公开(公告)号：US20040043927A1

公开(公告)日：2004-03-04

申请号：US10081056

申请日：2002-02-20

Applicant: GENENTECH, INC.

Inventor： Kevin P. Baker ,  Napoleone Ferrara ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Scot A. Marsters ,  James Pan ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Weilan Ye

IPC: A61K038/17 ,  C07H021/04 ,  C12N009/00 ,  C12P021/02 ,  C12N005/06 ,  C07K014/435

CPC classification number: C07K14/515 ,  A61K38/00 ,  C07K2319/00 ,  G01N2800/32

Abstract: Compositions and methods are disclosed for stimulating or inhibiting angiogeniesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Abstract translation: 公开了用于刺激或抑制包括人在内的哺乳动物的血管生成和/或心血管化的组合物和方法。 药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。 可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如创伤，各种癌症和血管障碍，包括动脉粥样硬化和心脏肥大。 此外，本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US20030186866A1

公开(公告)日：2003-10-02

申请号：US10223081

申请日：2002-08-16

Applicant: Genentech, Inc.

Inventor： Kevin P. Baker ,  Napoleone Ferrara ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Scot A. Marsters ,  James Pan ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Weilan Ye

IPC: A61K038/17 ,  C12P021/02 ,  C12N005/06 ,  C07K014/47 ,  C07H021/04 ,  C12N009/00

CPC classification number: A61K38/17 ,  C07H21/04 ,  C07K14/435 ,  C07K14/47 ,  C12N5/06 ,  C12N9/00 ,  C12P21/02 ,  Y02A50/473

Abstract: Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20030125521A1

公开(公告)日：2003-07-03

申请号：US10223089

申请日：2002-08-16

Applicant: Genentech, Inc.

Inventor： Kevin P. Baker ,  Napoleone Ferrara ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Scot A. Marsters ,  James Pan ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Weilan Ye

IPC: C12P021/02 ,  C12N005/06 ,  C07K014/435 ,  A61K038/17 ,  C07H021/04 ,  C12N009/00

CPC classification number: A61K38/17 ,  C07H21/04 ,  C07K14/435 ,  C07K14/47 ,  C12N5/06 ,  C12N9/00 ,  C12P21/02

Abstract: Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20030224984A1

公开(公告)日：2003-12-04

申请号：US10305654

申请日：2002-11-26

Applicant: Genentech, Inc.

Inventor： Kevin P. Baker ,  Napoleone Ferrara ,  Hans-Peter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Scot A. Marsters ,  James Pan ,  Nicholas F. Paoni ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Weilan Ye

IPC: A61K038/17 ,  C07K014/47 ,  C07K016/18 ,  C12P021/02 ,  C12N005/06 ,  C07H021/04 ,  C12N009/00

CPC classification number: C07K16/22 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/515

Abstract: Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20030105013A1

公开(公告)日：2003-06-05

申请号：US10223090

申请日：2002-08-16

Applicant: Genentech, Inc.

Inventor： Kevin P. Baker ,  Napoleone Ferrara ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Scot A. Marsters ,  James Pan ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Weilan Ye

IPC: A61K038/17 ,  C12P021/02 ,  C12N005/06 ,  C07K014/435 ,  C07H021/04 ,  C12N009/00

CPC classification number: A61K38/17 ,  C07H21/04 ,  C07K14/435 ,  C07K14/47 ,  C12N5/06 ,  C12N9/00 ,  C12P21/02

Abstract: Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20020150993A1

公开(公告)日：2002-10-17

申请号：US10116378

申请日：2002-04-04

Applicant: Genentech, Inc.

Inventor： Avi J. Ashkenazi ,  Audrey Goddard ,  Austin Gurney ,  Scot A. Marsters ,  Robert M. Pitti ,  William I. Wood

IPC: A61K038/17 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06 ,  C07K014/715

CPC classification number: C07K14/70578 ,  A61K38/00 ,  C07K14/4747 ,  C07K14/70575 ,  C07K2319/00 ,  C12N2799/026

Abstract: The present invention is directed to novel polypeptides having homology to members of the tumor necrosis factor receptor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Abstract translation: 本发明涉及与肿瘤坏死因子受体家族的成员具有同源性的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US20040234498A1

公开(公告)日：2004-11-25

申请号：US10713391

申请日：2003-11-14

Applicant: Genentech, Inc.

Inventor： Avi J. Ashkenazi ,  Kevin P. Baker ,  Paul J. Godowski ,  Austin L. Gurney ,  Melanie R. Mark ,  Scot A. Marsters ,  Robert M. Pitti

IPC: A61K038/19 ,  C07H021/04 ,  C12P021/02 ,  C07K014/525

CPC classification number: C07K14/525 ,  A61K38/00 ,  C07K2319/02

Abstract: A tumor necrosis factor homolog, identified as DNA19355, is provided. DNA19355 polypeptide has apoptotic activity in mammalian cancer cells and may be involved in proinflammatory responses. Nucleic acid molecules encoding DNA19355, chimeric molecules and antibodies to DNA19355 are also provided.

Abstract translation: 提供了鉴定为DNA19355的肿瘤坏死因子同源物。 DNA19355多肽在哺乳动物癌细胞中具有凋亡活性，并且可能参与促炎反应。 还提供了编码DNA19355的核酸分子，嵌合分子和DNA19355的抗体。

公开(公告)号：US20030211096A1

公开(公告)日：2003-11-13

申请号：US10211858

申请日：2002-08-02

Applicant: Genentech, Inc.

Inventor： Avi J. Ashkenazi ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Scot A. Marsters ,  James Pan ,  Robert M. Pitti ,  Margaret Ann Roy ,  Victoria Smith ,  Donna M. Stone ,  Colin K. Watanabe ,  William I. Wood

IPC: A61K039/395 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06 ,  C07K016/40

CPC classification number: C07K16/30

Abstract: The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Abstract translation: 本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。 本发明基于在肿瘤细胞基因组中扩增的基因的鉴定。 预期这种基因扩增与相同组织类型的正常细胞相比，与基因产物的过表达有关，并且有助于肿瘤发生。 因此，由扩增的基因编码的蛋白质被认为是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US20030119112A1

公开(公告)日：2003-06-26

申请号：US10223083

申请日：2002-08-16

Applicant: Genentech, Inc.

Inventor： Kevin P. Baker ,  Napoleone Ferrara ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Scot A. Marsters ,  James Pan ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Weilan Ye

IPC: C12P021/02 ,  C12N005/06 ,  C07K014/435 ,  C07H021/04 ,  C12N009/00

CPC classification number: A61K38/17 ,  C07H21/04 ,  C07K14/435 ,  C07K14/47 ,  C12N5/06 ,  C12N9/00 ,  C12P21/02

Abstract: Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20030109438A1

公开(公告)日：2003-06-12

申请号：US10223087

申请日：2002-08-16

Applicant: Genentech, Inc.

Inventor： Kevin P. Baker ,  Napoleone Ferrara ,  Hanspeter Gerber ,  Mary E. Gerritsen ,  Audrey Goddard ,  Paul J. Godowski ,  Austin L. Gurney ,  Kenneth J. Hillan ,  Scot A. Marsters ,  James Pan ,  Jean-Philippe F. Stephan ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood ,  Weilan Ye

IPC: A61K038/17 ,  C07H021/04 ,  C12N009/00 ,  C12P021/02 ,  C12N005/06 ,  C07K014/435

CPC classification number: A61K38/17 ,  C07H21/04 ,  C07K14/435 ,  C07K14/47 ,  C12N5/06 ,  C12N9/00 ,  C12P21/02

Abstract: Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Abstract translation: 公开了用于刺激或抑制哺乳动物，包括人类的血管发生和/或心血管化的组合物和方法。 药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。 可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如创伤，各种癌症和血管障碍，包括动脉粥样硬化和心脏肥大。 此外，本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。