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公开(公告)号：US11896632B2
公开(公告)日：2024-02-13
申请号：US17573049
申请日：2022-01-11
发明人： Hsieh-Hsun Ho , Yi-Wei Kuo , Ching-Wei Chen , Wen-Yang Lin , Jui-Fen Chen , Shu-Hui Chen
CPC分类号： A61K35/747 , A61K8/99 , A61P31/04 , C12N1/205 , A61Q11/00 , C12R2001/225
摘要： Disclosed herein are methods for inhibiting growth of oral pathogenic bacteria and alleviating an oral pathogenic bacteria-associated disorder using a culture of at least one lactic acid bacterial strain selected from the group consisting of Lactobacillus rhamnosus MP108 which is deposited at the China General Microbiological Culture Collection Center (CGMCC) under an accession number CGMCC 21225, and Lactobacillus paracasei MP137 which is deposited at the CGMCC under an accession number CGMCC 21224.
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公开(公告)号：US20220273735A1
公开(公告)日：2022-09-01
申请号：US17511689
申请日：2021-10-27
发明人： Hsieh-Hsun Ho , Wen-Yang Lin , Yi-Wei Kuo , Yen-Yu Huang , Jia-Hung Lin , Chi-Huei Lin , Cheng-Ruei Liu , Shu-Hui Chen
IPC分类号： A61K35/747 , A61P31/04 , C12N1/20
摘要： The invention provides a method of increasing an amount of oral immunoglobulin A (IgA) and/or inhibiting oral pathogens in a subject in need thereof, which utilizes a composition including a therapeutically effective amount of probiotics as an effective ingredient. The probiotics include Lactobacillus plantarum LPL28, which can efficiently increase the amount of oral IgA and/or inhibit the oral pathogens, and thus have a potential to prevent teeth cavities and/or periodontal diseases.
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公开(公告)号：US12005091B2
公开(公告)日：2024-06-11
申请号：US17726843
申请日：2022-04-22
发明人： Hsieh-Hsun Ho , Wen-Yang Lin , Jui-Fen Chen , Yi-Wei Kuo , Jia-Hung Lin , Chi-Huei Lin , Ching-Wei Chen , Yu-Fen Huang
IPC分类号： A61K35/747 , A61P31/04
CPC分类号： A61K35/747 , A61P31/04
摘要： The present invention discloses a method for maintaining or improving gastrointestinal condition, which includes: administering a lactic acid bacterial composition to a subject in need thereof, wherein the lactic acid bacterial composition comprises: a Lactobacillus paracasei ET-66 strain with a deposition number CGMCC 13514. The present invention also discloses a method for maintaining or improving gastrointestinal condition, which includes: administering a lactic acid bacterial fermentation composition to a subject in need thereof, wherein the lactic acid bacterial fermentation composition comprises: a fermentation product of a Lactobacillus paracasei ET-66 strain.
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公开(公告)号：US11957722B2
公开(公告)日：2024-04-16
申请号：US17688024
申请日：2022-03-07
发明人： Hsieh-Hsun Ho , Yi-Wei Kuo , Wen-Yang Lin , Jia-Hung Lin , Yen-Yu Huang , Chi-Huei Lin , Shin-Yu Tsai
IPC分类号： A61K35/747 , A23L33/135 , A61K8/99 , A61Q19/08 , C12N1/20 , C12R1/225
CPC分类号： A61K35/747 , A23L33/135 , A61K8/99 , A61Q19/08 , C12N1/205 , C12R2001/225
摘要： The present invention discloses an anti-aging composition, which includes: (a) isolated lactic acid bacterial strains or a fermented product thereof; and (b) an excipient, a diluent, or a carrier; wherein the isolated lactic acid bacterial strains include: Bifidobacterium bifidum VDD088 strains, Bifidobacterium breve Bv-889 strains, and Bifidobacterium longum BLI-02 strains. The present invention further provides a method for preventing aging by administering the foregoing anti-aging composition to a subject in need thereof.
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公开(公告)号：US11911421B2
公开(公告)日：2024-02-27
申请号：US17455466
申请日：2021-11-18
发明人： Hsieh-Hsun Ho , Wen-Yang Lin , Yi-Wei Kuo , Yen-Yu Huang , Jia-Hung Lin
IPC分类号： A61K35/745 , A61K35/747 , A61P3/10 , C12N1/20 , C12R1/225
CPC分类号： A61K35/745 , A61K35/747 , A61P3/10 , C12N1/205 , C12R2001/225
摘要： Disclosed herein is a probiotic composition that includes Lactobacillus salivarius subsp. salicinius AP-32, Lactobacillus johnsonii MH-68, and Bifidobacterium animalis subsp. lactis CP-9, which are deposited at the China Center for Type Culture Collection (CCTCC) respectively under accession numbers CCTCC M 2011127, CCTCC M 2011128, and CCTCC M 2014588. A number ratio of Lactobacillus salivarius subsp. salicinius AP-32, Lactobacillus johnsonii MH-68, and Bifidobacterium animalis subsp. lactis CP-9 ranges from 1:0.1:0.1 to 1:1:8. Also disclosed herein is use of the probiotic composition for alleviating type 1 diabetes mellitus (T1DM).
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6.发明授权公开(公告)号：US11779615B2
公开(公告)日：2023-10-10
申请号：US17378955
申请日：2021-07-19
发明人： Chi-Chang Huang , Mon-Chien Lee , Yi-Ju Hsu , Hsieh-Hsun Ho , Yi-Wei Kuo , Wen-Yang Lin , Jia-Hung Lin , Chi-Huei Lin
IPC分类号： A61K35/747 , A61P3/04 , C12N1/20 , A23L33/135 , A61K35/745
CPC分类号： A61K35/747 , A23L33/135 , A61K35/745 , A61P3/04 , C12N1/205
摘要： The present invention provides a lactic acid bacteria composition, which comprises: a Lactobacillus plantarum PL-02 strain, a Lactobacillus acidophilusTYCA06 strain, a Lactobacillus casei CS-773 strain, and a physiologically acceptable excipient, diluent, or carrier. All of the strains are deposited at the China General Microbiological Culture Collection Center.
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公开(公告)号：US20230173000A1
公开(公告)日：2023-06-08
申请号：US17688024
申请日：2022-03-07
发明人： Hsieh-Hsun Ho , Yi-Wei Kuo , Wen-Yang Lin , Jia-Hung Lin , Yen-Yu Huang , Chi-Huei Lin , Shin-Yu Tsai
IPC分类号： A61K35/747 , A61K8/99 , A23L33/135 , C12N1/20 , A61Q19/08
CPC分类号： A61K35/747 , A61K8/99 , A23L33/135 , C12N1/205 , A61Q19/08 , C12R2001/225
摘要： The present invention discloses an anti-aging composition, which includes: (a) isolated lactic acid bacterial strains or a fermented product thereof; and (b) an excipient, a diluent, or a carrier; wherein the isolated lactic acid bacterial strains include: Bifidobacterium bifidum VDD088 strains, Bifidobacterium breve Bv-889 strains, and Bifidobacterium longum BLI-02 strains. The present invention further provides a method for preventing aging by administering the foregoing anti-aging composition to a subject in need thereof.
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公开(公告)号：US12005090B2
公开(公告)日：2024-06-11
申请号：US17449699
申请日：2021-10-01
发明人： Hsieh-Hsun Ho , Ching-Wei Chen , Yu-Fen Huang , Yi-Wei Kuo , Wen-Yang Lin , Yen-Yu Huang
IPC分类号： A61K35/747 , A23L33/135 , A61K35/745 , A61P3/04
CPC分类号： A61K35/747 , A23L33/135 , A61K35/745 , A61P3/04
摘要： Disclosed herein is a probiotic composition including Lactobacillus salivarius subsp. salicinius AP-32 that is deposited at the China Center for Type Culture Collection (CCTCC) under an accession number CCTCC M 2011127, and Bifidobacterium longum subsp. longum OLP-01 that is deposited at the China General Microbiological Culture Collection Center (CGMCC) under an accession number CGMCC 17345. Also disclosed herein are use of at least one of the abovementioned lactic acid bacterial strains for treating obesity and/or an obesity-related disorder, and for inhibiting fat absorption.
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公开(公告)号：US11913047B2
公开(公告)日：2024-02-27
申请号：US17647436
申请日：2022-01-07
发明人： Hsieh-Hsun Ho , Ching-Wei Chen , Yu-Fen Huang , Chen-Hung Hsu , Wen-Yang Lin , Yi-Wei Kuo , Shin-Yu Tsai
CPC分类号： C12P13/001 , A23L33/135 , C12N1/205 , C12P39/00 , A23V2002/00 , A23V2400/113 , A23V2400/169 , A23V2400/181 , A23V2400/519 , A23V2400/529 , C12R2001/23 , C12R2001/25
摘要： A method for producing γ-aminobutyric acid includes cultivating, in a culture medium containing glutamic acid or a salt thereof, a probiotic composition including at least one lactic acid bacterial strain selected from the group consisting of Bifidobacterium breve CCFM1025 which is deposited at the Guangdong Microbial Culture Collection Center under an accession number GDMCC 60386, Lactobacillus acidophilus TYCA06, Lactobacillus plantarum LPL28, and Bifidobacterium longum subsp. infantis BLI-02 which are deposited at the China General Microbiological Culture Collection Center respectively under accession numbers CGMCC 15210, CGMCC 17954, and CGMCC 15212, Lactobacillus salivarius subsp. salicinius AP-32 which is deposited at the China Center for Type Culture Collection under an accession number CCTCC M 2011127, and combinations thereof.
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公开(公告)号：US11759487B2
公开(公告)日：2023-09-19
申请号：US17511689
申请日：2021-10-27
发明人： Hsieh-Hsun Ho , Wen-Yang Lin , Yi-Wei Kuo , Yen-Yu Huang , Jia-Hung Lin , Chi-Huei Lin , Cheng-Ruei Liu , Shu-Hui Chen
IPC分类号： A01N63/00 , A61K35/747 , C12N1/20 , A61P31/04 , C12R1/25
CPC分类号： A61K35/747 , A61P31/04 , C12N1/20 , C12R2001/25
摘要： The invention provides a method of increasing an amount of oral immunoglobulin A (IgA) and/or inhibiting oral pathogens in a subject in need thereof, which utilizes a composition including a therapeutically effective amount of probiotics as an effective ingredient. The probiotics include Lactobacillus plantarum LPL28, which can efficiently increase the amount of oral IgA and/or inhibit the oral pathogens, and thus have a potential to prevent teeth cavities and/or periodontal diseases.
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