公开(公告)号：US20160051658A1

公开(公告)日：2016-02-25

申请号：US14750837

申请日：2015-06-25

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Cesira GALEOTTI ,  Guido GRANDI ,  Vega MASIGNANI ,  Marirosa MORA ,  Mariagrazia PIZZA ,  Rino RAPPUOLI ,  Giulio RATTI ,  Vincenzo SCARLATO ,  Maria SCARSELLI

IPC: A61K39/095

CPC classification number: A61K39/095 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/55505 ,  C07K14/22

Abstract: This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto e.g., antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, and/or fragments, as well as host cells transformed with such vectors. This invention also provides compositions of the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments, and/or nucleic acids.

Abstract translation: 本发明尤其提供衍生自脑膜炎奈瑟氏球菌B细菌的蛋白质，多肽和其片段。还提供编码这种蛋白质，多肽和/或片段的核酸，以及与其互补的核酸，例如， 反义核酸）。 另外，本发明提供了结合蛋白质，多肽和/或片段的抗体。 本发明进一步提供了可用于制备蛋白质，多肽和/或片段以及用这些载体转化的宿主细胞的表达载体。 本发明还提供用作疫苗，诊断试剂，免疫原性组合物等的蛋白质，多肽，片段和/或核酸的组合物。 还提供了用组合物制备组合物和处理方法的方法。 本发明还提供了检测蛋白质，多肽，片段和/或核酸的方法。

公开(公告)号：US20170080077A1

公开(公告)日：2017-03-23

申请号：US15368435

申请日：2016-12-02

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Maria ARICÒ ,  Maurizio COMANDUCCI ,  Cesira GALEOTTI ,  Vega MASIGNANI ,  Marzia Monica GIULIANI ,  Mariagrazia PIZZA

IPC: A61K39/095

CPC classification number: A61K39/095 ,  A61K38/00 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/572 ,  A61K2039/575 ,  C07K14/22 ,  C07K2319/00 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/689 ,  C12Q2600/156

Abstract: Alternative and improved approaches to the heterologous expression of the proteins of Neisseria meningitidis and Neisseria gonorrhoeae are disclosed. These approaches typically affect the level of expression, the ease of purification, the cellular localization, and/or the immunological properties of the expressed protein.

公开(公告)号：US20170080076A1

公开(公告)日：2017-03-23

申请号：US15368429

申请日：2016-12-02

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Maria ARICÒ ,  Maurizio COMANDUCCI ,  Cesira GALEOTTI ,  Vega MASIGNANI ,  Marzia Monica GIULIANI ,  Mariagrazia PIZZA

IPC: A61K39/095

CPC classification number: A61K39/095 ,  A61K38/00 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/572 ,  A61K2039/575 ,  C07K14/22 ,  C07K2319/00 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/689 ,  C12Q2600/156

Abstract: Alternative and improved approaches to the heterologous expression of the proteins of Neisseria meningitidis and Neisseria gonorrhoeae are disclosed. These approaches typically affect the level of expression, the ease of purification, the cellular localization, and/or the immunological properties of the expressed protein.

公开(公告)号：US20160030545A1

公开(公告)日：2016-02-04

申请号：US14804756

申请日：2015-07-21

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Claire FRASER ,  Cesira GALEOTTI ,  Guido GRANDI ,  Erin HICKEY ,  Vega MASIGNANI ,  Marirosa MORA ,  Jeremy PETERSEN ,  Mariagrazia PIZZA ,  Rino RAPPUOLI ,  Giulio RATTI ,  Vincenzo SCARLATO ,  Maria SCARSELLI ,  Herve TETTELIN ,  J. Craig VENTER

IPC: A61K39/095 ,  C07K14/22

CPC classification number: C07K14/22 ,  A61K38/00 ,  A61K39/00 ,  A61K39/095 ,  A61K2039/55505 ,  Y10S530/806 ,  Y10S530/825

Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.