公开(公告)号：US10076249B2

公开(公告)日：2018-09-18

申请号：US14817450

申请日：2015-08-04

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Silke Maria Lechner-Greite ,  Florian Wiesinger ,  Desmond Teck Beng Yeo ,  Matthew Richard Tarasek

IPC: A61B5/00 ,  A61B5/01 ,  G01R33/48 ,  G01R33/56 ,  A61B18/18 ,  A61B18/00 ,  A61B18/02 ,  A61B18/04

CPC classification number: A61B5/015 ,  A61B5/055 ,  A61B5/4836 ,  A61B5/7214 ,  A61B5/7285 ,  A61B18/02 ,  A61B18/04 ,  A61B18/1815 ,  A61B2018/00577 ,  A61B2018/00791 ,  G01R33/4804 ,  G01R33/4814 ,  G01R33/4816 ,  G01R33/5602

Abstract: A system and method for tracking temperature changes in tissue and bone is disclosed. In one aspect, the temperature changes are tracked simultaneously with high spatial encoding and temporal efficiency. The method is robust in terms of B0 and chemical shift off-resonance, as well as insensitive to eddy currents for accurate temperature mapping. Zero TE (ZTE) based MR thermometry is utilized herein to extract temperature changes from proton density and T1 weighted images. Additionally, T1 signal contamination is corrected for by calibrating T1 and B0 by using a variable flip angle method to achieve temperature mapping in bone, aqueous and adipose tissue simultaneously.

公开(公告)号：US20160174868A1

公开(公告)日：2016-06-23

申请号：US14577770

申请日：2014-12-19

Applicant: GENERAL ELECTRIC COMPANY ,  MEMORIAL SLOAN-KETTERING CANCER CENTER

Inventor： Matthew Richard Tarasek ,  Thomas Kwok-Fah Foo ,  Desmond Teck Beng Yeo ,  Oguz Akin

IPC: A61B5/055 ,  G01R33/48 ,  A61N1/00 ,  A61B5/01 ,  A61B18/08 ,  A61B18/02 ,  A61N7/02 ,  A61N5/00 ,  G01R33/31 ,  A61B5/00

CPC classification number: A61B5/055 ,  A61B5/0051 ,  A61B5/0053 ,  A61B5/01 ,  A61B5/4836 ,  A61B5/7278 ,  A61B5/7282 ,  A61F7/02 ,  A61F2007/0054 ,  A61F2007/0071 ,  A61F2007/0095 ,  A61F2007/0295 ,  A61N7/02 ,  G01R33/4804 ,  G01R33/50 ,  G01R33/5608 ,  G01R33/56341

Abstract: The present disclosure describes non-invasive approaches for delineating and characterizing tissue using MR imaging over a range of treatment levels. By way of example, tumor tissue may be distinguished and delineated from other tissue, such as muscle tissue. Further, tumor tissue may be characterized as malignant or benign using such approaches.

Abstract translation: 本公开描述了在一系列治疗水平上使用MR成像描绘和表征组织的非侵入性方法。 举例来说，可以区分肿瘤组织并从其它组织例如肌肉组织描绘。 此外，使用这种方法可以将肿瘤组织表征为恶性或良性。

公开(公告)号：US10405773B2

公开(公告)日：2019-09-10

申请号：US14577770

申请日：2014-12-19

Applicant: GENERAL ELECTRIC COMPANY ,  MEMORIAL SLOAN-KETTERING CANCER CENTER

Inventor： Matthew Richard Tarasek ,  Thomas Kwok-Fah Foo ,  Desmond Teck Beng Yeo ,  Oguz Akin

IPC: G01R33/48 ,  A61B5/055 ,  A61B5/00 ,  A61N7/02 ,  A61B5/01 ,  A61F7/02 ,  G01R33/50 ,  G01R33/56 ,  G01R33/563 ,  A61F7/00

Abstract: The present disclosure describes non-invasive approaches for delineating and characterizing tissue using MR imaging over a range of treatment levels. By way of example, tumor tissue may be distinguished and delineated from other tissue, such as muscle tissue. Further, tumor tissue may be characterized as malignant or benign using such approaches.

公开(公告)号：US20170035301A1

公开(公告)日：2017-02-09

申请号：US14817450

申请日：2015-08-04

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Silke Maria Lechner-Greite ,  Florian Wiesinger ,  Desmond Teck Beng Yeo ,  Matthew Richard Tarasek

IPC: A61B5/01 ,  G01R33/56 ,  A61B18/20 ,  A61B5/00 ,  A61B18/18 ,  G01R33/58 ,  G01R33/48

CPC classification number: A61B5/015 ,  A61B5/4836 ,  A61B5/7214 ,  A61B5/7285 ,  A61B18/02 ,  A61B18/04 ,  A61B18/1815 ,  A61B2018/00577 ,  A61B2018/00791 ,  G01R33/4804 ,  G01R33/4814 ,  G01R33/4816 ,  G01R33/5602

Abstract: A system and method for tracking temperature changes in tissue and bone is disclosed. In one aspect, the temperature changes are tracked simultaneously with high spatial encoding and temporal efficiency. The method is robust in terms of B0 and chemical shift off-resonance, as well as insensitive to eddy currents for accurate temperature mapping. Zero TE (ZTE) based MR thermometry is utilized herein to extract temperature changes from proton density and T1 weighted images. Additionally, T1 signal contamination is corrected for by calibrating T1 and B0 by using a variable flip angle method to achieve temperature mapping in bone, aqueous and adipose tissue simultaneously.

Abstract translation: 公开了用于跟踪组织和骨骼中的温度变化的系统和方法。 在一个方面，温度变化与高空间编码和时间效率同时跟踪。 该方法在B0和化学位移偏共振方面是稳健的，以及对于精确温度映射的涡流不敏感。 本文利用基于零TE（ZTE）的MR测温来提取质子密度和T1加权图像的温度变化。 此外，通过使用可变翻转角法来校准T1和B0来校正T1信号污染，以同时实现骨，水和脂肪组织中的温度映射。