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公开(公告)号：US20110129478A1
公开(公告)日：2011-06-02
申请号：US13002636
申请日：2009-07-10
申请人： Fumiyoshi Okano , Takanori Saito , Takayoshi Ido , Masaki Shimizu
发明人： Fumiyoshi Okano , Takanori Saito , Takayoshi Ido , Masaki Shimizu
IPC分类号： A61K39/395 , C07K16/18 , C07K2/00 , C12N15/13 , A61P35/00
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/3015 , C07K16/3061 , C07K2317/732 , C07K2317/734
摘要： An antibody or a fragment thereof having immunoreactivity to a polypeptide comprising not less than 7 continuous amino acids in the CD179b protein, which was identified as a cancer antigen protein specifically expressed on the surfaces of cancer cells, can be used as a pharmaceutical composition for therapy and/or prophylaxis of cancer.
摘要翻译： 可以将被鉴定为在癌细胞表面特异表达的癌抗原蛋白质的CD179b蛋白质中包含不少于7个连续氨基酸的多肽具有免疫反应性的抗体或其片段作为治疗用药物组合物 和/或预防癌症。
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2.发明授权Pharmaceutical composition for treating cancer using a monoclonal antibody having immunological reactivity with CAPRIN-1 有权使用具有与CAPRIN-1具有免疫反应性的单克隆抗体治疗癌症的药物组合物公开(公告)号：US09115200B2
公开(公告)日：2015-08-25
申请号：US13576969
申请日：2011-02-04
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , C07K16/30 , A61K39/00
CPC分类号： C07K16/3053 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K2317/34
摘要： According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody or a fragment thereof as an active ingredient having immunological reactivity to a partial polypeptide of CAPRIN-1, which is represented by any of even-numbered sequences of SEQ ID NOS: 2 to 30, wherein the polypeptide has the amino acid sequence represented by SEQ ID NO: 37 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence.
摘要翻译： 根据本发明，鉴定在癌细胞表面特异性表达的癌抗原蛋白，因此提供了靶向癌抗原蛋白的抗体作为治疗和/或预防癌症的药剂的用途。 具体地说，本发明提供了一种用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为对CAPRIN-1的部分多肽具有免疫反应性的活性成分， SEQ ID NO：2至30的编号序列，其中所述多肽具有由SEQ ID NO：37表示的氨基酸序列或与氨基酸序列具有80％或更高序列同一性的氨基酸序列。
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公开(公告)号：US20120301476A1
公开(公告)日：2012-11-29
申请号：US13576969
申请日：2011-02-04
IPC分类号： A61K39/395 , A61P35/00 , C07K16/30
CPC分类号： C07K16/3053 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K2317/34
摘要： According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody or a fragment thereof as an active ingredient having immunological reactivity to a partial polypeptide of CAPRIN-1, which is represented by any of even-numbered sequences of SEQ ID NOS: 2 to 30, wherein the polypeptide has the amino acid sequence represented by SEQ ID NO: 37 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence.
摘要翻译： 根据本发明，鉴定在癌细胞表面特异性表达的癌抗原蛋白，因此提供了靶向癌抗原蛋白的抗体作为治疗和/或预防癌症的药剂的用途。 具体地说，本发明提供了一种用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为对CAPRIN-1的部分多肽具有免疫反应性的活性成分， SEQ ID NO：2至30的编号序列，其中所述多肽具有由SEQ ID NO：37表示的氨基酸序列或与氨基酸序列具有80％或更高序列同一性的氨基酸序列。
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公开(公告)号：US20110256144A1
公开(公告)日：2011-10-20
申请号：US13057709
申请日：2009-08-05
IPC分类号： A61K39/395 , A61P35/00 , A61P35/02 , C07K16/18
CPC分类号： C07K16/3015 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K16/3053 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732 , C07K2317/734
摘要： The present invention relates to a pharmaceutical composition for treatment and/or prevention of cancer, which comprises, as an active ingredient, an antibody or fragment thereof having an immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising 7 or more consecutive amino acids.
摘要翻译： 本发明涉及用于治疗和/或预防癌症的药物组合物，其包含与包含7个或更多个连续氨基酸的CAPRIN-1蛋白或其片段具有免疫学反应性的抗体或其片段作为活性成分 酸。
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公开(公告)号：US09416192B2
公开(公告)日：2016-08-16
申请号：US13057709
申请日：2009-08-05
IPC分类号： A61K39/395 , C07K16/30
CPC分类号： C07K16/3015 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K16/3053 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732 , C07K2317/734
摘要： The present invention relates to a pharmaceutical composition for treatment and/or prevention of cancer, which comprises, as an active ingredient, an antibody or fragment thereof having an immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising 7 or more consecutive amino acids.
摘要翻译： 本发明涉及用于治疗和/或预防癌症的药物组合物，其包含与包含7个或更多个连续氨基的CAPRIN-1蛋白或其片段具有免疫学反应性的抗体或其片段作为活性成分 酸。
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公开(公告)号：US20120294860A1
公开(公告)日：2012-11-22
申请号：US13576950
申请日：2011-02-04
申请人： Takayoshi Ido , Fumiyoshi Okano , Yoshinori Narita
发明人： Takayoshi Ido , Fumiyoshi Okano , Yoshinori Narita
IPC分类号： A61K39/395 , A61P35/02 , A61P35/00
CPC分类号： A61K39/39558 , A61K2300/00
摘要： This invention relates to a medicament for treating and/or preventing a cancer, comprising a combination of an antibody against a cancer antigen CAPRIN-1 protein that is specifically expressed on the surface of the cancer cell, and an antitumor agent, wherein the antibody and the antitumor agent are combined together or separately, and to a use of the medicament.
摘要翻译： 本发明涉及用于治疗和/或预防癌症的药物，其包含抗癌细胞表面上特异性表达的癌抗原CAPRIN-1蛋白的抗体与抗肿瘤剂的组合，其中抗体和 将抗肿瘤药物组合在一起或分开，以及药物的用途。
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公开(公告)号：US09796775B2
公开(公告)日：2017-10-24
申请号：US14236807
申请日：2012-08-03
申请人： Takayoshi Ido , Fumiyoshi Okano
发明人： Takayoshi Ido , Fumiyoshi Okano
IPC分类号： A61K39/395 , A61K47/48 , A61K39/00 , A61K35/39 , C07K16/18 , C07K14/47 , G01N33/574 , C07K16/30 , C12Q1/68
CPC分类号： C07K16/18 , C07K14/47 , C07K14/4738 , C07K16/30 , C07K16/303 , C07K2317/34 , C07K2317/56 , C12Q1/6886 , C12Q2600/158 , G01N33/57438 , G01N2333/705
摘要： This invention relates to a method for detecting pancreatic cancer using novel tumor markers. Specifically, the invention provides a method for detecting pancreatic cancer comprising measuring the presence or an amount of a polypeptide having an reactivity of binding via an antigen-antibody reaction to an antibody against CAPRIN-1 protein in a sample separated from a subject, and to a reagent or kit for detecting pancreatic cancer comprising a CAPRIN-1 protein or a fragment thereof, an antibody against the same, or a polynucleotide encoding the same.
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公开(公告)号：US09180187B2
公开(公告)日：2015-11-10
申请号：US13576950
申请日：2011-02-04
申请人： Takayoshi Ido , Fumiyoshi Okano , Yoshinori Narita
发明人： Takayoshi Ido , Fumiyoshi Okano , Yoshinori Narita
IPC分类号： A61K39/395
CPC分类号： A61K39/39558 , A61K2300/00
摘要： This invention relates to a medicament for treating and/or preventing a cancer, comprising a combination of an antibody against a cancer antigen CAPRIN-1 protein that is specifically expressed on the surface of the cancer cell, and an antitumor agent, wherein the antibody and the antitumor agent are combined together or separately, and to a use of the medicament.
摘要翻译： 本发明涉及用于治疗和/或预防癌症的药物，其包含抗癌细胞表面上特异性表达的癌抗原CAPRIN-1蛋白的抗体与抗肿瘤剂的组合，其中抗体和 将抗肿瘤药物组合在一起或分开，以及药物的用途。
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公开(公告)号：US20140179558A1
公开(公告)日：2014-06-26
申请号：US14236807
申请日：2012-08-03
申请人： Takayoshi Ido , Fumiyoshi Okano
发明人： Takayoshi Ido , Fumiyoshi Okano
IPC分类号： G01N33/574 , C07K16/18 , C12Q1/68 , C07K14/47
CPC分类号： C07K16/18 , C07K14/47 , C07K14/4738 , C07K16/30 , C07K16/303 , C07K2317/34 , C07K2317/56 , C12Q1/6886 , C12Q2600/158 , G01N33/57438 , G01N2333/705
摘要： This invention relates to a method for detecting pancreatic cancer using novel tumor markers. Specifically, the invention provides a method for detecting pancreatic cancer comprising measuring the presence or an amount of a polypeptide having an reactivity of binding via an antigen-antibody reaction to an antibody against CAPRIN-1 protein in a sample separated from a subject, and to a reagent or kit for detecting pancreatic cancer comprising a CAPRIN-1 protein or a fragment thereof, an antibody against the same, or a polynucleotide encoding the same.
摘要翻译： 本发明涉及使用新型肿瘤标志物检测胰腺癌的方法。 具体地，本发明提供了一种检测胰腺癌的方法，包括测量在与受试者分离的样品中具有通过抗原 - 抗体反应与抗CAPRIN-1蛋白的抗体的结合反应性的多肽的存在或量，以及 用于检测胰腺癌的试剂或试剂盒，其包含CAPRIN-1蛋白质或其片段，针对其的抗体或编码该蛋白质的多核苷酸。
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