is at least one member selected from the group consisting of an alkyl sulfosuccinate, a lignosulfonate, a C8-18 alkyl benzene sulfonate and a C8-18 alkyl diphenyl ether disulfonate. An average particle size of the volume distribution of (a) flonicamid is preferably from 0.5 μm to 10 μm. The polycarboxylate surfactant (b) is preferably a sodium salt of maleic acid/olefin copolymer.