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公开(公告)号:US10772858B2
公开(公告)日:2020-09-15
申请号:US15570969
申请日:2016-05-02
IPC分类号: A61K31/192 , A61K31/495 , A01N31/04 , A61K31/7068 , A61K31/536 , A61K31/435 , A61K31/175 , A61K31/17 , A61K31/475 , A61K31/166 , A61P35/00 , A61K31/085 , A61K31/09 , A61K31/341 , A61K31/343 , A61K31/351 , A61K31/352 , A61K31/357 , A61K31/381 , A61K31/397 , A61K31/40 , A61K31/421 , A61K31/436 , A61K31/443 , A61K31/444 , A61K31/445 , A61K31/5375 , A61K31/538 , A61K45/06 , C07C43/295 , C07D205/04 , C07D207/12 , C07D211/46 , C07D213/65 , C07D263/32 , C07D265/36 , C07D295/096 , C07D307/12 , C07D307/20 , C07D307/79 , C07D309/10 , C07D311/70 , C07D319/16 , C07D333/54 , C07D405/12 , C07D491/052
摘要: This disclosure relates to benzhydrol derivatives for managing conditions related to the Hypoxia Inducible Factor (HIF) pathway such as uses in treating cancer. In certain embodiment, the disclosure contemplates compounds and pharmaceutical compositions. In certain embodiment, the disclosure contemplates compounds disclosed herein as prodrugs, optionally substituted with one or more substituents, derivatives, or salts thereof.