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公开(公告)号：US20230212150A1
公开(公告)日：2023-07-06
申请号：US18062363
申请日：2022-12-06
IPC分类号： C07D401/14 , C07D401/04 , C07D413/14
CPC分类号： C07D401/14 , C07D401/04 , C07D413/14
摘要： The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH), interstitial lung disease (ILD), or chronic kidney disease (CKD).
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公开(公告)号：US20230079863A1
公开(公告)日：2023-03-16
申请号：US17704440
申请日：2022-03-25
发明人： James L. Bachman , Daniel H. Byun , Christopher T. Clark , Petr Jansa , Joshua A. Kaplan , Zachary A. Kasun , Jennifer R. Lo , Megan E. Neubig , Nathaniel H. Stanley , Kirk L. Stevens
IPC分类号： C07D409/14 , C07D405/14 , C07D403/14 , C07D401/14 , C07D495/04 , C07D513/04 , C07D493/10 , C07D491/107 , C07D413/14 , C07D403/04 , A61K45/06
摘要： Compounds of formula: wherein the variable substituents are defined herein.
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公开(公告)号：US20160096827A1
公开(公告)日：2016-04-07
申请号：US14863108
申请日：2015-09-23
发明人： Zhimin Du , Juan A. Guerrero , Joshua A. Kaplan , John E. Knox, JR. , Jennifer R. Lo , Scott A. Mitchell , Devan Naduthambi , Barton W. Phillips , Chandrasekar Venkataramani , Peiyuan Wang , William J. Watkins , Zhongdong Zhao
IPC分类号： C07D405/12 , C07D405/14 , A61K31/53 , C07D403/14 , C07D409/14 , A61K31/5383 , A61K31/5377 , C07D417/14 , C07D491/107 , C07D471/10 , C07D413/14 , C07D498/04 , A61K31/541 , C07D403/12
CPC分类号： C07D405/12 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/107 , C07D491/113 , C07D498/04
摘要： Compounds having the following formula (I) and methods of their use and preparation are disclosed:
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公开(公告)号：US11980609B2
公开(公告)日：2024-05-14
申请号：US17741222
申请日：2022-05-10
IPC分类号： A61K31/4155 , C07D231/40 , C07D401/04 , C07D401/14 , C07D403/04
CPC分类号： A61K31/4155 , C07D231/40 , C07D401/04 , C07D401/14 , C07D403/04
摘要： The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH), interstitial lung disease (TLD), or chronic kidney disease (CKD).
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公开(公告)号：US20230212151A1
公开(公告)日：2023-07-06
申请号：US18062469
申请日：2022-12-06
发明人： Brian P. Bestvater , Zhimin Du , Julie Farand , Joshua A. Kaplan , Barton W. Phillips , Doris T. Tang , Chandrasekar Venkataramani , Peiyuan Wang , Kin S. Yang , Anna Zagorska
IPC分类号： C07D401/14 , C07D413/14
CPC分类号： C07D401/14 , C07D413/14
摘要： The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH), interstitial lung disease (ILD), or chronic kidney disease (CKD).
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公开(公告)号：US10040781B2
公开(公告)日：2018-08-07
申请号：US14863108
申请日：2015-09-23
发明人： Zhimin Du , Juan A. Guerrero , Joshua A. Kaplan , John E. Knox, Jr. , Jennifer R. Lo , Scott A. Mitchell , Devan Naduthambi , Barton W. Phillips , Chandrasekar Venkataramani , Peiyuan Wang , William J. Watkins , Zhongdong Zhao
IPC分类号： C07D405/12 , C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D409/14 , C07D417/14 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D498/04 , C07D403/14 , C07D491/107 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541
摘要： Compounds having the following formula (I) and methods of their use and preparation are disclosed:
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公开(公告)号：US20230270719A1
公开(公告)日：2023-08-31
申请号：US18059806
申请日：2022-11-29
发明人： Jinfa Du , Joshua A. Kaplan , Thorsten A. Kirschberg , Tetsuya Kobayashi , Scott E. Lazerwith , Rick Andrew Lee , Jonathan William Medley , Michael L. Mitchell , Philip Anthony Morganelli , Hyung-Jung Pyun , Sophia L. Shevick , Neil H. Squires , William J. Watkins
IPC分类号： A61K31/403 , C07D487/04 , C07D519/00 , A61P31/20 , A61K31/03 , A61K31/16 , A61K31/38 , A61K31/4192
CPC分类号： A61K31/403 , C07D487/04 , C07D519/00 , A61P31/20 , A61K31/03 , A61K31/16 , A61K31/38 , A61K31/4192
摘要： This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.
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公开(公告)号：US11584738B2
公开(公告)日：2023-02-21
申请号：US17319507
申请日：2021-05-13
发明人： Brian P. Bestvater , Zhimin Du , Julie Farand , Joshua A. Kaplan , Barton W. Phillips , Doris T. Tang , Chandrasekar Venkataramani , Peiyuan Wang , Kin S. Yang , Anna Zagorska
IPC分类号： C07D401/14 , C07D409/14 , C07D405/14
摘要： The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH), interstitial lung disease (ILD), or chronic kidney disease (CKD).
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公开(公告)号：US20220411405A1
公开(公告)日：2022-12-29
申请号：US17741222
申请日：2022-05-10
IPC分类号： C07D401/14 , C07D231/40 , C07D401/04 , C07D403/04
摘要： The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH), interstitial lung disease (TLD), or chronic kidney disease (CKD).
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公开(公告)号：US20200255418A1
公开(公告)日：2020-08-13
申请号：US16741101
申请日：2020-01-13
发明人： Peter A. Blomgren , Kevin S. Currie , Morin Mae Frick , Elizabeth M. Horstman , Joshua A. Kaplan , Jeffrey E. Kropf , William J. Watkins
IPC分类号： C07D413/14
摘要： The present disclosure relates generally to compounds that bind to FXR and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.
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