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公开(公告)号：US11273310B2
公开(公告)日：2022-03-15
申请号：US16253430
申请日：2019-01-22
Applicant: General Electric Company , Albany Medical College
Inventor： Radhika Madhavan , Jeffrey Ashe , Suresh Joel , Ileana Hancu , Julie Pilitsis , Marisa DiMarzio
Abstract: A system and method for optimizing parameters of a DBS pulse signal for treatment of a patient is provided. In predicting optimal DBS parameters, functional brain data is input into a predictor system, the functional brain data acquired responsive to a sweeping across a multi-dimensional parameter space of one or more DBS parameters. Statistical metrics of brain response are extracted from the functional brain data for one or more ROIs or voxels of the brain via the predictor system, and a DBS functional atlas is accessed, via the predictor system, that comprises disease-specific brain response maps derived from DBS treatment at optimal DBS parameter settings for a plurality of diseases or neurological conditions. One or more optimal DBS parameters are predicted for the patient based on the statistical metrics of brain response and the DBS functional atlas via the predictor system.
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公开(公告)号：US20180199895A1
公开(公告)日：2018-07-19
申请号：US15406895
申请日：2017-01-16
Applicant: General Electric Company
Inventor： Eric William Fiveland , Ileana Hancu , Jeffrey Ashe
IPC: A61B5/00 , A61B5/04 , A61B5/055 , A61N1/36 , A61B5/0408
CPC classification number: A61B5/7285 , A61B5/0042 , A61B5/04004 , A61B5/04017 , A61B5/0408 , A61B5/0476 , A61B5/0478 , A61B5/0482 , A61B5/055 , A61B5/7203 , A61B5/7257 , A61B5/7435 , A61B6/037 , A61N1/0534 , A61N1/3605 , A61N1/3606 , G01R33/4806
Abstract: A system and method for analyzing bioelectrical signals generated during a deep brain stimulation (DBS) includes an apparatus having a housing having a signal input and a signal output and an electrical circuit disposed within the housing and electrically coupled between the signal input and the signal output. The electrical circuit is configured to receive bioelectrical signals corresponding to a cyclic excitation signal transmitted by a pulse generator during a DBS and generate an output signal comprising a series of timing pulses, wherein each timing pulse simulates an envelope of the cyclic excitation signal. The signal output of the housing is electrically coupleable to an auxiliary trigger input of an imaging system and the series of timing pulses can be used to trigger image data acquisition.
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公开(公告)号：US11039855B2
公开(公告)日：2021-06-22
申请号：US16002486
申请日：2018-06-07
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Robert David Darrow , Ileana Hancu , Eric William Fiveland
Abstract: A guide insert for use in insertion of a medical tool into a patient and an associated method of using the guide insert in a medical device are disclosed. The guide insert includes a base sized and shaped to be inserted into an opening of a grid of the medical device, a rotatable structure configured to fit on or within the base, and a securing cap configured to secure the rotatable structure to the base and to prevent rotation of the rotatable structure when secured.
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公开(公告)号：US20200230414A1
公开(公告)日：2020-07-23
申请号：US16253430
申请日：2019-01-22
Applicant: General Electric Company , Albany Medical College
Inventor： Radhika Madhavan , Jeffrey Ashe , Suresh Joel , Ileana Hancu , Julie Pilitsis , Marisa DiMarzio
Abstract: A system and method for optimizing parameters of a DBS pulse signal for treatment of a patient is provided. In predicting optimal DBS parameters, functional brain data is input into a predictor system, the functional brain data acquired responsive to a sweeping across a multi-dimensional parameter space of one or more DBS parameters. Statistical metrics of brain response are extracted from the functional brain data for one or more ROIs or voxels of the brain via the predictor system, and a DBS functional atlas is accessed, via the predictor system, that comprises disease-specific brain response maps derived from DBS treatment at optimal DBS parameter settings for a plurality of diseases or neurological conditions. One or more optimal DBS parameters are predicted for the patient based on the statistical metrics of brain response and the DBS functional atlas via the predictor system.
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5.发明申请公开(公告)号：US20190255315A1
公开(公告)日：2019-08-22
申请号：US15899594
申请日：2018-02-20
Applicant: General Electric Company
Inventor： Sathish Ramani , Rolf Schulte , Ileana Hancu , Jeffrey Ashe , Graeme C. McKinnon
Abstract: A system and method for localizing a deep brain stimulation electrode in vivo in a subject or object is provided. A magnetic resonance imaging system obtains MR image data from a volume-of-interest by way of a zero echo time (ZTE) or ultrashort echo time (UTE) pulse sequence, with one or more of a phase domain image and a magnitude domain image being analyzed from the MR image data acquired by the ZTE or UTE pulse sequence. One or more electrodes are localized within the volume-of-interest based on an analysis of the phase domain image and/or magnitude domain image. In localizing the electrodes, a multi-scale correlation-based analysis of the volume-of-interest is performed to estimate at least one of an electrode center and electrode contact locations of the electrode, with the localization being achieved with a fast scan-time and with a high level of accuracy and precision.
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Patent Agency Ranking
公开(公告)号：US09974521B2
公开(公告)日：2018-05-22
申请号：US14618316
申请日：2015-02-10
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Ileana Hancu , Robert David Darrow , Eric William Fiveland , Xiaofeng Liu
CPC classification number: A61B10/0233 , A61B5/0555 , A61B5/4312 , A61B5/742 , A61B2576/02
Abstract: The system and method of the invention pertains to an MR-guided breast biopsy procedure, specifically as to quickly identifying the biopsy location. More particularly, the system utilizes a diagnostic imaging modality such as magnetic resonance imaging (MRI) to locate one or more lesions in a human breast. Non-rigid registration between uncompressed screening images (where the lesion has been previously identified) and the compressed biopsy images enables easier identification of the biopsy site, hence shortening the biopsy procedure.
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公开(公告)号：US20160278746A1
公开(公告)日：2016-09-29
申请号：US14671252
申请日：2015-03-27
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Ileana Hancu , Robert David Darrow , Eric William Fiveland , Mauricio Castillo-Effen , Seung-Kyun Lee
CPC classification number: A61B10/0266 , A61B5/004 , A61B5/055 , A61B5/06 , A61B5/4312 , A61B34/20 , A61B90/11 , A61B2034/2048 , A61B2505/05 , G01R33/4808
Abstract: The system and method of the invention pertains to an MR-guided breast biopsy procedure, specifically as to real-time tracking and navigation of a biopsy device. More particularly, the system utilizes a diagnostic imaging modality such as magnetic resonance imaging (MRI) to locate lesions in a human breast while utilizing an inertial measurement unit (IMU) to track advancement of a biopsy device in real-time. The invention simplifies the workflow of MRI-guided breast biopsies, shortens the time needed to perform the biopsy, decreases cost, and increases accuracy. This is achieved by enabling real-time visualization of the biopsy device as it advances towards the targeted lesion.
Abstract translation: 本发明的系统和方法涉及MR指导的乳腺活检程序，具体涉及活检装置的实时跟踪和导航。 更具体地，系统利用诸如磁共振成像（MRI）的诊断成像模式来定位人乳房中的病变，同时利用惯性测量单元（IMU）来实时跟踪活检装置的进展。 本发明简化了MRI指导乳腺活组织检查的工作流程，缩短了进行活组织检查所需的时间，降低了成本，提高了准确性。 这是通过使活检装置在朝向目标病变的方向上实时可视化来实现的。
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8.发明授权公开(公告)号：US09645214B2
公开(公告)日：2017-05-09
申请号：US14095707
申请日：2013-12-03
Applicant: General Electric Company
Inventor： Ileana Hancu , Selaka Bandara Bulumulla , Florian Wiesinger , Laura Irene Sacolick , Seung Kyun Lee
CPC classification number: G01R33/4816 , G01R33/246
Abstract: Systems and methods for determining electrical properties using Magnetic Resonance Imaging (MRI) are provided. One method includes applying an ultra-short echo time (TE) pulse sequence in a Magnetic Resonance Imaging (MRI) system and acquiring a complex B1+B1− quantity from an object following the application of the ultra-short TE pulse sequence, where B1+ is a complex amplitude of a transmit radio-frequency (RF) magnetic field and B1− is a complex amplitude of a receive RF magnetic field. The method also includes estimating, with a processor, one or more electrical properties of the object using the complex amplitudes of the transmit RF magnetic field and the receive RF magnetic field.
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公开(公告)号：US09149205B2
公开(公告)日：2015-10-06
申请号：US13852723
申请日：2013-03-28
Applicant: General Electric Company
Inventor： Ileana Hancu , Kenneth William Rohling , Luca Marinelli , Eric William Fiveland , Seung-Kyun Lee , Keith J. Park
CPC classification number: A61B5/0555 , A61B5/708
Abstract: The present disclosure relates to a receive coil assembly for use in magnetic resonance imaging of breast tissue. In certain embodiments the assembly comprises separable parts: a configurable mechanical support and a flexible receive coil array. The adjustability and separability of the receive coil array relative to the mechanical support allows the receive coil array to substantially conform to the breasts of the patient during imaging.
Abstract translation: 本公开涉及一种用于乳腺组织的磁共振成像的接收线圈组件。 在某些实施例中，组件包括可分离部件：可配置的机械支撑件和柔性接收线圈阵列。 接收线圈阵列相对于机械支撑件的可调节性和可分离性允许接收线圈阵列在成像期间基本上符合患者的乳房。
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公开(公告)号：US20140296701A1
公开(公告)日：2014-10-02
申请号：US13852723
申请日：2013-03-28
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Ileana Hancu , Kenneth William Rohling , Luca Marinelli , Eric William Fiveland , Seung-Kyun Lee , Keith J. Park
CPC classification number: A61B5/0555 , A61B5/708
Abstract: The present disclosure relates to a receive coil assembly for use in magnetic resonance imaging of breast tissue. In certain embodiments the assembly comprises separable parts: a configurable mechanical support and a flexible receive coil array. The adjustability and separability of the receive coil array relative to the mechanical support allows the receive coil array to substantially conform to the breasts of the patient during imaging.
Abstract translation: 本公开涉及一种用于乳腺组织的磁共振成像的接收线圈组件。 在某些实施例中，组件包括可分离部件：可配置的机械支撑件和柔性接收线圈阵列。 接收线圈阵列相对于机械支撑件的可调节性和可分离性允许接收线圈阵列在成像期间基本上符合患者的乳房。
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