公开(公告)号：US20190002968A1

公开(公告)日：2019-01-03

申请号：US15770922

申请日：2016-08-26

Applicant: Roche Molecular Systems, Inc. ,  Genia Technologies, Inc.

Inventor： Frank BERGMANN ,  Christoph SEIDEL ,  Andrew TRANS ,  Dmitriy GREMYACHINSKIY ,  Hannes KUCHELMEISTER ,  Lars HILLRINGHAUS

IPC: C12Q1/6869 ,  C07H19/10 ,  C07H19/20

Abstract: The present disclosure relates to compositions and methods based on polypeptide-tagged nucleotide, and the use of such polypeptide-tagged nucleotides in nanopore devices and methods.

公开(公告)号：US20190002509A1

公开(公告)日：2019-01-03

申请号：US16134179

申请日：2018-09-18

Applicant: GENIA TECHNOLOGIES, INC.

Inventor： Dmitriy GREMYACHINSKIY ,  Christos TZITZILONIS

IPC: C07K14/315 ,  C07K19/00 ,  C12N15/62 ,  C07K1/107 ,  C12N9/52 ,  C12N9/12 ,  A61K47/64

Abstract: The present disclosure relates to relates methods and associated compositions that provide fast, efficient site-selective conjugation of a protein, such as the pore-forming protein α-hemolysin, to a biomolecule, such as a DNA polymerase, and the use of such site-selective protein-biomolecule conjugates in nanopore devices and methods.