公开(公告)号：US11053250B2

公开(公告)日：2021-07-06

申请号：US16537385

申请日：2019-08-09

Applicant: Gilead Sciences, Inc.

Inventor： Stephen Ammann ,  Elizabeth M. Bacon ,  Gediminas Brizgys ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  Marilyn Ndukwe ,  James G. Taylor ,  Nathan E. Wright ,  Zheng-Yu Yang ,  Sheila M. Zipfel

IPC: C07D487/04 ,  A61K31/5025 ,  A61P29/00

Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.

公开(公告)号：US11046686B2

公开(公告)日：2021-06-29

申请号：US16539834

申请日：2019-08-13

Applicant: Gilead Sciences, Inc.

Inventor： Stephen Ammann ,  Elizabeth M. Bacon ,  Gediminas Brizgys ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  Marilyn Ndukwe ,  Marina Shatskikh ,  James G. Taylor ,  Nathan E. Wright ,  Zheng-Yu Yang ,  Sheila M. Zipfel

IPC: C07D471/04 ,  C07D487/04

Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.

公开(公告)号：US20160108030A1

公开(公告)日：2016-04-21

申请号：US14771779

申请日：2014-02-28

Applicant: Gilead Sciences, Inc.

Inventor： Gediminas Brizgys ,  Eda Canales ,  Chien-Hung Chou ,  Michael Graupe ,  Yunfeng Eric Hu ,  Scott E. Lazerwith ,  John O. Link ,  Qi Liu ,  Yafan Lu ,  Roland D. Saito ,  Scott D. Schroeder ,  John R. Somoza ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D471/04 ,  A61K45/06 ,  C07D401/14 ,  A61K31/517 ,  A61K31/4439 ,  C07D417/14 ,  A61K31/506 ,  A61K31/4709 ,  C07D413/14 ,  A61K31/496 ,  A61K31/5377 ,  C07D491/052 ,  A61K31/444 ,  C07D401/12

CPC classification number: C07D401/12 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052

Abstract: Compounds of formula (I) or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

Abstract translation: 公开了式（I）化合物或其盐。 还公开了包含式I化合物的药物组合物，制备式I化合物的方法，可用于制备式I化合物的中间体和用于治疗包括HIV病毒引起的感染的逆转录病毒科病毒感染的治疗方法。

公开(公告)号：US09050344B2

公开(公告)日：2015-06-09

申请号：US14151758

申请日：2014-01-09

Applicant: Gilead Sciences, Inc.

Inventor： Gediminas Brizgys ,  Chien-Hung Chou ,  Randall L. Halcomb ,  Yunfeng Eric Hu ,  Qi Liu ,  John R. Somoza ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: A61K31/5377 ,  C07D401/14 ,  C07D401/12 ,  C07D403/14 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K45/06 ,  C07D403/12 ,  C07D405/14 ,  C07D491/107

CPC classification number: A61K31/5377 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D491/107

Abstract: Compounds of formula I: or pharmaceutically acceptable salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

Abstract translation: 公开了式I化合物或其药学上可接受的盐。 还公开了包含式I化合物的药物组合物，制备式I化合物的方法，可用于制备式I化合物的中间体和用于治疗包括HIV病毒引起的感染的逆转录病毒科病毒感染的治疗方法。

公开(公告)号：US20220267302A1

公开(公告)日：2022-08-25

申请号：US17584643

申请日：2022-01-26

Applicant: Gilead Sciences, Inc.

Inventor： Gediminas Brizgys ,  Eda Canales ,  Chienhung Chou ,  Michael Graupe ,  Jiayao Li ,  Roland D. Saito ,  Scott D. Schroeder ,  Winston C. Tse ,  Qiaoyin Wu ,  Jennifer R. Zhang

IPC: C07D401/14 ,  A61P31/18 ,  C07D405/14 ,  C07D413/14

Abstract: The invention provides compounds having Formula (I): or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.

公开(公告)号：US20210214363A1

公开(公告)日：2021-07-15

申请号：US17110734

申请日：2020-12-03

Applicant: Gilead Sciences, Inc.

Inventor： Stephen Ammann ,  Elizabeth M. Bacon ,  Gediminas Brizgys ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  Marilyn Ndukwe ,  James G. Taylor ,  Nathan E. Wright ,  Zheng-Yu Yang ,  Sheila M. Zipfel

IPC: C07D487/04

Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof, wherein the variable substituents are disclosed herein.

公开(公告)号：US20210009555A1

公开(公告)日：2021-01-14

申请号：US16882804

申请日：2020-05-26

Applicant: Gilead Sciences, Inc.

Inventor： Gediminas Brizgys ,  Eda Canales ,  Chien-Hung Chou ,  Michael Graupe ,  Randall L. Halcomb ,  Yunfeng Eric Hu ,  Scott E. Lazerwith ,  John O. Link ,  Qi Liu ,  Yafan Lu ,  Roland D. Saito ,  Scott D. Schroeder ,  John R. Somoza ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D471/04 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K45/06 ,  C07D491/052 ,  C07D401/04 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04

Abstract: Compounds of formula (I) or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

公开(公告)号：US20200071333A1

公开(公告)日：2020-03-05

申请号：US16539753

申请日：2019-08-13

Applicant: Gilead Sciences, Inc.

Inventor： Stephen Ammann ,  Elizabeth M. Bacon ,  Gediminas Brizgys ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  Marilyn Ndukwe ,  James G. Taylor ,  Nathan E. Wright ,  Zheng-Yu Yang ,  Sheila M. Zipfel

IPC: C07D487/04

Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.

公开(公告)号：US09873680B2

公开(公告)日：2018-01-23

申请号：US14836774

申请日：2015-08-26

Applicant: Gilead Sciences, Inc.

Inventor： Gediminas Brizgys ,  Eda Canales ,  Randall L. Halcomb ,  Yunfeng Eric Hu ,  Darryl Kato ,  John O. Link ,  Qi Liu ,  Roland D. Saito ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D493/04 ,  C07D498/04 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D519/00

CPC classification number: C07D401/14 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  A61P31/18 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D493/04 ,  C07D498/04 ,  C07D519/00

Abstract: Compounds of formula I: or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

公开(公告)号：US20160083368A1

公开(公告)日：2016-03-24

申请号：US14836774

申请日：2015-08-26

Applicant: Gilead Sciences, Inc.

Inventor： Gediminas Brizgys ,  Eda Canales ,  Randall L. Halcomb ,  Yunfeng Eric Hu ,  Darryl Kato ,  John O. Link ,  Qi Liu ,  Rpland D. Saito ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D401/14 ,  A61K45/06 ,  A61K31/4439 ,  C07D471/04 ,  A61K31/444 ,  C07D493/04 ,  A61K31/4709 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/506 ,  C07D519/00

CPC classification number: C07D401/14 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  A61P31/18 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D493/04 ,  C07D498/04 ,  C07D519/00

Abstract: Compounds of formula I: or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

Abstract translation: 公开了式I化合物或其盐。 还公开了包含式I化合物的药物组合物，制备式I化合物的方法，可用于制备式I化合物的中间体和用于治疗包括HIV病毒引起的感染的逆转录病毒科病毒感染的治疗方法。