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公开(公告)号：US20240182476A1
公开(公告)日：2024-06-06
申请号：US18450646
申请日：2023-08-16
发明人： Masaaki Sawa , Mai Arai , Ryoko Nakai , Hirokazu Matsumoto , Catherine Pugh , Eric Hu , Juan Guerrero , Jesse Jacobsen , Jonathan William Medley , Jie Xu , Latesh Lad , Leena Patel , Michael Graupe , Qingming Zhu , Stephen Holmbo , Tetsuya Kobayashi , Will Watkins , Yasamin Moazami , Suet C. Yeung , Julian A. Codelli , Heath A. Weaver
IPC分类号： C07D487/04 , A61K31/395 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/55 , A61K31/553 , A61K31/695 , A61K31/704 , A61K31/7068 , A61K35/15 , A61K35/17 , A61K39/395 , A61K45/06 , C07D519/00 , C07F7/18
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/55 , A61K31/553 , A61K31/5545 , A61K31/695 , A61K31/704 , A61K31/7068 , A61K35/15 , A61K35/17 , A61K39/3955 , A61K45/06 , C07D519/00 , C07F7/1804
摘要： The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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公开(公告)号：US12054490B2
公开(公告)日：2024-08-06
申请号：US18450646
申请日：2023-08-16
发明人： Masaaki Sawa , Mai Arai , Ryoko Nakai , Hirokazu Matsumoto , Jonathan William Medley , Leena Patel , Qingming Zhu , Tetsuya Kobayashi
IPC分类号： C07D487/04 , A61K31/395 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/55 , A61K31/553 , A61K31/695 , A61K31/704 , A61K31/7068 , A61K35/15 , A61K35/17 , A61K39/395 , A61K45/06 , C07D519/00 , C07F7/18
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/55 , A61K31/553 , A61K31/5545 , A61K31/695 , A61K31/704 , A61K31/7068 , A61K35/15 , A61K35/17 , A61K39/3955 , A61K45/06 , C07D519/00 , C07F7/1804
摘要： The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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公开(公告)号：US11845723B2
公开(公告)日：2023-12-19
申请号：US17127297
申请日：2020-12-18
发明人： Masaaki Sawa , Mai Arai , Ryoko Nakai , Hirokazu Matsumoto , Catherine Pugh , Eric Hu , Juan Guerrero , Jesse Jacobsen , Jonathan William Medley , Jie Xu , Latesh Lad , Leena Patel , Michael Graupe , Qingming Zhu , Stephen Holmbo , Tetsuya Kobayashi , Will Watkins , Yasamin Moazami , Suet C. Yeung , Julian A. Codelli , Heath A. Weaver
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/55 , A61K31/553 , A61K31/704 , A61K31/7068 , C07D519/00 , A61K31/554 , A61K31/695 , A61K31/395 , A61K35/15 , A61K35/17 , A61K39/395 , A61K45/06 , C07F7/18
CPC分类号： C07D487/04 , A61K31/519 , A61K31/538 , A61K31/5377 , A61K31/55 , A61K31/553 , A61K31/5545 , A61K31/695 , A61K31/704 , A61K31/7068 , A61K35/15 , A61K35/17 , A61K39/3955 , A61K45/06 , C07D519/00 , C07F7/1804
摘要： The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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公开(公告)号：US20230348494A1
公开(公告)日：2023-11-02
申请号：US18181116
申请日：2023-03-09
发明人： Hang Chu , Juan A. Guerrero , Anna E. Hurtley , Lan Jiang , Darryl Kato , Tetsuya Kobayashi , David W. Lin , Jonathan William Medley , Devan Naduthambi , Vickie H. Tsui , Chandrasekar Venkataramani , William J. Watkins , Hong Yang , Qingming Zhu
IPC分类号： C07D513/18 , A61K45/06 , C07D513/08 , C07D513/20 , C07D513/22 , C07D519/00 , C07K16/28
CPC分类号： C07D513/18 , A61K45/06 , C07D513/08 , C07D513/20 , C07D513/22 , C07D519/00 , C07K16/2818 , C07K16/2827
摘要： The present disclosure generally relates to compounds of Formula (I) and pharmaceutical compositions that may be used in methods of treating cancer.
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